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Show of the Week December 23 2011
 
Grapefruit compound may boost diabetic kidney health
 
Pine bark extract shows brain health benefits
 
Probiotics may boost immune health markers for smokers
 
Creatine can fight fatty liver disease
 
Coffee may offer womb cancer protection, say Harvard researchers
 
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Grapefruit compound may boost diabetic kidney health
 
Supplementing the diet with naringenin, a compound from grapefruit, may reduce markers of inflammation and boost kidney health in diabetics, suggests data from a study with mice. —- Naringenin, responsible for the bitter taste in grapefruits, lemon and tomatoes, has already been reported to offer potential benefits for people with diabetes, arteriosclerosis and hyper-metabolism. — The new study, published in the Journal of Agricultural and Food Chemistry, adds to this body of science, and suggests that the compound may boost kidney health in people with diabetes. Diabetic renal injury (diabetic nephropathy) is just one potential complication of diabetes, and it has been suggested that inflammation may contribute to its development. —- Taiwanese researchers now report that supplementing the diet of lab mice with 2% naringenin may reduce levels of various inflammatory markers, such as of interleukin (IL)-1beta and IL-6, as well as reducing the activity of a protein called nuclear factor kappa-B (NF-kappaB), which is known to be play a key role in some inflammatory pathways. —“Although naringenin at 2% exhibited effective anti-inflammatory and antifibrotic activities in diabetic mice, further studies are necessary to examine its safety before it is used for humans,” wrote the researchers. –Study details — The researchers tested the potential kidney protecting effects of naringenin at doses of 0.5, 1, and 2% of the diet. — Results showed that diabetic mice consuming the higher doses of the compound displayed decreased blood sugar levels, and increased insulin levels, compared to the control (no naringenin) mice. — In addition, various markers of inflammation were significantly reduced, including IL-1beta and IL-6 reductions of 45% for the 2%-fed animals. — “These results indicated that this compound attenuated renal inflammatory injury via down-regulation of these inflammatory mediators,” wrote the researchers. — While most of the anti-inflammatory effects were observed in a dose-dependent manner, only the 2% group displayed lower activity of NF-kappaB, said the researchers. —“This compound […]suppressed NF-kappa B activation,” wrote the researchers. “Therefore, supplementation with this agent or foods rich in this compound might be helpful for the prevention or alleviation of diabetic nephropathy.” Source: Journal of Agricultural and Food Chemistry Published online ahead of print, doi: 10.1021/jf203259h “Anti-inflammatory and Antifibrotic Effects of Naringenin in Diabetic Mice” Authors: S-J. Tsai, C-S. Huang, M-C. Mong, W-Y. Kam, H-Y. Huang, M-C. Yin
 
Recipe MSM + Citrus Whites ( Bioflavonoids) –take the peels of any citrus ( dry them or fresh ) add to a blender say 4-8 slices—add MSM 5 grams pulverize together and add to either fluids or add to capsules to further utilize the benfits of both in the reduction of toxic metals and reverese glyacation of the cells and to protect the body’s respiratory system-liver and intestinal trac
 
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Pine bark extract shows brain health benefits
 
Daily supplements of a French maritime pine bark extract may enhance mental performance, according to a new study with Italian university students. — A daily dose of the branded ingredient Pycnogenol for eight weeks was associated with improvements in alertness, memory and mood, according to findings published in the PubMed-listed journal Panminerva Medica. Researchers from Pescara University propose that the extract’s benefits may be linked to improvements in blood flow to the brain. –“The study we present here is the first to investigate the effects of Pycnogenol in […] young healthy students,” wrote researchers, led by Dr Gianni Belcaro. “Pycnogenol statistically performed better than controls in a wide series of cognitive performance tests consciously selected evaluating sustained attention, episodic memory, spatial working memory, mental flexibility and planning. “More interestingly, in this study the cognitive performance of the subjects was evaluated in a real challenging situation like the university examinations,” they added. —-Study details –= The Italian researchers recruited 108 Italian university students aged between 18 and 27, and randomly assigned them to receive either a daily 100 mg dose of Pycnogenol or placebo for eight weeks. Computer-assisted methods were used to assess the students’ mental performance. — Results showed that student in the Pycnogenol group showed improvements in attention, memory and mood, while levels of anxiety decreased by 17%. — According to Dr Balcaro and his co-workers, the benefits of the supplements may be related to the antioxidant potency of the ingredient, as well as improved blood circulation. –“This study indicates a role for Pycnogenol to improve cognitive function in normal students,” wrote the researchers. —“It may be the beginning of a series of studies indicating possible uses of Pycnogenol for cognition.” Previous data— The study adds to an earlier study with the pine bark extract in seniors. Results published in the Journal of Psychopharmacology by scientists from Swinburne University in Melbourne, Australia, indicated that a daily dose of 150mg of Pycnogenol over a three month period produced “significantly improved” memory scores in the subjects. Source: Panminerva Medica 2011, Volume 53, Supplement 1 to No. 3, Pages 75-82 “Pycnogenol supplementation improves cognitive function, attention and mental performance in students” Authors: R. Luzzi, G. Belcaro, C. Zulli, M. R. Cesarone, U. Cornelli, M. Dugall, M. Hosoi, B. Feragallo
 
