Reply To: Scripts 2011

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Fund for Innovative Climate and Energy Research (FICER)
Purpose
 
The Fund for Innovative Climate and Energy Research (FICER) exists to accelerate the innovative development and evaluation of science and technology to address carbon dioxide and other greenhouse gas emissions and their environmental consequences.—The non-profit research fund focuses on early-stage innovative research where relatively small and timely grants can significantly advance understanding, especially of the viability and scalability of proposals to address global warming.—Funded research projects are intended to produce peer-reviewed scholarly articles in recognized professional scientific and technical journals. Any intellectual property that may be generated in the course of such research resides with the researchers or their institutions.—Grants for research are provided to the University of Calgary from gifts made by Mr. Bill Gates from his personal funds[U1].—The activities of the Fund for Innovative Climate and Energy Research fall outside the scope of activities of the Bill & Melinda Gates Foundation. FICER is not a Foundation project and has no relationship with it.—The fund has supported research in a wide range of areas. Some examples include:
 
• understanding carbon dioxide emissions associated with international trade in goods and services;
 
• developing technologies to capture carbon dioxide out of the air; and
 
• climate modeling to understand possible environmental consequences of solar radiation management.
 
A select group of diabolic oligarch globalists and their puppet cronies embedded within the United States government are now involved in what some would say are crimes against humanity. These tyrants will stop at nothing to usher their hush, hush global aerosol agenda into full swing.–
According to a report prepared for the Air Force titled “Weather as a Force Multiplier: Owning the WeatherBy 2025” the U.S. Air Force wants to fully control the weather on earth by the year 2025.—Far surpassing even the most horrific act of terror (real or staged), posing as literal gods, these globalists will stop at nothing to control the world by not only controlling the fraudulent banking systems but by owning the weather through a process (blanket term) called Geoengineering.–According to globalist sponsored reports, our planet is in a constant state of threat and is being bombarded with radioactive solar rays increasing planetary temperatures due to human carbon emissions.–However, vast bodies of research now show that that is not the case and that global warming is a another globalist myth, a ponzi scheme to collect a Carbon Tax worldwide, benefitting the very same group behind the curtain.–The myth the global warming “Carbon Tax” pushers have been spouting apparently can only be fixed by spraying deadly toxins in an aerosol particulate form into the earths atmosphere via large sprayer converted aircraft specifically assigned to perform Geoengineering tasks.-Aerosol sprays (slang: Chemtrails) are filled with a variety of chemical and metal compounds and are known to be very hazardous to human, plant, and animal health worldwide. This danger to plant and human and animal health has been documented in films such as “What In the World Are They Spraying” by Michael Murphy & G. Edward Griffin, who have also appeared on the Intel Hub Radio Show with Shepard Ambellas.—Ultimately, this issue was originally a matter for the EPA to rule over considering that they have the authority to sanction geoengineering activities under the National Environmental Policy ACT of 1969. However, documents such as the report to the chairman, Committee of Science and Technology, House of Representatives – “Climate Change” – Sept. 2010, U.S. Gov. Accountability Office which was submitted to all members of congress in 2010 attempt to put control into the hands of even a smaller group of people.—This report clearly is slanted and leans to take control away from the EPA along with other regulatory provisions such as; the Endangered Species ACT, and the Conformity Provision in the Clean Air ACT – total Geoengineering dis-info submitted to members of the Congress and other government branches alike.-The source of most of the dis-info is Obama’s White House Science Czar John P. Holdren. The following was written on USGCRP letterhead;–“January 2011,—Members of Congress–On behalf of the National Science and Technology Council, I am transmitting a copy of Our Changing Planet: The U.S. Global Change Research Program for Fiscal Year 2011. The report describes the activities and plans of the U.S. Global Change Research Program (USGCRP) established under the Global Change Research Act (GCRA) of 1990. The USGCRP coordinates and integrates scientific research on climate and global change and is supported by 13 participating departments and agencies of the U.S. government. This Fiscal Year 2011 edition of Our Changing Planet highlights recent advances and progress made by participating agencies and includes budget information on each agency’s contribution.—This report describes a program in transition. In accordance with the GCRA, the USGCRP agencies requested guidance from the National Research Council on how to best meet the changing needs of the nation to understand climate change and respond to its impacts, and the NRC responded with a 2009 report entitled “Restructuring Federal Climate Research to Meet the Challenges of Climate Change”. In accord with that report’s recommendations, the USGCRP is undergoing a strategic realignment that will ensure that the science produced is maximally useful for decision makers at all scales. As described in the new edition of Our Changing Planet, the program going forward will place greater emphasis on impacts, vulnerabilities, and on understanding the options for adapting to the changing climate. The program will also continue its long-standing support for activities that contribute to a better understanding of the Earth system, including observations, research, and predictive modeling.–All of these focuses will be reflected in the USGCRP’s new strategic plan and its National Climate Assessment.—The USGCRP is committed to its mission to build a knowledge base that informs human responses to global change through coordinated and integrated federal programs of research, education, communication, and decision support. I appreciate the close cooperation of the participating agencies, and I look forward to working with the Congress in the continued development and implementation of this essential national program.—–John P. Holdren Director, Office of Science and Technology Policy Assistant to the President for Science and Technology” – Our Changing Planet–Even more disturbing then that is the fact that your so called representatives have been approving yearly geoengineering budgets in the upwards of billions of dollars per year (as outlined in the document “Our Changing Planet – The US Global Change Research Program for the Fiscal Year of 2011, which is a supplement to the Presidents Budget for 2011, much of which is unaccounted for and not even included in the budget possible signifying even a more nefarious plot involving some black budget.–Back tracking to the year 2001, President elect George W. Bush established the (CCRI) Climate Change Research Initiative. A year later it was made public that the USGCRP or United States Global Change Research program and the CCRI both would become what is known as the (CCSP) Climate Change Science Program. Now, under the Obama Administration the legacy continues to move forward as the USGCRP
 
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Caffeic acid phenethyl ester (CAPE), derived from a honeybee product propolis, exhibits a diversity of anti-tumor effects in pre-clinical models of human breast cancer.
 
Cancer Lett. 2011 Sep 1;308(1):43-53–Authors: Wu J, Omene C, Karkoszka J, Bosland M, Eckard J, Klein CB, Frenkel K
 
Abstract
Breast cancer (BC) patients use alternative and natural remedies more than patients with other malignancies. Specifically, 63-83% use at least one type of alternative medicine and 25-63% use herbals and vitamins. Propolis is a naturopathic honeybee product, and CAPE (caffeic acid phenethyl ester), is a major medicinal component of propolis. CAPE, in a concentration dependent fashion, inhibits MCF-7 (hormone receptor positive, HR+) and MDA-231 (a model of triple negative BC (TNBC) tumor growth, both in vitro and in vivo without much effect on normal mammary cells and strongly influences gene and protein expression. It induces cell cycle arrest, apoptosis and reduces expression of growth and transcription factors, including NF-κB. Notably, CAPE down-regulates mdr-1 gene, considered responsible for the resistance of cancer cells to chemotherapeutic agents. Further, CAPE dose-dependently suppresses VEGF formation by MDA-231 cells and formation of capillary-like tubes by endothelial cells, implicating inhibitory effects on angiogenesis. In conclusion, our results strongly suggest that CAPE inhibits MDA-231 and MCF-7 human breast cancer growth via its apoptotic effects, and modulation of NF-κB, the cell cycle, and angiogenesis.—PMID: 21570765 [PubMed – indexed for MEDLINE]
 
