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Pharmaceutical Drugs
 
Red Wine may reduce the absorption of Cyclosporine (causing Cyclosporine treatment to be less effective). Therefore Red Wine should not be consumed by persons receiving Cyclosporine treatment.
 
Red Wine Compared to White Wine
 
The color of Wine is not related to the color of the Grapes used in its manufacture – the color of Wine is actually governed by the method of manufacture.
 
Red Wine White Wine*
Type of Grape: Red Grapes or White Grapes
 
Part of Grape Used: Whole Grape (including Skin, Seeds and part of the String) Juice of the Grape only
Production Method: Whole Grapes are crushed and left together for two to three weeks, during which the pigments (Anthocyanins) and OPCs (from the Skin and Seeds) gradually dissolve into the Wine during the process known as maceration. After extraction of juice, the seeds and skins are discarded and the juice is fermented to eventually produce wine.
Nutrient Differences: Finished product contains a large amount of Anthocyanins and OPCs. Finished product contains approximately 3% of the quantity of OPCs and Tannins as Red Wine. Methanol: 200 ppm Methanol (the compound that may be responsible for Hangovers). 50 ppm Methanol.
 
Some Eastern European countries produce macerated White Wine which is manufactured by a similar process to Red Wine using White Grapes, resulting in a White Wine that includes a much greater quantity of OPC than unmacerated White Wine.
 
 
Optimal Consumption of Wine
 
Studies that have demonstrated health benefits for Red Wine indicate that the protective level of Red Wine consumption occurs at approximately two glasses per day (250 ml per day). Consumption of Red Wine in excess of two glasses pay day may initiate the negative effects of excessive Alcohol (ethanol).
 
Commercial Availability of Supplemental Wine Extracts
 
Red Wine extracts are available from health food and nutrition outlets in the form of:
 
– 300 mg capsules.
– 500 mg capsules
 
Supplemental Red Wine extracts are usually labeled as Red Wine Polyphenols and are often standardized to contain 20% – 100% Polyphenols (including up to 35% Anthocyanosides).
 
Description
 
Resveratrol is a type of Phytoalexin (a class of Polyphenol compounds produced as a part of a plant’s defense system against disease). Resveratrol is produced (in the plants in which it is present) during times of environmental stress, such as adverse weather, insect attack, animal attack or pathogenic attack. It is both water-soluble and fat-soluble.
 
 
Health Benefits of Resveratrol
 
Aging Process
 
Resveratrol may retard the progression of the Aging Process.
 
Resveratrol may possess Life Extension properties (due to its ability to increase the activity of Sir2p).
 
Cardiovascular System
 
Resveratrol may help to prevent Arrhythmias.
 
Resveratrol may prevent Atherosclerosis.
 
Resveratrol may inhibit abnormal Blood Clotting.
 
Resveratrol may help to protect the Heart from the toxic effects of Free Radicals (due to the Antioxidant effects of Resveratrol):
 
Resveratrol may help to protect the Heart from (cardiac) Fibrosis.
 
Resveratrol may reduce the toxic effects of Ischemia/Reperfusion injury in the Brain after (ischemic) Stroke.
 
Digestive System
 
Resveratrol may alleviate (acute) Pancreatitis.
 
Ears/Hearing
 
Resveratrol may help to prevent Noise-Induced Hearing Loss.
 
Excretory System
 
Resveratrol may help to prevent Diabetic Nephropathy.
 
 
 
 
Immune System
 
Resveratrol may help to prevent various forms of Cancer.
 
Resveratrol may prevent Cancer via several mechanisms: it may act as an antimutagen; it may stimulates phase II drug-metabolizing enzymes (i.e. it may possess anti-initiation activity)it may induce cell differentiation in Cancer cells (i.e. it possesses anti-progression activity).
 