Recipe Pine Bark Tea—go into the woods or in an area where pine grows and pick out branches ( do not kill of trees ) and use even the needles in soups or teas and make teas with this—use maple syrup to offset the bitterness—combining this with the whites ( bioflavonoids) will also increase the protection of the brain as well
 
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Probiotics may boost immune health markers for smokers
 
Daily supplements of the probiotic Lactobacillus casei Shirota strain may boost activity of key immune cells in smokers, says a new study.
While quitting smoking is obviously the best option to improve health, researchers from Italy and Japan report that smokers may benefit from a daily probiotic to boost the activity of natural killer (NK) cells, a key component of the immune system. — According to a paper published in the British Journal of Nutrition, increased activity of these NK cells is associated with healthy body and mind, and therefore boosting NK activity using dietary approaches if “most desirable”. “Smoking habit and alcohol consumption are the two most important preventable causes of disease and premature death,” wrote researchers from the University ‘G. d’Annunzio’ in Italy, and the Nippon Medical School and Osaka University Graduate School of Medicine in Japan. –“Despite increasing knowledge of their hazard, prevalence is declining very slowly and their decrease appears to be limited to the higher socio-economic class among populations. –“Smoking threats are not limited to the immunosuppressive effect, but have a major health impact. Thus, despite the LcS increase of NK activity, a concerted effort to quit smoking is the only way to real prevention of cancer and [cardiovascular disease (CVD)].” —Probiotics According the FAO/WHO, probiotics are defined as “live microorganisms which when administered in adequate amounts confer a health benefit on the host”. — The new study used Yakult’s strain and the Japanese company provided the powder preparations used in this study. Study details -For the new study, the researchers recruited 72 Italian male smokers and randomly assigned them to receive either a daily probiotic (40 billion lyophilized viable cells of Lactobacillus casei Shirota strain) or placebo for three weeks. — Participants of the double-blind, placebo-controlled, randomized study had an average age of 50, and they were described as healthy. Results showed that men receiving the probiotic experienced increases in the activity of their NK cells of 17 to 26%, compared with 8.4 to 10.5% in the placebo group. —“Furthermore, Lactobacillus casei Shirotastrain treatment appeared to reduce the perception of nausea and stomach-ache symptoms, reflecting an improvement of gastrointestinal functions possibly result in from a restored microbiota balance,” wrote the researchers. —“Although it is well established that ingested Lactobacillus casei Shirota strain transits alive through the stomach and survives in the intestine, it is still unclear as to how Lactobacillus casei Shirota strain may improve the upper gastrointestinal tract symptoms, such as nausea or stomach-ache. “Direct interaction of LcS with the stomach or indirect action through hormonal or nervous regulation may be assumed and may represent future research subjects.” –Take home -“Since smokers exhibit higher susceptibility to infections and inflammatory diseases and NK cells play an important role in controlling infections and eliminating aberrant cells, dietary supplementation with Lactobacillus casei Shirota strain could contribute to increased NK cytotoxic activity with significant health advantages for individuals with smoking habits.–“However, these results should not be interpreted as an attempt to overcome smoke-related damages, but on the contrary they strengthen the notion of tobacco interference with the immune system,” they concluded. — Source: British Journal of Nutrition Published online ahead of print, doi: 10.1017/S0007114511005630 “Daily intake of Lactobacillus casei Shirota increases natural killer cell activity in smokers” Authros: M. Reale, P. Boscolo, V. Bellante, C. Tarantelli, M. Di Nicola, L. Forcella, Q. Li, K. Morimoto, R. Muraro
 