How to take Propolis—To utilize propolis you can take it several ways—in honey—as a tincture or in a warm beverage—any health food store sells it and it should be in a high alcohol base for it to be properly absorbed avoid glycerin tintures –they do not past and the sugar in it may start to actually break down in a year—the alcohol based ones can last years—Recipe (A ) you can propolis from an apiary or a health food store raw and extract your self with anything 120+ proof –add to a glass container and allow to soak for 4 weeks and then blend til smooth and then pour into a container—or take the components of 1- 1 ½ cup of 120 proof and add to a blender and add 3-4 oz of propolis and lid the blender and blend at high speed for 10 minutes—when done pour content in glass bottle and use drop increments—you can add this to tea or coffee –you can mix it in honey—you can combo this with other materials as such like iodine or garlic or even myrrh—the combining is limitless—so explorer
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Science and Religion Do Mix—
Only 15 Percent of Scientists at Major Research Universities See Religion and Science Always in Conflict—ScienceDaily (Sep. 23, 2011) — Throughout history, science and religion have appeared as being in perpetual conflict, but a new study by Rice University suggests that only a minority of scientists at major research universities see religion and science as requiring distinct boundaries.–“When it comes to questions about the meaning of life, ways of understanding reality, origins of Earth and how life developed on it, many have seen religion and science as being at odds and even in irreconcilable conflict,” said Rice sociologist Elaine Howard Ecklund. But a majority of scientists interviewed by Ecklund and colleagues viewed both religion and science as “valid avenues of knowledge” that can bring broader understanding to important questions, she said.—-Ecklund summarized her findings in “Scientists Negotiate Boundaries Between Religion and Science,” which appears in the September issue of the Journal for the Scientific Study of Religion. Her co-authors were sociologists Jerry Park of Baylor University and Katherine Sorrell, a former postbaccalaureate fellow at Rice and current Ph.D. student at the University of Notre Dame.—They interviewed a scientifically selected sample of 275 participants, pulled from a survey of 2,198 tenured and tenure-track faculty in the natural and social sciences at 21 elite U.S. research universities. Only 15 percent of those surveyed view religion and science as always in conflict. Another 15 percent say the two are never in conflict, and 70 percent believe religion and science are only sometimes in conflict. Approximately half of the original survey population expressed some form of religious identity, whereas the other half did not.—“Much of the public believes that as science becomes more prominent, secularization increases and religion decreases,” Ecklund said. “Findings like these among elite scientists, who many individuals believe are most likely to be secular in their beliefs, definitely call into question ideas about the relationship between secularization and science.”—Many of those surveyed cited issues in the public realm (teaching of creationism versus evolution, stem cell research) as reasons for believing there is conflict between the two. The study showed that these individuals generally have a particular kind of religion in mind (and religious people and institutions) when they say that religion and science are in conflict.—The study identified three strategies of action used by these scientists to manage the religion-science boundaries and the circumstances that the two could overlap. Redefining categories — Scientists manage the science-religion relationship by changing the definition of religion, broadening it to include noninstitutionalized forms of spirituality.—Integration models — Scientists deliberately use the views of influential scientists who they believe have successfully integrated their religious and scientific beliefs.–Intentional talk — Scientists actively engage in discussions about the boundaries between science and religion.—“The kind of narrow research available on religion and science seems to ask if they are in conflict or not, when it should really ask the conditions under which they are in conflict,” Ecklund said. “Our research has found that even within the same person, there can be differing views. It’s very important to dispel the myth that people believe that religion and science either do or don’t conflict. Our study found that many people have much more nuanced views.”—These nuanced views often find their way into the classroom, according to those interviewed. One biologist, an atheist not part of any religious tradition, admitted that she makes a sincere effort to present science such that “religious students do not need to compromise their own selves.” Although she is not reconsidering her personal views on religion, she seeks out resources to keep her religious students engaged with science.-Other findings:–Scientists as a whole are substantially different from the American public in how they view teaching “intelligent design” in public schools. Nearly all of the scientists — religious and nonreligious alike — have a negative impression of the theory of intelligent design.–Sixty-eight percent of scientists surveyed consider themselves spiritual to some degree.–Scientists who view themselves as spiritual/religious are less likely to see religion and science in conflict.—Overall, under some circumstances even the most religious of scientists were described in very positive terms by their nonreligious peers; this suggests that the integration of religion and science is not so distasteful to all scientists.–Ecklund said the study’s findings will go far in improving the public’s perception of science. “I think it would be helpful for the public to see what scientists are actually saying about these topics, rather than just believe stereotypes,” she said. “It would definitely benefit public dialogue about the relationship between science and religion.”–Ecklund is the author of “Science vs. Religion: What Scientists Really Think,”published by Oxford University Press last year.—The study was supported by a grant from the John Templeton Foundation and additional funding from Rice University.—Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Rice University. —Journal Reference–Elaine Howard Ecklund, Jerry Z. Park, Katherine L. Sorrell. Scientists Negotiate Boundaries Between Religion and Science. Journal for the Scientific Study of Religion, 2011; 50 (3): 552 DOI: 10.1111/j.1468-5906.2011.01586.x
 
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Aloe Vera Blocked By Canadian Gov’t over a Non Issue
 
Dear Distributors:
 
This is the update on Lily shipping products back into Canada. We have all of the approvals and licenses on our bi-lingual products from the Canadian Health departments, etc. The one area is the site license through MTB Brokerage. From our understanding ALL of the warehouse locations must be listed on the Site License. This was not done originally because none of the inspectors required it; even though technically the statutes require it as such, even the highest levels indicated that was not the intent of the law. Even the original inspector, once we had our labels in compliance, did not require this latest piece. However, we now have a new inspector from another complaint that basically stated that until they change the statute it does not matter to him whether it was not the intent, it is the letter of the law, he has us being required to comply[U2]. Of course, this has caused us further delay in meeting his demands.—We have been placed within the fast lane on getting this corrected. Our hope is to have it in the system and be able to ship next week. This is all very frustrating to us as we have done everything to comply and get our products in compliance but it does seem like we are being required to do things beyond what your government is requiring of other companies. Either way, we have been informed that once this latest is completed and in the system, we can ship. —This is the latest information I have and will keep you updated as I know more.
 
 
Jack Brown
 
Vice President
 
Sales and Marketing
 
800-229-5459
 
 
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Show of the Month October 7 2011
 
Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells
 
The Future of Complementary/Integrative Medicine and patient choice in Canada!
 
Research Points to Potential Therapy for Tumor-Associated Epilepsy
 
Zinc Regulates Communication Between Brain Cells
 
Number of Children Poisoned by Medication Rising Dramatically
 
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Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells.
 
Phytomedicine. 2011 Jan 15;18(2-3):158-62
 
Authors: Weifeng T, Feng S, Xiangji L, Changqing S, Zhiquan Q, Huazhong Z, Peining Y, Yong Y, Mengchao W, Xiaoqing J, Wan-Yee L
 
Artemisinin (ART) is isolated from the medicinal plant Artemisia annua L. To determine its effects on the invasion and metastasis of tumors, the human hepatocellular carcinoma (HCC) cell lines HepG2 and SMMC-7721 were treated with different concentrations of ART. Starting at 12.5μM, ART had inhibitory effects in migration and invasion assays that increased at higher concentrations. The inhibitory effect also became stronger with time, from 24 to 72h. ART significantly inhibited the in vivo metastatic abilities of the HepG2 HCC cell line. ART inhibited the invasion and metastasis of HCC cells both in vitro and in vivo by reducing the level of the MMP2 metalloproteinase, and by inducing the TIMP2 protein. ART activated Cdc42, which enhanced E-cadherin activity, resulting in greater cell-cell adhesion, and significantly reduced metastasis.–PMID: 20739158 [PubMed – indexed for MEDLINE]
 
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From: Dr. Robert Banner
Date: September 5, 2011 10:47:47 AM EDT
To: Robert Banner
Subject: The Future of Complementary/Integrative Medicine and patient choice in Canada!
 
I want to begin by thanking you for opening this message. I encourage you to review the material in the attachments below. This message is being sent to you from my current contacts list from both my personal and professional life.
 
The College of Physicians and Surgeons of Ontario has been in the process of revising the Policy on Complementary Medicine in Ontario. Below you will see responses just submitted on behalf of the Ontario Society of Physicians for Complementary Medicine and the Ontario Medical Association Section on Complementary and Integrative Medicine, the Acupuncture Foundation of Canada, the Coalition for the Advancement of Integrative Medicine, the Lyme Action Group (Ontario) and a letter from an individual (Helke Ferrie) that outlines in detail the concerns regarding the new Draft Policy.–Attached as well are the current policy on Complementary Medicine, the Draft Policy on Complementary Medicine and a “Backgrounder” by the College of Physicians and Surgeons of Ontario.–I believe this issue is truly a national matter with international ramifications. What is about to happen in Ontario will be used as a standard by which other medical licensing bodies in Canada and the United States will begin to curtail/control the practice of medicine. —In Ontario, it will mean the end of MD’s practicing anything other than pharmaceutical medicine and surgery. Physicians and medical students in Ontario who have the ability, will move to another location if they want to practice anything other than the convention or, they will quit practicing integrative medicine altogether. This is leading edge medicine that incorporates many modalities that improve patient outcome and reduce reliance on medications and surgery. This approach not only controls symptoms but also has been shown to resolve the problem.—This is a very serious matter for all of us no matter what your role in the health care field.—Patients need to be able to make informed choices about decisions that will have a significant impact on their lives. Much of health cares upward spiralling health care costs are related to care provided to patients based on the preferences of providers (the College of Physicians and Surgeons of Ontario want to dictate what that will be). When patients are provided with impartial, balanced information regarding health care choices, research has found that they tend to choose less invasive less costly treatments than they might otherwise have selected (Dartmouth Medical School). Informed choice is also closely aligned with the concept of patient autonomy, the concept of informed consent and the value of self-determination that sits at the centre of Canadian and American constitutional liberalism. –The College of Physicians and Surgeons of Ontario seek to take these choices and privileges away from the public. This will be the thin wedge than directs regulators everywhere to act in a similar fashion.–Please feel free to act on this information in whatever way seems best to you, including distribution to anyone else you think might be interested. You may use this email address if you would like to respond, would like more information or if you would like to get involved in any way.–Governments can no longer ignore the will of the public to have a choice in their health care. They must recognize this and control licensing bodies that are supposed to act in the best interest and protection of the public it is supposed to serve. You should be outraged when you read the attachments below. I hope you are.
 
Sincerely,
Rob Banner
 
The best way to thank God for your body is to take good care of it.
The best treatment for any disease is not to get it.
If you want a change, YOU have to change.
I have never learned anything from someone who agreed with me.
There is no medicine as powerful as regular exercise properly done.
 