Resveratrol may help to prevent Breast Cancer. One of the means by which Resveratrol may help to prevent Breast Cancer is by functioning as a Phytoestrogen – specifically it appears to beneficially interfere with the activity of Estradiol. It binds to Receptors that would otherwise bind to Estradiol and thereby prevents Estradiol from relaying Cancer cell promotion “messages”.
 
Resveratrol may inhibit the further progression of Colon Cancer.
 
Resveratrol may stimulate the apoptosis (cell death) of Esophageal Cancer cells. references
– Resveratrol may stimulate the apoptosis (programmed cell death) of the Cells involved in Gliomas
 
õResveratrol may help to prevent Kidney Cancer and may retard the further progression of Kidney Cancer.
 
õResveratrol may inhibit the further progression of (the Acute Promyelocytic form of) Leukemia and may stimulate the apoptosis (cell death) of Acute Promyelocytic Leukemia cells.

Resveratrol may help to prevent and treat Liver Cancer (due to its ability to stimulate the apoptosis (cell death) of Liver Cancer cells. references
 
õResveratrol may help to “shrink” the tumors involved in Lung Cancer, may stimulate the Apoptosis (cellular death) of Lung Cancer cells and may inhibit the metastasis of Lung Cancer. references
 
õResveratrol may stimulate the apoptosis (cell death) of Multiple Myeloma cells.
 
õResveratrol may be useful for the treatment of Neuroblastoma.
õResveratrol may stimulate the apoptosis (cell death) of Ovarian Cancer cells.
 
õResveratrol may help to prevent and treat Pancreatic Cancer (due to its ability to stimulate the apoptosis (cell death) of Pancreatic Cancer cells. references
 
õResveratrol may inhibit the growth of Prostate Cancer cells.
 
õResveratrol may inhibit the proliferation of Rhabdomyosarcoma cells.
 
õResveratrol may help to prevent Skin Cancer:
 
õResveratrol may inhibit the growth of Melanoma.
 
õResveratrol may stimulate the apoptosis (death) of Thyroid Cancer cells.

Part of Resveratrol’s anti-Cancer effect may be derived from its ability to inhibit Nuclear Factor-
Kappa B (NF-Kappa B).
 
Resveratrol may inhibit some types of Detrimental Fungi:
 
õResveratrol may inhibit/kill Candida albicans.
 
õResveratrol may inhibit the replication of Herpes Simplex Viruses:
 
õResveratrol may inhibit the replication of the Herpes Simplex Virus Type 1.
 
õResveratrol may inhibit the replication of the Herpes Simplex Virus Type 2.
 
õResveratrol may suppress Inflammation. references
 
õResveratrol may inhibit the replication of Influenza Viruses (and may therefore help to prevent Influenza
 
Metabolism
 
Resveratrol possesses Antioxidant properties:
 
Resveratrol scavenges Peroxyl Free Radicals.
 
Resveratrol may lower total serum Cholesterol levels:
 
Resveratrol may increase HDL Cholesterol levels.
 
Resveratrol may prevent the oxidation of LDL Cholesterol.
 
Resveratrol may facilitate weight loss in persons afflicted with Obesity (due to Resveratrol increasing the activity of Sir2p).
 
Nervous System
 
õResveratrol may be useful for the prevention/treatment of Alzheimer’s Disease (by inhibiting the neurotoxic effects of Amyloid-Beta Protein in the Brain).
 
Respiratory System
 
Resveratrol may help to prevent/treat Chronic Obstructory Pulmonary Disease (COPD) (by inhibiting the increased production of Interleukin 8 that occurs during COPD).
 
Resveratrol may Enhance the Function of these Substances
 
 
 
 
Enzymes
 
õResveratrol may increase Quinone Reductase levels (this is one of the means by which Resveratrol may exert anti-cancer effects).
 
Resveratrol may increase the activity of Sir2p.
 
Glycosides
 
Resveratrol is a component of Polydatin: Polydatin is the Glycoside of Resveratrol.
 