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Research Points to Potential Therapy for Tumor-Associated Epilepsy
 
ScienceDaily (Sep. 12, 2011) — Glioma, one of the most deadly and common types of brain tumor, is often associated with seizures, but the origins of these seizures and effective treatments for them have been elusive. Now a team funded by the National Institutes of Health has found that human gliomas implanted in mice release excess levels of the brain chemical glutamate, overstimulating neurons near the tumor and triggering seizures.[U1]–The researchers also found that sulfasalazine, a drug on the market for treating certain inflammatory disorders, can reduce seizures in mice with glioma.—About 80 percent of people with glioma will experience at least one seizure during their illness, often as the first symptom. About one-third of patients will develop recurring seizures, known as tumor-associated epilepsy. Sen. Ted Kennedy, D-Mass., whose death was caused by a malignant glioma in August 2009, was diagnosed after having a seizure 15 months earlier.—“Seizures are a frequent symptom of glioma and are often poorly controlled by epilepsy medications,” said Jane Fountain, Ph.D., a program director at NIH’s National Institute of Neurological Disorders and Stroke (NINDS). “Understanding why the seizures occur and how to counteract them could help us substantially improve the quality of life for people with glioma.” “People have assumed that tumors cause seizures by irritating the brain, but that really isn’t a scientific explanation. We have now shown that the seizures are caused by glutamate release from the tumor,” said Harald Sontheimer, Ph.D., a professor of neurobiology and director of the Center for Glial Biology in Medicine at the University of Alabama Birmingham (UAB). Dr. Sontheimer and his team published their results in Nature Medicine.—The research was supported by NINDS, including $934,698 in grants funded through the American Recovery and Reinvestment Act.—Glutamate serves as a chemical relay within the brain. Its release from one neuron can stimulate other neurons to fire electrical impulses. However, excess glutamate can cause abnormal electrical activity in the brain — which is the basis for epileptic seizures. In particular, excess release of glutamate from non-neuronal cells called glia appears to play a role in some types of epilepsy. Because gliomas result from an overgrowth of glia, researchers had theorized that glutamate produced by the tumors might cause seizures, but no one had established a causal link.—Dr. Sontheimer’s team tested the theory by studying mice whose brains were seeded with human glioma cells. They found that about one-third of the animals with gliomas developed abnormal brain activity and behavioral signs consistent with seizures. They also investigated whether or not the tumors affect brain activity in response to stimulation. When they delivered electrical pulses near a tumor, they saw a pattern of activity that spread outward from the tumor and was more prolonged and widespread than the responses to stimulation seen in normal brain tissue. Brain tissue containing the tumors also released higher levels of glutamate compared to normal brain tissue.—Next, the researchers sought to determine if the drug sulfasalazine could correct these abnormalities. Sulfasalazine is an anti-inflammatory sometimes prescribed for ulcerative colitis and rheumatoid arthritis. It also targets a protein complex called the system Xc(-) transporter. System Xc(-) acts like a -commodities broker within glioma cells, importing the essential amino acid cystine into the cells in exchange for exporting glutamate.[U2]–Dr. Sontheimer’s team found that by inhibiting the system Xc(-) transporter, sulfasalazine can reduce glutamate release from gliomas. The drug also reduced seizure activity in the glioma-bearing mice, cutting the frequency of epileptic bursts nearly fivefold in the first hour after treatment. After four hours, the effects of the drug wore off unless it was re-administered. The likely reason is that most of the drug is broken down into a form that does not affect system Xc(-), according to Dr. Sontheimer. A clinical trial is planned at UAB to determine if sulfasalazine can reduce seizures in people with slow-growing gliomas. Meanwhile, Dr. Sontheimer’s lab is working with medicinal chemists to develop a form of the drug that is more stable in the bloodstream and brain, and more active against system Xc(-).—“There is hope that in addition to reducing seizures, sulfasalazine might reduce the growth of glioma cells,” Dr. Sontheimer said. The cystine molecules imported by system Xc(-) are used to manufacture vital proteins that help tumor cells grow stronger, he explained. In a 2005 study, he found that sulfasalazine delays glioma growth in mice.—Whether these promising results with sulfasalazine in animal studies will translate into improved outcome in patients with brain tumors remains to be tested. Indeed, caution was raised by a small trial of 10 patients with advanced stage gliomas treated with varying doses of sulfasalazine. No beneficial effects were established, and safety concerns arose about whether treatment worsened brain swelling near the tumor. That trial was terminated early.—“It is worth examining whether or not the drug can help patients with newly diagnosed, slow-growing gliomas as opposed to patients with advanced disease,” Dr. Sontheimer said.—The lead author of the study, Susan Buckingham, Ph.D., and second author, Susan Campbell, Ph.D., received support from the NINDS Training Program in Brain Tumor Biology at UAB. Vedrana Montana, Ph.D., was hired as a postdoctoral fellow in the Center for Glial Biology in Medicine through Recovery Act funds. The work was also supported by a center core grant from the NIH Blueprint for Neuroscience Research.–
[U1]Taurine Balances out glutamate
[U2]L Cysteine can be gotten from Garlic being fermented and can be bought at any health food store—here are some sources for this as wll Dairy Products: Most Dairy Products contain Cysteine.
Eggs Yolks
Meats: Most Meats contain Cysteine.
Nuts: Most Nuts contain Cysteine.
Seeds: Most Seeds contain Cysteine.
Vegetables: Garlic Onions
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Zinc Regulates Communication Between Brain Cells
 
ScienceDaily (Sep. 21, 2011) — Zinc has been found to play a critical role in regulating communication between cells in the brain, possibly governing the formation of memories and controlling the occurrence of epileptic seizures.—A collaborative project between Duke University Medical Center researchers and chemists at the Massachusetts Institute of Technology has been able to watch zinc in action as it regulates communication between neurons in the hippocampus, where learning and memory processes occur — and where disrupted communication may contribute to epilepsy.—“We discovered that zinc is essential to control the efficiency of communication between two critical populations of nerve cells in the hippocampus,” said James McNamara, M.D., senior author and chair of the Department of Neurobiology at Duke. “This addresses a longstanding controversy in the field.”The study appeared in Neuron Journal online on Sept. 21.—McNamara noted that zinc supplements are commonly sold over the counter to treat several different brain disorders, including depression. It isn’t clear whether these supplements modify zinc content in the brain, or modify the efficiency of communication between these nerve cells.—More than 50 years ago scientists discovered that high concentrations of zinc are contained in a specialized compartment of nerve cells, called vesicles, that package the transmitters which enable nerve cells to communicate. The highest concentrations of brain zinc were found among the neurons of the hippocampus, the center of learning and memory.—Zinc’s presence in these vesicles suggested that zinc played some role in communication between nerve cells, but whether it actually did so remained controversial.—To address this controversy, McNamara and his colleagues at Duke teamed up with Dr. Steve Lippard and colleagues in the Department of Chemistry at the Massachusetts Institute of Technology.–The Lippard team synthesized a novel chemical that bound zinc far more rapidly and selectively than previously available compounds. Use of this chemical let the Duke team rapidly bind the zinc released by nerve cells, taking it out of circulation and preventing enhanced communication.–The Duke team went on to confirm that eliminating zinc from the vesicles of mutant mice also prevented enhanced communication. They also found that increases in the transmitter glutamate seemed to increase zinc-mediated enhancement of communication.—Interestingly, the nerve cells in which the high concentrations of zinc reside are critical for a particular type of memory formation. Excessive enhancement of communication by the zinc-containing nerve cells occurs in epileptic animals and may worsen the severity of the epilepsy.—-“Carefully controlling zinc’s regulation of communication between these nerve cells is critical to both formation of memories and perhaps to occurrence of epileptic seizures,” McNamara said.—McNamara also noted that the scientific collaboration between the Duke and MIT scientists was critical to the success of this work. The availability of the novel chemical provided a critical tool that allowed the neuroscientists to unravel the puzzle.–
Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Duke University Medical Center. –Journal Reference-Enhui Pan, Xiao-an Zhang, Zhen Huang, Artur Krezel, Min Zhao, Christine E. Tinberg, Stephen J. Lippard, James O. McNamara. Vesicular Zinc Promotes Presynaptic and Inhibits Postsynaptic Long-Term Potentiation of Mossy Fiber-CA3 Synapse. Neuron, 2011; 71 (6): 1116 DOI: 10.1016/j.neuron.2011.07.019
 
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Number of Children Poisoned by Medication Rising Dramatically,
ScienceDaily (Sep. 16, 2011) — The number of young children admitted to hospitals or seen in emergency departments because they unintentionally took a potentially toxic dose of medication has risen dramatically in recent years, according to a new Cincinnati Children’s Hospital Medical Center study.—The rise in exposure to prescription products has been so striking that the U.S. Centers for Disease Control and Prevention has established the PROTECT Initiative, intended to prevent unintended medication overdoses in children. Randall Bond, MD, an emergency medicine physician at Cincinnati Children’s, will present his study on children and pharmaceutical poisonings Sept. 20 at a PROTECT Initiative meeting in Atlanta. The study will be published online Sept. 16 in the Journal of Pediatrics.–“The problem of pediatric medication poisoning is getting worse, not better,” says Dr. Bond, who also is medical director of the Drug and Poison Information Center at Cincinnati Children’s. “More children are exposed, more are seen in emergency departments, more are admitted to hospitals, and more are harmed each year.”–Dr. Bond found that exposure to prescription products accounted for most of the emergency visits (55 percent), admissions (76 percent) and significant harm (71 percent). Levels of ingestion of opioids, most often prescribed to treat pain; sedatives-hypnotics, frequently prescribed as sleep aids; and cardiovascular medications were particularly high.—“Prevention efforts at home have been insufficient,” says Dr. Bond. “We need to improve storage devices and child-resistant closures and perhaps require mechanical barriers, such as blister packs. Our efforts can’t ignore society’s problem with opioid and sedative abuse or misuse.” Dr. Bond studied patient records from 2001 to 2008 in the National Poison Data system — an electronic database of all calls to members of the American Association of Poison Control Centers. Dr. Bond studied children 5 years old and younger exposed to a potentially toxic dose of a single pharmaceutical agent, either prescription or over-the-counter. A total of 453,559 children were included in the study.—The largest part of increasing admissions, injuries and death was due to children finding and ingesting medication on their own. Therapeutic errors at home were uncommon and increased only minimally.– The most likely explanation for these trends is a rise in the number of medications around small children, he says. A 1998-99 survey found that half of adults had taken at least one prescription medication in the preceding week and 7 percent had taken five or more. In 2006, the same surveyors found that 55 percent had taken at least one prescription medication in the preceding week and 11 percent had taken five or more.—There are 57 poison control centers in the United States. Together they provide free, 24-hour poison expertise and treatment advice by phone. All poison centers can be reached by calling the same telephone number 1-800-222-1222. Poison centers are staffed by pharmacists, physicians, nurses and poison information providers who are toxicology specialists.
 
The PROTECT Initiative is a collaboration among public health agencies, private sector companies, professional organizations, consumer/patient advocates and academic experts to keep children safe from unintentional medication overdoses. According to the Centers for Disease Control, more than 70,000 emergency visits each year result from unintentional overdoses among children under the age of 18.–Story Source–The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Cincinnati Children’s Hospital Medical Center, via EurekAlert!, a service of AAAS.
 
 
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[U1]BRIBES
[U2]There is Stupidity—there is Lack of brain Cells—and when you look up in the dictionary what being totally brain dead is —then look up under Canadian officials there you will see how we in Canada define stupidity—Start with the PM and go down and when you get to the point of Health inspector in Canada —there is a side note there saying –no such thing exist except in the minds of these people who are trying to create a job—an unnecessary level of gov’t that has the IQ of a pea-and you will see in a sidebar lots of Laughter and tears as a result of the laughter in looking for something in Canada that does Not exist
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Show of the Week October 10 2011
 
Low Vitamin B12 Levels May Lead to Brain Shrinkage, Cognitive Problems
 
Coffee Benefits On Endocrine System Benefits
 
Coffee May Reduce Risk of Lethal Prostate Cancer in Men
 
Coffee Consumption Associated With Reduced Risk of Advanced Prostate Cancer
 
New Analysis of the Cardiovascular Risks of Common Non-Steroidal Anti-Inflammatory Drugs
 
Possible Cardiovascular Risk Found With NSAID Use
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Low Vitamin B12 Levels May Lead to Brain Shrinkage, Cognitive Problems
 
ScienceDaily (Sep. 27, 2011) — Older people with low blood levels of vitamin B12 markers may be more likely to have lower brain volumes and have problems with their thinking skills, according to researchers at Rush University Medical Center. The results of the study are published in the Sept. 27 issue of Neurology, the medical journal of the American Academy of Neurology.–Foods that come from animals, including fish, meat, especially liver, milk, eggs and poultry are usual sources of vitamin B12. –The study involved 121 older residents of the South side of Chicago who are a part of the Chicago Health and Aging Project (CHAP), which is a large, ongoing prospective Rush a biracial cohort of 10,000 subjects over the age of 65. –The 121 participants had blood drawn to measure levels of vitamin B12 and B12-related markers that can indicate a B12 deficiency. The same subjects took tests measuring their memory and other cognitive skills.–An average of four-and-a-half years later, MRI scans of the participants’ brains were taken to measure total brain volume and look for other signs of brain damage.–Having high levels of four of five markers for vitamin B12 deficiency was associated with having lower scores on the cognitive tests and smaller total brain volume.—“Our findings definitely deserve further examination,” said Christine C. Tangney, PhD, associate professor in the department of clinical nutrition at Rush University Medical Center, and lead author of the study. “It’s too early to say whether increasing vitamin B12 levels in older people through diet or supplements could prevent these problems, but it is an interesting question to explore. Findings from a British trial with B vitamin supplementation are also supportive of these outcomes.”–On the cognitive tests, the scores ranged from -2.18 to 1.42, with an average of 0.23. For each increase of one micromole per liter of homocysteine — one of the markers of B12 deficiency — the cognitive scores decreasedby 0.03 standardized units or points[U1].–Tangney noted that the level of vitamin B12 itself in the blood was not associated with cognitive problems or loss in brain volume. She said that low vitamin B12 can be difficult to detect in older people when looking only at blood levels of the vitamin.–“Our findings lend support for the contention that poor vitamin B12 status is a potential risk factor for brain atrophy and may contribute to cognitive impairment,” said Tangney.–Other researchers at Rush involved in the study were Dr. Neelum T. Aggarwal, Hong Li, Robert S. Wilson, PhD, Dr. Denis Evans and Martha Clare Morris, ScD. The study was supported by the National Institute on Aging.–Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Rush University Medical Center, via EurekAlert!, a service of AAAS. —Journal Reference-C. C. Tangney, N. T. Aggarwal, H. Li, R. S. Wilson, C. DeCarli, D. A. Evans, M. C. Morris. Vitamin B12, cognition, and brain MRI measures: A cross-sectional examination. Neurology, 2011; 77 (13): 1276 DOI: 10.1212/WNL.0b013e3182315a33
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Coffee Benefits On Endocrine System Benefits
 
Cancer, Swedish Study Finds Women Who Choose Boiled Coffee Run Lower Risk of Breast
ScienceDaily (June 16, 2010) — Women who drink Scandinavian boiled coffee, which chemically resembles French press and Turkish/Greek coffee, more than four times a day run a lower risk of developing breast cancer than women who drink coffee less than once a day. This is shown by Lena Nilsson and her associates at Umeå University in an article in the journal Cancer Causes & Control. -A major difference between boiled and filtered coffee is that the boiled version contains up to 80 times as much coffee-specific fatty acids. These fatty acids have previously been shown in animal experiments to inhibit the growth of cancer. –By comparing filtered coffee and boiled coffee in the Västerbotten Intervention Project (64,603 participants), researchers at Umeå University have been able to show for the first time that various brewing techniques can lead to different risk patterns for cancer. For total cancer, prostate cancer, colorectal cancer, and many other less common forms of cancer, there was no correlation. Among women who drank boiled coffee more than four times a day there was a lowered risk of breast cancer compared with women who drank coffee less than once a day. Among women who drank filtered coffee there was an increased risk for early breast cancer (under 49 years old) and a decreased risk for late breast cancer (over 55 years old). Boiled-coffee drinkers, but not filtered-coffee drinkers, also had an increased risk of pancreatic cancer and lung cancer among men. The study, recently published in the scientific journal Cancer Causes and Control, is the first in the world to compare the consumption of coffee prepared with two brewing techniques in regard to cancer. -Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Expertanswer, via AlphaGalileo. Journal Reference-Lena Maria Nilsson, Ingegerd Johansson, Per Lenner, Bernt Lindahl, Bethany Guelpen. Consumption of filtered and boiled coffee and the risk of incident cancer: a prospective cohort study. Cancer Causes & Control, 2010; DOI: 10.1007/s10552-010-9582-x
 
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Coffee May Reduce Risk of Lethal Prostate Cancer in Men
 
Men who regularly drink coffee appear to have a lower risk of developing a lethal form of prostate cancer, according to a new study. What’s more, the lower risk was evident among men who drank either regular or decaffeinated coffee. –ScienceDaily (May 18, 2011) — Men who regularly drink coffee appear to have a lower risk of developing a lethal form of prostate cancer, according to a new study led by Harvard School of Public Health (HSPH) researchers. What’s more, the lower risk was evident among men who drank either regular or decaffeinated coffee.–The study was published May 17, 2011, in an online edition of the Journal of the National Cancer Institute. “Few studies have specifically studied the association of coffee intake and the risk of lethal prostate cancer, the form of the disease that is the most critical to prevent. Our study is the largest to date to examine whether coffee could lower the risk of lethal prostate cancer,” said senior author Lorelei Mucci, associate professor of epidemiology at HSPH. Lethal prostate cancer is cancer that causes death or spreads to the bones. Prostate cancer is the most frequently diagnosed form of cancer and the second leading cause of cancer death among U.S. men, affecting one in six men during their lifetime. More than 2 million men in the U.S. and 16 million men worldwide are prostate cancer survivors. “At present we lack an understanding of risk factors that can be changed or controlled to lower the risk of lethal prostate cancer. If our findings are validated, coffee could represent one modifiable factor that may lower the risk of developing the most harmful form of prostate cancer,” said lead author Kathryn Wilson, a research fellow in epidemiology at HSPH. The researchers chose to study coffee because it contains many beneficial compounds that act as antioxidants, reduce inflammation, and regulate insulin, all of which may influence prostate cancer. Coffee has been associated in prior studies with a lower risk of Parkinson’s disease, type 2 diabetes, gallstone disease, and liver cancer or cirrhosis. The study examined the association between coffee consumption and the risk of prostate cancer, particularly the risk for aggressive prostate cancer among 47,911 U.S. men in the Health Professionals Follow-Up Study who reported their coffee consumption every four years from 1986 to 2008. During the study period, 5,035 cases of prostate cancer were reported, including 642 fatal or metastatic cases. Among the findings–Men who consumed the most coffee (six or more cups daily) had nearly a 20% lower risk of developing any form of prostate cancer.–The inverse association with coffee was even stronger for aggressive prostate cancer. Men who drank the most coffee had a 60% lower risk of developing lethal prostate cancer.–The reduction in risk was seen whether the men drank decaffeinated or regular coffee, and does not appear to be due to caffeine.–Even drinking one to three cups of coffee per day was associated with a 30% lower risk of lethal prostate cancer.–Coffee drinkers were more likely to smoke and less likely to exercise, behaviors that may increase advanced prostate cancer risk. These and other lifestyle factors were controlled for in the study and coffee still was associated with a lower risk.–The results from this study need to be validated in additional populations that have a range of coffee exposure and a large number of lethal prostate cancer cases. If confirmed, the data would add to the list of other potential health benefits of coffee. The authors currently are planning additional studies to understand specific mechanisms by which coffee may specifically lower the risk of lethal prostate cancer.–The study was supported by the National Cancer Institute at the National Institutes of Health, the American Institute for Cancer Research, and the Prostate Cancer Foundation.
Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Harvard School of Public Health, via EurekAlert!, a service of AAAS. –Journal Reference-Kathryn M. Wilson, Julie L. Kasperzyk, Jennifer R. Stark, Stacey Kenfield, Rob M. van Dam, Meir J. Stampfer, Edward Giovannucci, Lorelei A. Mucci. Coffee Consumption and Prostate Cancer Risk and Progression in the Health Professionals Follow-up Study. Journal of the National Cancer Institute, May 17, 2011 DOI: 10.1093/jnci/djr151
 