Lipids
 
Resveratrol may enhance the ability of Butyric Acid to prevent Colon Cancer. references
 
Second Messengers
 
Resveratrol elevates Cyclic AMP (cAMP) levels.
 
Resveratrol may Inhibit these Potentially Toxic Substances
 
Amines
 
Resveratrol may reduce the toxicity (carcinogenicity) of Nitrosamines.
 
Electromagnetic Radiation
 
Resveratrol may inhibit the ability of UV-B to damage the Skin.
 
Environmental Toxins
 
Resveratrol may inhibit the conversion of Polynuclear Aromatic Hydrocarbons (PAHs) to carcinogens.
 
Enzymes
 
Resveratrol may inhibit Cyclooxygenase-2 (COX-2) catalyzed Thromboxane synthesis. references
 
Resveratrol may inhibit Ornithine Decarboxylase.
 
Immune System Chemicals
 
Resverarol may inhibit the release of Interleukin 8 in respiratory system epithelial cells.
 
Lipids
 
Resveratrol may inhibit the production of Thromboxane A2.
 
Neurotoxins
 
Resveratrol may inhibit the neurotoxic effects of Kainic Acid.
 
Proteins
 
Resveratrol may inhibit Activator Protein-1. [more info]
 
Resveratrol may inhibit the neurotoxic effects of Amyloid-Beta Protein in the Brain.
 
Resveratrol may inhibit the production of Nuclear Factor-Kappa B (NF-Kappa B).
 
õResveratrol may reduce intracellular and secreted levels of Prostate-Specific Antigen (PSA).
 
Dietary Sources of Resveratrol
 
(mg of Resveratrol per 100 grams)
 
 
Alcoholic Beverages: Red Wine *
Fruits: Grapes **7.5 Raisins Mulberry Cranberry Blueberry Bilberry
Herbs: Hu Zhang Yucca Japanese Knotweed ***
Nuts: Peanuts 0.25
 
The Resveratrol content of Red Wine is approximately 0.1 – 15.0 mg per liter – pinot noir grapes appear to have the highest content of all Red Wines while very few White Wines contain any Resveratrol. The Resveratrol content of Wine is related to the length of time the Grape skins are present during the fermentation process. Therefore the concentration is significantly higher in Red Wine than in White Wine because the skins are removed earlier during White Wine production, thereby reducing the amount that is extracted. references
 
** Resveratrol is present in Grape skins, seeds, stalks, vines and roots (but not the flesh of the fruit). The highest concentration of Resveratrol is found in Grape skins. Grape juice contains very little resveratrol compared to Red Wine. The resveratrol content of Grape Skins is 50 – 100 mcg per gram (5,000 – 10,000 mcg per 100 grams [5 – 10 mg per 100 grams]). references
 
*** Japanese Knotweed is claimed to be the highest known source of Resveratrol (containing 1,000 times the Resveratrol content of Grapes).
 
Bioavailability
 
Dietary Resveratrol (especially from Grape juice) is well-absorbed when consumed orally. references
 
Dosage Recommendations
 
The usual therapeutic dosage of Resveratrol ranges from 4 – 45 mg per day.
 
Commercial Availability of Resveratrol Supplements
 
“Singular” Oral Resveratrol Products
 
Resveratrol is available from health food stores and mail order supplement companies (mainly only in the USA) in the form of:
 
– 10 mg tablets (derived from 500 mg of Japanese Knotweed).
– 10 mg capsules (derived from 50 mg of Japanese Knotweed)
– 15 mg capsules (derived from 100 mg of Japanese Knotweed (20:1 extract) standardized to contain 15% Resveratrol)
loose powder containing 5% Resveratrol derived from Japanese Knotweed
 
Chemical Data
 
Resveratrol is classed as a Phytoalexin.
 
Chemical Names
 
3,4,5-trihydroxystilbene
Trans 3,5,4-trihydroxystilbene
 

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