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Coffee Consumption Associated With Reduced Risk of Advanced Prostate Cancer
 
ScienceDaily (Dec. 8, 2009) — While it is too early for physicians to start advising their male patients to take up the habit of regular coffee drinking, data presented at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference revealed a strong inverse association between coffee consumption and the risk of lethal and advanced prostate cancers.–“Coffee has effects on insulin and glucose metabolism as well as sex hormone levels, all of which play a role in prostate cancer. It was plausible that there may be an association between coffee and prostate cancer,” said Kathryn M. Wilson, Ph.D., a postdoctoral fellow at the Channing Laboratory, Harvard Medical School and the Harvard School of Public Health.—In a prospective investigation, Wilson and colleagues found that men who drank the most coffee had a 60 percent lower risk of aggressive prostate cancer than men who did not drink any coffee. This is the first study of its kind to look at both overall risk of prostate cancer and risk of localized, advanced and lethal disease.—“Few studies have looked prospectively at this association, and none have looked at coffee and specific prostate cancer outcomes,” said Wilson. “We specifically looked at different types of prostate cancer, such as advanced vs. localized cancers or high-grade vs. low-grade cancers.”Caffeine is actually not the key factor in this association, according to Wilson. The researchers are unsure which components of the beverage are most important, as coffee contains many biologically active compounds like antioxidants and minerals.–Using the Health Professionals’ Follow-Up Study, the researchers documented the regular and decaffeinated coffee intake of nearly 50,000 men every four years from 1986 to 2006; 4,975 of these men developed prostate cancer over that time. They also examined the cross-sectional association between coffee consumption and levels of circulating hormones in blood samples collected from a subset of men in the cohort.–“Very few lifestyle factors have been consistently associated with prostate cancer risk, especially with risk of aggressive disease, so it would be very exciting if this association is confirmed in other studies,” said Wilson. “Our results do suggest there is no reason to stop drinking coffee out of any concern about prostate cancer.”–This association might also help understand the biology of prostate cancer and possible chemoprevention measures.–Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by American Association for Cancer Research.—
 
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New Analysis of the Cardiovascular Risks of Common Non-Steroidal Anti-Inflammatory Drugs
 
ScienceDaily (Sep. 27, 2011) — An updated study published in PLoS Medicine gives some new information on the cardiovascular risks of non-steroidal anti-inflammatory drugs (NSAIDs) and suggests that among these commonly used drugs, naproxen and low dose ibuprofen are least likely to increase cardiovascular risk whereas diclofenac, even in doses available without prescription, elevates risk. –Using only observational studies (30 case-control studies and 21 cohort studies) because randomised controlled trials have only reported small numbers of cardiovascular events, the authors, Patricia McGettigan (Hull York Medical School, Hull, UK), and David Henry (Institute for Clinical Evaluative Sciences, Toronto, Canada) also found that the new NSAID, etoricoxib, has a high risk of cardiovascular events similar to that of drugs that have been withdrawn because of safety concerns and that new evidence on cardiovascular risk of indomethacin, an older drug, casts doubt on its continued clinical use.—The authors say: “the large sizes of the studies reviewed here, the presence of consistent dose-response relationships, and general agreement with the results of randomised trials give us confidence in the results.” They add: “In our view, the results are sufficiently robust to inform clinical and regulatory decisions.”–This study highlights the importance of adequately assessing drug safety in clinical trials and in an editorial the PLoS Medicine editors write: “debates continue about the best ways to meaningfully synthesize and interpret data on the possible harmful effects of drugs — for example, how passive surveillance systems (spontaneous reports of suspected adverse reactions) should be improved, whether new drugs should go through a phased launch process with enhanced safety evaluation, and the appropriateness of risk mitigation strategies for drugs with safety concerns.”–The editors conclude: “However, these challenges should not detract investigators, regulators, and patients from demanding a higher safety standard for approved drugs. Higher standards will require both greater transparency — in revealing what studies are being conducted and what data have been generated — and greater willingness of funders to support new studies specifically addressing drug safety.”–Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Public Library of Science, via EurekAlert!, a service of AAAS. –Journal References-McGettigan P, Henry D. Cardiovascular Risk with Non-Steroidal Anti-Inflammatory Drugs: Systematic Review of Population-Based Controlled Observational Studies. PLoS Medicine, 2011; 8 (9): e1001098 DOI: 10.1371/journal.pmed.1001098
The PLoS Medicine Editors. Why Drug Safety Should Not Take a Back Seat to Efficacy. PLoS Medicine, 2011; 8 (9): e1001097 DOI: 10.1371/journal.pmed.1001097
 
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Possible Cardiovascular Risk Found With NSAID Use, Study Suggests
 
ScienceDaily (Sep. 26, 2011) — A new study from Rhode Island Hospital researchers suggests that controlling cholesterol may be important for heart health in patients who are taking non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen. The findings are based on a study on the safety of NSAID medications in clinically relevant animal models when high cholesterol is a factor. The study is published in the current issue of the journal Surgery.—NSAIDs are among the most widely-used drugs today for the treatment of post-operative pain, inflammatory conditions and fever. Despite that, the factors that affect their cardiovascular safety are not well understood and some studies suggest that there may be an increased incidence of cardiovascular complications such as heart attack or death.—This study, led by principal investigator Frank Sellke, M.D., chief of cardiothoracic surgery and research at Rhode Island Hospital, developed an animal model of hypercholesterolemia in swine to investigate the formation of collateral vessels and other effects in the heart, and the safety of NSAID and other medications.—Through their study, Sellke says, “We found that a high-cholesterol diet reduced blood flow to the heart muscle in our animal models with chronic heart disease when given daily naproxen. We also found reduced levels of prostacyclin, a compound that dilates blood vessels and prevents blood clots. These findings suggest that there may be a stronger risk of negative effects on the heart in patients who have high cholesterol levels and are taking NSAIDs as a form of pain or inflammation relief.”—The researchers compared two groups within the animal model, one with a normal diet, and one group that received a diet high in cholesterol, and both groups received daily naproxen. The animals also underwent surgery to simulate coronary artery disease, which affects many human patients who take NSAIDs. Several differences were found between the two groups.—Compared to animals with normal cholesterol, the high-cholesterol animals treated with naproxen had lower blood flow to the heart, decreased levels of prostacyclin, and decreased levels of several proteins that promote cardiac cell survival. In addition, previous studies by the group showed that while naproxen helped increased blood flow in the hearts of animals with normal cholesterol, this effect was not seen in animals with high cholesterol. Sellke says, “These results show that high blood cholesterol levels change the way naproxen affects the heart, and alters blood flow to the heart. This ‘myocardial perfusion’ may be one predictor of angina frequency and quality of life in patients with chronic ischemia. Thus, these findings may have important implications for cardiac patients taking NSAIDs.”—First author Louis Chu, M.D., who worked with Sellke on the study, adds, “Our study indicates that physicians should be aware that cholesterol control may be especially important if patients are taking NSAID medications such as naproxen[U2].”—Sellke adds, “While the results of these animal experiments are interesting and may provide information regarding the effect of a high fat diet on the response to naproxen and other similar medications, one cannot make definitive statements on the effect of these medications on patients without first doing clinical studies.”—The study was funded by a grant from the National Institutes of Health. Other researchers involved in the study with Sellke and Chu include Antonio Lassaletta, M.D., Jun Feng, M.D., Ph.D., Robert Heinl, Yuhong Liu, M.D., and Eric Sellke of Rhode Island Hospital and The Warren Alpert Medical School of Brown University and Michael Robich, M.D., and Shu Hua Xu, of Beth Israel Deaconess Medical Center and Harvard Medical School.—Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Lifespan. –Journal Reference-Louis M. Chu, Michael P. Robich, Antonio D. Lassaletta, Jun Feng, Shu Hua Xu, Robert Heinl, Yuhong Liu, Eric Sellke, Frank W. Sellke. High-fat diet alters prostanoid balance and perfusion in ischemic myocardium of naproxen-treated swine. Surgery, 2011; 150 (3): 490 DOI: 10.1016/j.surg.2011.07.022
 
 
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[U1]This is also an indocation of heart deficiency the inability to convert homocystein to cystein this is the cause of heart issue not Cholesterol
[U2]Intreresting thing here is you may not need the drug at all if you are watching the amount of fat you are consuming –in other words the drug is uselss!!
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HOME
 
Show of the Week October 14 2011
 
Judge Denies Basic Property Rights and Fuels Outrage
 
First time proof of sage’s tolerability and efficacy in menopausal women with hot flushes.
 
Baker’s Yeast Substance Can Aid Healing
 
Baker’s Yeast Protects Against Fatal Infections
 
Big Tobacco Knew Radioactive Particles in Cigarettes Posed Cancer Risk but Kept Quiet
 
Herbs For the Spleen- Nutrients For the Spleen things to use to re invigorate the Spleen
 
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Judge Denies Basic Property Rights and Fuels Outrage
 
In a decision denying basic property rights and even exceeding the FDA’s contempt for the rights of private contract and food freedom of choice, Dane County Circuit Court Judge Patrick J. Fiedler has issued an order holding that owners of cows do not have a fundamental right to consume milk from their own cow. —The judge issued the order in response to a motion to clarify an earlier ruling that livestock boarding agreements between a farmer and cow owners were in violation of Wisconsin law. The boarding contracts in question were between Walworth County dairy farmers Mark and Petra Zinniker and the members of Nourished by Nature LLC for a herd of dairy cows as well as between the Zinnikers and Galyle Loiselle and Robert Karp for an individual cow owned by the two. The Zinnikers did not have any ownership in any of the cows and were simply executing a services contract to board, care for and milk the owners’ cows, and provide the milk to the owners.—On August 12, Judge Fiedler issued a ruling denying a motion by the Zinnikers, Nourished by Nature, Karp and Loiselle for a judgment that the boarding agreement the Zinnikers had with the cow owners was in compliance with Wisconsin law. In his opinion the Judge rejected out of hand the Zinniker plaintiffs’ argument that they had a fundamental right to possess, use and enjoy their property (including “a fundamental right to own a cow, and to use their cows in a manner that does not cause harm a third party”); he stated this claim was “wholly without merit.” The judge went on to hold that the plaintiffs were operating a dairy farm and were therefore subject to the requirements of Wisconsin’s dairy code.–Wanting to get more specific reasons for the judge’s dismissal of their rights, the Zinniker plaintiffs filed a Motion for Clarification with the court. —On September 9, Judge Fiedler issued his decision on the motion, stating that the court’s August 12 denial of plaintiffs’ motion for judgment meant the following:
 
(1) Plaintiffs do not have a fundamental right to own and use a dairy cow or a dairy herd;
 
(2) Plaintiffs do not have a fundamental right to consume the milk from their own cow;
 
(3) Plaintiffs do not have a fundamental right to board their cow at the farm of a farmer;
 
(4) The Zinniker Plaintiffs’ private contract does not fall outside the scope of the States’ police power;
 
(5) Plaintiffs do not have a fundamental right to produce and consume the foods of their choice;
 
(6) DATCP [Wisconsin Department of Agriculture, Trade and Consumer Protection] . . . had jurisdiction to regulate the Zinniker Plaintiffs’ conduct.—With this sweeping denial of basic rights, the judge refused to recognize any distinction between public and private activity; moreover, he was holding that the government had the power to regulate people’s efforts to grow and raise their own food. Recently Øin California, the Santa Cruz County Board of Supervisors passed a resolution stating that it “supports, endorses and encourages the recognition of the right and freedom of people to raise their own food, including food derived from agricultural animals, for the enjoyment of themselves and their families, either by their own investment and labor or through the assistance of others through contractual arrangements.” [U1]×Judge Fiedler is holding that when you are raising your own food through a dairy livestock boarding arrangement the state has jurisdiction to meddle in your business–similar to FDA’s views on freedom of food choice.–
The judge’s holding on the lack of basic property rights of cow owners has drawn public outrage. In Wisconsin raw milk activist Max Kane is leading a campaign to have the Wisconsin Judicial Commission investigate Judge Fiedler, encouraging people to file a formal complaint against the judge on the grounds that his ruling was unconstitutional, violating “the fundamental right to life and liberty of farmers and citizens.” Others are pointing to the judge’s decision as another reason to pass a raw milk bill currently before the legislature.–The case will continue in the courts. The Zinnikers plaintiffs filed an appeal of Judge Fiedler’s decision on September 26.
 
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First time proof of sage’s tolerability and efficacy in menopausal women with hot flushes.
 
Adv Ther. 2011 Jun;28(6):490-500—Authors: Bommer S, Klein P, Suter A
 
BACKGROUND: This trial aimed to assess the tolerability and efficacy of a fresh sage preparation in treating hot flushes and other menopausal complaints. Sage (Salvia officinalis) has been traditionally used to treat sweating and menopausal hot flushes, as well as to alleviate associated menopausal symptoms and as a general tonic. However, no clinical studies substantiating the use of sage in menopause have been published previously.
METHODS: In an open, multicenter clinical trial conducted in eight practices in Switzerland, 71 patients (intent-to-treat population [ITT], n=69; with a mean age of 56.4±4.7 years, menopausal for at least 12 months, and with at least five flushes daily) were recruited and treated with a once-daily tablet of fresh sage leaves for 8 weeks after an introductory baseline week. Parameters for the evaluation of efficacy were the change in intensity and frequency of hot flushes, and total score of the mean number of intensity-rated hot flushes (TSIRHF) as determined by diary protocol over the 2-month treatment period. Other variables included assessment of the Menopause Rating Scale (MRS) by the treating physician at baseline and after 2 months of therapy. RESULTS: In the ITT population there was a significant decrease in the TSIRHF by 50% within 4 weeks and by 64% within 8 weeks (P<0.0001). The mean total number of hot flushes per day decreased significantly each week from week 1 to 8. The mean number of mild, moderate, severe, and very severe flushes decreased by 46%, 62%, 79%, and 100% over 8 weeks, respectively. The MRS and its somato-vegetative, psychological, and urogenital subscales decreased significantly by 43%, 43%, 47%, and 20% respectively. The treatment was very well tolerated.— CONCLUSION: A fresh sage preparation demonstrated clinical value in the treatment of hot flushes and associated menopausal symptoms.—MID: 21630133 [PubMed – indexed for MEDLINE]
 
öööPersonnel Note—if they had utilized it more then once a day they may have seen better results as well as the use of living foods and food that have a good dose of liver and kidney support and a good nootropic to assist in brain efficacy
 
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Baker’s Yeast Substance Can Aid Healing, Norwegian Researchers Show
 
ScienceDaily (Sep. 7, 2011) — Can wounds be helped to heal faster? Yes, says a Norwegian company whose product’s active ingredient, beta-glucans, comes from common baker’s yeast.–Beta-glucans have been called nature’s super-medicine. Norwegian researchers have been pioneers in producing these substances from the cell walls of everyday baker’s yeast. Beta-glucans are now widely used in the aquaculture industry and veterinary medicine, as well as in dietary supplements and cosmetics.-The true potential of beta-glucans has barely been touched upon, asserts Rolf Einar Engstad, Chief Scientific Officer at the Tromsø-based company Biotec Pharmacon. He headed a project which over the past several years has enhanced the understanding of how beta-glucans work and how they can be applied.—Promising medicinal effects on humans–“Since the mid-1980s we have known that these substances fight infection and have a bearing on the body’s ability to kill cancerous cells,” explains Dr Engstad, “but we never knew why. With funding from the Programme for User-driven Research-based Innovation (BIA) under the Research Council of Norway, we have carried out a project that gives us insight into the working mechanisms of beta-glucans.” Biotec Pharmacon received assistance from Rikshospitalet University Hospital in Oslo during the project.—“When we started the project we didn’t know whether the substance needed to be taken up in the blood or if its effect was local,” recalls Anders Sandvik, who earned his PhD in beta-glucans.–“To find out, we conducted experiments on rats, introducing bacterial components into the blood to see what would happen. We determined that animals receiving beta-glucan orally acquired protection that was at least as good as rats that received an injection into their bloodstream.”–This was a promising development for the Tromsø company, which had already found that its product, a beta-glucan gel, was effective in helping wounds to heal quickly.–Storage a challenge–
“Some time into the project,” adds Dr Engstad, “we experienced problems maintaining product strength and efficacy. It turned out the gel became unstable after a year in storage. So we added in a new substance during the study that restored the gel’s healing effect.”Now that the project has concluded, Biotec Pharmacon is working on a beta-glucan formula that remains stable during storage. “We’re also examining the possibility of developing the healing gel under the statutory framework for medical devices rather than as a medicine,” says Dr Engstad. “The requirements for clinical documentation of the product are less stringent, and we could get it to market far sooner.”
 
Asthma and allergy treatments next
 
Biotec Pharmacon does not plan to stop at wound healing. The firm eyes even greater potential for beta-glucan ahead. –“Over the past few years, we’ve come to understand that beta-glucan has an effect on our innate immune system, which is the first line of defence in people and in practically every animal. It takes care of 99 per cent of all invasions we are exposed to, and it engages before the human body’s adaptive immune system manages to react.” Many disorders are related to this innate immune system, such as allergies, asthma, chronic fatigue syndromes and cancer. Biotec Pharmacon has been cooperating with Memorial Sloan-Kettering Cancer Center in New York for many years. The Americans have done studies using the beta-glucan from Tromsø on US cancer patients and found that it contributes to the healing effect of antibodies introduced to patients.
 
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Baker’s Yeast Protects Against Fatal Infections
 
ScienceDaily (Aug. 10, 2011) — Injecting mice with simple baker’s yeast protects against the fatal fungal infection, aspergillosis, according to research published in the Journal of Medical Microbiology. The work could lead to the development of a human vaccine that protects immunocompromised people against a range of life-threatening fungal infections, for which current therapy often fails.—Researchers from the California Institute for Medical Research, Santa Clara Valley Medical Center and Stanford University gave mice three injections of killed Saccharomyces (baker’s yeast), one week apart. Vaccinated mice were able to survive high doses of Aspergillus — the fungus that causes aspergillosis. Mice that survived also showed a reduced infection load in their organs.—Aspergillosis is the leading fungal killer among immunocompromised individuals. It is an invasive infection that attacks the lungs, can disseminate to other organs, such as the brain, and can lead to kidney and liver failure. The disease currently has very high mortality as the current available therapy has a high failure rate.—The research team used a simple yeast preparation as a vaccine against Aspergillus in mice. They found that unmodified yeast gave just as much protection against the development of aspergillosis as yeasts that had been engineered to display Aspergillus surface proteins. Dr. David A. Stevens, from Santa Clara Valley Medical Center, in whose laboratory the studies were performed, said, “Our results suggest that the protective component of the yeast is in the cell wall. What’s more, the simple preparation we used has been shown by us to also protect against infection due to three other fungi that cause human disease — Candida, Cryptococcus and Coccidioides.”—Baker’s yeast is being studied by other groups in human clinical trials for other purposes and appears to be safe. “Research to date, including our study, supports the development of a yeast vaccine against all pathogenic fungi that infect humans. Such a ‘panfungal’ vaccine would further reduce mortality in immunocompromised individuals,” explained Dr. Stevens. “While vaccinating all individuals with impaired immune systems would be a formidable challenge, there are certain patient groups that might be the initial target of a vaccine effort. These include transplant candidates, leukemics following induction therapy and also patients diagnosed with solid tumours.” Story Source–The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Society for General Microbiology, via EurekAlert!, a service of AAAS.
 
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Big Tobacco Knew Radioactive Particles in Cigarettes Posed Cancer Risk but Kept Quiet,
 
Tobacco companies knew that cigarette smoke contained radioactive alpha particles for more than four decades and developed “deep and intimate” knowledge of these particles’ cancer-causing potential, but they deliberately kept their findings from the public, according to a new study by UCLA researchers.—The analysis of dozens of previously unexamined internal tobacco industry documents, made available in 1998 as the result of a legal settlement, reveals that the industry was aware of cigarette radioactivity some five years earlier than previously thought and that tobacco companies, concerned about the potential lung cancer risk, began in-depth investigations into the possible effects of radioactivity on smokers as early as the 1960s.—“The documents show that the industry was well aware of the presence of a radioactive substance in tobacco as early as 1959,” the authors write. “Furthermore, the industry was not only cognizant of the potential ‘cancerous growth’ in the lungs of regular smokers, but also did quantitative radiobiological calculations to estimate the long-term lung radiation absorption dose of ionizing alpha particles emitted from cigarette smoke.” The study, published online Sept. 27 in Nicotine & Tobacco Research, the peer-reviewed journal of the Society for Research on Nicotine and Tobacco, adds to a growing body of research detailing the industry’s knowledge of cigarette smoke radioactivity and its efforts to suppress that information.—“They knew that the cigarette smoke was radioactive way back then and that it could potentially result in cancer, and they deliberately kept that information under wraps,” said the study’s first author, Hrayr S. Karagueuzian, a professor of cardiology who conducts research at UCLA’s Cardiovascular Research Laboratory, part of the David Geffen School of Medicine at UCLA. “Specifically, we show here that the industry used misleading statements to obfuscate the hazard of ionizing alpha particles to the lungs of smokers and, more importantly, banned any and all publication on tobacco smoke radioactivity.”—The radioactive substance — which the UCLA study shows was first brought to the attention of the tobacco industry in 1959 — was identified in 1964 as the isotope polonium-210, which emits carcinogenic alpha radiation. Polonium-210 can be found in all commercially available domestic and foreign cigarette brands, Karagueuzian said, and is absorbed by tobacco leaves through naturally occurring radon gas in the atmosphere and through high-phosphate chemical fertilizers used by tobacco growers. The substance is eventually inhaled by smokers into the lungs.—The study outlines the industry’s growing concerns about the cancer risk posed by polonium-210 inhalation and the research that industry scientists conducted over the decades to assess the radioactive isotope’s potential effect on smokers — including one study that quantitatively measured the potential lung burden from radiation exposure in a two-pack-a-day smoker over a two-decade period.–
Karagueuzian and his colleagues made independent calculations using industry and academic data and arrived at results that very closely mirrored those of that industry study, which was conducted nearly a quarter-century ago[U2]. They then compared those results to rates used by the Environmental Protection Agency to estimate lung cancer risk among individuals exposed to similar amounts of alpha particle-emitting radon gas in their homes.–“The gathered data from the documents on the relevant radiobiological parameters of the alpha particles — such as dose, distribution and retention time — permitted us to duplicate the industry’s secretly estimated radiation absorbed dose by regular smokers over a 20- or 25-year period, which equaled 40 to 50 rads,” he said. “These levels of rads, according to the EPA’s estimate of lung cancer risk in residents exposed to radon gas, equal 120 to 138 deaths per 1,000 regular smokers over a 25-year period.”-despite the potential risk of lung cancer, tobacco companies declined to adopt a technique discovered in 1959 and then another developed in 1980 that could have helped eliminate polonium-210 from tobacco, the researchers said. The 1980 technique, known as an acid-wash, was found to be highly effective in removing the radioisotope from tobacco plants, where it forms a water-insoluble complex with the sticky, hair-like structures called trichomes that cover the leaves.[U3]
And while the industry frequently cited concerns over the cost and the possible environmental impact as rationales for not using the acid wash, UCLA researchers uncovered documents that they say indicate the real reason may have been far different.—“The industry was concerned that the acid media would ionize the nicotine, making it more difficult to be absorbed into the brains of smokers and depriving them of that instant nicotine rush that fuels their addiction,” Karagueuzian said. “The industry also were well aware that the curing of the tobacco leaves for more than a one-year period also would not eliminate the polonium-210, which has a half-life of 135 days, from the tobacco leaves because it was derived from its parent, lead-210, which has a half-life of 22 years.”—Karagueuzian said the insoluble alpha particles bind with resins in the cigarette smoke and get stuck and accumulate at the bronchial bifurcations of the lungs, forming “hot spots,” instead of dispersing throughout the lungs. In fact, previous research on lung autopsies in smokers who died of lung cancer showed that malignant growths were primarily located at the same bronchial bifurcations where these hot spots reside.—“We used to think that only the chemicals in the cigarettes were causing lung cancer,” Karagueuzian said. “But the case of the these hot spots, acknowledged by the industry and academia alike, makes a strong case for an increased probability of long-term development of malignancies caused by the alpha particles. If we’re lucky, the alpha particle-irradiated cell dies. If it doesn’t, it could mutate and become cancerous.”–Karagueuzian said the findings are very timely in light of the June 2009 passage of the Family Smoking Prevention and Tobacco Control Act, which grants the U.S. Food and Drug Administration broad authority to regulate and remove harmful substances — with the exception of nicotine — from tobacco products. The UCLA research, he said, makes a strong case that the FDA ought to consider making the removal of alpha particles from tobacco products a top priority.—“Such a move could have a considerable public health impact, due to the public’s graphic perception of radiation hazards,” he said.—To uncover the information, Karagueuzian and his team combed through the internal tobacco industry documents made available online as part of the landmark 1998 Tobacco Master Settlement Agreement. Documents from Philip Morris, R.J. Reynolds, Lorillard, Brown I Williamson, the American Tobacco Company, the Tobacco Institutes and the Council for Tobacco Research, as well as the Bliley documents, were examined, Karagueuzian said.–The team searched for key terms such as “polonium-210,” “atmospheric fallout,” “bronchial epithelium,” “hot particle” and “lung cancer,” among others.—Karagueuzian said the earliest causal link between alpha particles and cancer was made in around 1920, when alpha particle-emitting radium paint was used to paint luminescent numbers on watch dials. The painting was done by hand, and the workers commonly used their lips to produce a point on the tip of the paint brush. Many workers accumulated significant burdens of alpha particles through ingestion and absorption of radium-226 into the bones and subsequently developed jaw and mouth cancers. The practice was eventually discontinued.—Another example involves liver cancer in patients exposed to chronic low-dose internal alpha particles emitted from the poorly soluble deposits of thorium dioxide after receiving the contrast agent Thorotrast. It has been suggested that the liver cancers resulted from point mutations of the tumor suppressor gene p53 by the accumulated alpha particles present in the contrast media. The use of Thorotrast as contrast agent was stopped in the 1950s.[U4]—In addition to Karagueuzian, authors of the study include the late Amos Norman, professor emeritus in the departments of radiation oncology and radiological sciences at UCLA; James Sayre, of the departments of biostatistics and radiological sciences at UCLA; and Celia White, who served from 1999 to 2002 as director of content and services at the Legacy Tobacco Documents Library, which contains more than 13 million documents created by major tobacco companies related to their advertising, manufacturing, marketing, sales and scientific research activities.–The study was funded by the University of California Tobacco-Related Disease Research Program, established by the passage of California’s SB1613 in 1989 to fund a comprehensive University of California grant program to support research into the prevention, causes and treatment of tobacco-related diseases.–Story Source-The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by University of California – Los Angeles Health Sciences, via EurekAlert!, a service of AAAS. –Journal Reference-Hrayr S. Karagueuzian, Celia White, James Sayre, and Amos Norman. Cigarette Smoke Radioactivity and Lung Cancer Risk. Nicotine & Tobacco Research, September 27, 2011 DOI: 10.1093/ntr/ntr145
 
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Herbs For the Spleen- Nutrients For the Spleen
—things to use to re invigorate the Spleen
Spirulina may increase the size of the Spleen (i.e. it stimulates the growth of the Spleen). — Bee Foods–Royal Jelly may increase the number of Cells (Splenocytes) in the Spleen. –Fungi – Edible—Caterpillar Fungus may regenerate the Spleen. –Herbs–Barberry may improve the function of the Spleen, may stimulate the proliferation of Phagocytes within the Spleen and may improve Blood Circulation to the Spleen (due to the Berberine content of Barberry). — Dandelion (root) may stimulate the Spleen. — Echinacea may enhance the function of the Spleen and may increase the weight of the Spleen.
Gentian may improve the function of the Spleen (according to folklore). -Goldenseal may improve the function of the Spleen, may stimulate the proliferation of Phagocytes within the Spleen and may improve Blood Circulation to the Spleen (due to the Berberine content of Goldenseal). —Oregon Grape may improve the function of the Spleen, may stimulate the proliferation of Phagocytes within the Spleen and may improve Blood Circulation to the Spleen (due to the Berberine content of Oregon Grape). –Rehmannia Root-regenerates the Spleen –Mushrooms–Reishi Mushrooms may counteract the atrophy (shrinkage) of the Spleen that inevitably occurs as a result of exposure to Gamma-Rays during Radiation Therapy. –Vegetables–Fennel may improve the function of the Spleen
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With the Herbs you can incorporate them in teas and soups –same with Mushrooms— portion them out based on Volume of liquid –Rule of thumb ( again this is an approximation you can modify it based on results you see at whatever dose that is applicable for effect—remember with herbs or mushrooms it is good to cycle them off for a couple of days every 3-4 weeks for a day or two )
 
Nutrients For the Spleen
Beta-Carotene concentrates in the Spleen.–Lycopene concentrates in the Spleen.
Hormones–Human Growth Hormone (hGH) may be essential for the correct function of the Spleen. –Melatonin may inhibit the atrophy (shrinkage) of the Spleen. —Lipids–Gangliosides concentrate in and are a component of the cells of the Spleen.—Minerals–Cobalt concentrates in the Spleen.( B12 )– Ferritin (the endogenous storage form of Iron—Yellowdock and Rehmannia Root—Beet Juice or the Beet itself—Wine would benefit) concentrates in the Spleen.–Chronic Magnesium deficiency may cause abnormalities in the development of the Spleen. References– Selenium concentrates in the Spleen. ( Consumption of Non irradiated Brazil Nuts )–Zinc concentrates in the Spleen. ( Pumpkin Seeds )-Peptides–Glutathione concentrates in the Spleen.–Smart Drugs–Deprenyl may stimulate the regeneration of Axons associated with Norepinephrine that innervate the Spleen (which may lead to improved cell-mediated Immune System responses). – Vitamins–Inositol concentrates in the Spleen. –Degeneration and atrophy of the Spleen may occur as a result of Vitamin A deficiency: references
 
ØConsuming foods with a red and orange pigments will give you your carotenoids and lycopene—here are some ideas where these can be found
 
Lycopene Sources- Palm Oil (crude) –Fruit-Grapefruit – Pink 3.4–Watermelon references 2.3 – 7.2—Grapes – Red (skins)– Guava 5.4—Papaya –Apricot 0.8 -Herbs-Paprika 2.0 – 5.3–Rose Hips—Processed Foods-Tomato Paste 5.4 – 150.0–Tomato Sauce–6.0 – 18.0–Tomato Juice (canned)-5.0 – 29.9Tomato Powder—120 –Tomato Soup (canned) 2.0 – 5.5–Tomato (canned)9.3 – 12.4–Ketchup–4.2 – 17.2 – Vegetables-Capsicum – Red-Tomato3.1 – 7.7
 
Alpha-Carotene—Sources—Algae-Dunaliella salina –Dietary Oils-Palm Oil (crude) –30—Legumes-Butter Beans-Green Peas (frozen)-0.033–Green Peas (raw) 0.019—Fruit-Kiwi Fruit—Mango—Papaya—Peach—Prunes–Cantaloupe
Apricot-Apples (raw)–0.03–0.005—Blueberries-0.002–Strawberries (raw)-0.005—Vegetables- Carrots (baby, raw) 4.425 Carrots (raw) 4.649
Carrotes (boiled, drained) 4.109 Carrots (frozen, boiled, drained)
5.542–Green Beans (cooked)-0.092-Broccoli-Pumpkin (canned)4.795Pumpking (butternut, baked)–1.130–Brussels Sprouts–Cabbage–Kale–Lettuce–
Sweet Potato -Spinach–Asparagus (raw) 0.012 Avocado (raw)-0.028
Tomato (red, ripe, raw) 0.112 Corn (yellow, sweet, canned)-0.033
 
 
TOP D
[U1]Something is Going on here—the difference between these states should not be that different –a complete 180—maybe this is explaining what is going on California –with the influx of problems and the level of poverty and the stripping of it’s sovereignty—it appears the nationals there are going to force it into submission to the will of the Corporate Finaciers—wisconsins legal system is showing blatantly who they really represent—and this violation of personal rights—we are becoming China—India—Russia Europe-etc..and losing our identity as a separate and free country—even in those countries they are now initiating a life style that once was over here and we are adapting to there previous insanity—and if it did not work for them then it will not work here now!!!
[U2]So then there is No Doubt that this is Valid and that the real culprit may not be nicotine butt Radioactive Materials as a result of Fertilizer used in the processing of the tobacco plants growth
[U3]If you buy your tobacco loose at a store then you may want to apply this method before using!!!
[U4]Might be safe to say they were delivering radiation to people through either tobacco or other materials and that the real causes of the time for cancer might have been radioactive in nature—and there was alot of disinformation about causal effect of illness to save an industry–much like today –the amount of things we are exposed to are more then likelly the cause of the illnesses we are facing—and in light of these findings the medical and gov’t are doing everything in there power to stop your awareness on the cause and the solutions to reversing the damage!!
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HOME
 
Show of the Week October 17 2011
 
Baby Formula- Inflammatory Food Toxins Found in High Levels in Infants
 
The issue of universal immunization from a very broad IMPLICATION
 
AGROCHEMICAL AGRICULTURE THE NEED FOR A SANER ALTERNATIVE
 
Salutation to the Earth Changers
 
Recipe –Pineapple –Lemon-Salt
 
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Baby Formula- Inflammatory Food Toxins Found in High Levels in Infants
 
ScienceDaily (Oct. 6, 2011) — Researchers from Mount Sinai School of Medicine have found high levels of food toxins called Advanced Glycation End products (AGEs) in infants. Excessive food AGEs, through both maternal blood transmission and baby formula, could together significantly increase children’s risk for diseases such as diabetes from a very young age. A second study of AGEs in adults found that cutting back on processed, grilled, and fried foods, which are high in AGEs, may improve insulin resistance in people with diabetes. AGEs — toxic glucose byproducts previously tied to high blood sugar — are found in most heated foods and, in great excess, in commercial infant formulas.—[U1]The first report, published in Diabetes Care in December 2010, showed that AGEs can be elevated as early as at birth, indicating that infants are highly susceptible to the inflammation associated with insulin resistance and diabetes later in life. Helen Vlassara, MD, Professor and Director of the Division of Experimental Diabetes and Aging, working with Jaime Uribarri, MD, Professor of Medicine and colleagues at Mount Sinai School of Medicine, looked at 60 women and their infants to see if there was a passive transfer of AGEs from the blood of mothers to their babies. They found that newborn infants, expected to be practically AGE-free, had levels of AGEs in their blood as high as their adult mothers.[U2] Within the first year of life, after switching from breast milk onto commercial formulas, the infants’ AGEs had doubled to levels seen in people with diabetes, and many had elevated insulin levels. Formulas that are processed under high heat can contain 100 times more AGEs than human breast milk, delivering a huge AGE surplus to infants, which could be toxic.”Modern food AGEs can overwhelm the body’s defenses, a worrisome fact especially for young children,” said Dr. Vlassara. “More research is certainly needed, but the findings confirm our studies in genetic animal models of diabetes. Given the rise in the incidence of diabetes in children, safe and low cost AGE-less approaches to children’s diet should be considered by clinicians and families.”—The work led to a second report in Diabetes Care, in July 2011, which demonstrates that a modest cut in foods high in AGEs may improve insulin resistance in adults with diabetes. AGEs were found to be elevated in most grilled, fried, or baked foods. Cutting back on the consumption of foods that are heat-processed, but without reducing fat or carbohydrate consumption, improved insulin levels and overall health in patients already treated for, but remaining, insulin resistant.[U3] The findings are a dramatic departure from standard clinical recommendations for the management of diabetes.–For four months, 18 overweight people with type 2 diabetes and 18 healthy adults were assigned to an AGE-restricted diet or a standard diet consisting of the same calories and nutrients they ingested before beginning the AGE-restricted diet. An AGE-restricted diet emphasizes poached or stewed foods, such as mashed potatoes instead of fries, stewed chicken instead of grilled chicken, and boiled eggs instead of fried eggs.–The results showed that the subjects with diabetes assigned to the AGE-restricted diet had a 35 percent decrease in blood insulin levels, well beyond that achieved by their previous therapeutic regimen. This was associated with improved markers of inflammation and a restoration of compromised native defenses. This is the first study to show in humans that AGEs promote insulin resistance and possibly diabetes. The study also shows for the first time that restricting the amount of AGEs consumed with food may quickly restore the body’s defenses and reduce insulin resistance.–“This clinical study begins to expose the double role food AGEs play in obesity and in diabetes, a major concern for everyone today, particularly young children. It is especially exciting that a simple intervention such as AGE-restriction or future drugs that block AGE absorption could have a positive effect on these epidemics,” said Dr. Vlassara. “The tenets of the diet could not be simpler; turn down the heat, add water, and eat more at home.”—Story Source–The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by The Mount Sinai Hospital / Mount Sinai School of Medicine, via EurekAlert!, a service of AAAS. –Journal References–J. Uribarri, W. Cai, M. Ramdas, S. Goodman, R. Pyzik, X. Chen, L. Zhu, G. E. Striker, H. Vlassara. Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes: Potential role of AGER1 and SIRT1. Diabetes Care, 2011; 34 (7): 1610 DOI: 10.2337/dc11-0091 V. Mericq, C. Piccardo, W. Cai, X. Chen, L. Zhu, G. E. Striker, H. Vlassara, J. Uribarri. Maternally Transmitted and Food-Derived Glycotoxins: A factor preconditioning the young to diabetes? Diabetes Care, 2010; 33 (10): 2232 DOI: 10.2337/dc10-1058

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