Recipe For Smoking and Protection—Consuming Porbiotic enriched foods and adding to this NAC 500mgs—and Vitamin C 1000mgs several times a day may improve the protective impact against smoking
 
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Creatine can fight fatty liver disease -NAFLD
 
A team on international researchers has found that the sports nutrient, creatine, can help prevent the build-up of fat in the liver in rats on high-fat diets. Published in the October issue of the Journal of Nutrition, the study found rats fed a high-fat diet (71% calories derived from fat, 18% protein, 11% carbohydrate) and supplemented with creatine had reduced liver problems compared to control groups after three weeks. — After three weeks, liver samples were assessed for their contents of fat, creatine, and other substances thought to be involved in nonalcoholic fatty liver disease. — Non-alcoholic liver health measures such as cellular oxidative stress associated with inflammation; reduced S-adenosylmethionine (SAM) levels (a compound linked to immunity) and healthy neural activity were all improved in the creatine group. “The difference in fat accumulation between liver sections from the HF and HFC groups was confirmed by image analysis. Ingestion of the HF diet increased plasma glucose, which was partially reversed by creatine supplementation. The plasma insulin concentration did not differ among the groups.” — The researchers, from Memorial University of Newfoundland, the University of Sao Paulo and the University of Alberta highlighted the affect of creatine on peroxisome proliferator-activated receptors (PPARs) – nuclear receptor proteins involved in the regulation of the expression of genes. The authors said PPARs were crucial in preventing steatosis and fat-related oxidative stress and inflammation via effects on fatty acid catabolism. –‘To the best of our knowledge, our study is the first to demonstrate the regulation of PPARs expression and its downstream targets by creatine.” However they acknowledged that the dosages among the rats (3.1g/kg) was significantly higher than that typically used in human tests (0.3g/kg). -Relevance — UK-based creatine researcher Dr Mark Tallon, PhD, from the NutriSciences consultancy, agreed it was difficult to extrapolate the results of the animal study to humans. -“They are interesting findings but how relevant are they to humans?” Dr Tallon wondered. –“We know rats metabolise fats in a different way to humans as evident in studies looking at medium chain triglycerides and their use as a fuel source and conjugated linoleic acid (CLA) as a weight management aid. Is a ‘71% calories from fat’ diet externally valid in relation to the way humans consume food – I would suggest not. Therefore, the study is interesting if you’re a rat on a high fat diet.” Source— Journal of Nutrition October 2011 (141:1799-1804, 2011.) ‘Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet’ – Authors: Deminice R, da Silva RP, Lamarre SG, Brown C, Furey GN, McCarter SA, Jordae AA, Kelly KB, King-Jones K, Jacobs RL, Brosnan ME, Brosnan JT.
 
Recipe-Creatine + Taurine+ MilkThistle—take 5 grams of creatine -1-2 grams of Taurine and mix with a Milk Thistle tea to increase the potency of the creatine and Taurine to be a effective battle for NAFLD ( Non Alcoholic Fatty Liver Diseases ) and do this several times a day—this will increase liver Support –insulin regulating and brain health as well
 
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Coffee may offer womb cancer protection, say Harvard researchers
 
Long-term coffee consumption may be associated with up to a 25% reduced risk of womb (endometrial) cancer, according to new research.
The study – published in Cancer Epidemiology, Biomarkers & Prevention – reports that consumption of more than four cups of coffee per day is linked with a 25% reduced risk of developing endometrial cancer. Drinking between two and three cups per day was associated with a 7% reduction in risk, said the researchers, led by Professor Edward Giovannucci of the Harvard School of Public Health, USA. Giovannucci, explained that coffee is emerging as a protective agent in cancers that are linked to obesity, estrogen and insulin. –“Coffee has already been shown to be protective against diabetes due to its effect on insulin,” he said, noting that his team believed such benefits may also be true of certain cancers that are linked to insulin. “Drinking of coffee, given its widespread consumption, might be an additional strategy to reduce endometrial cancer risk,” said the researchers. However they noted that the addition of substantial sugar and cream to coffee “could offset any potential benefit.” –Study details — The research team investigated the association between cumulative coffee intake and endometrial cancer risk in a population of 67,470 women who enrolled in the Nurses’ Health Study. During the course of 26 years of follow-up, the team documented 672 cases of endometrial cancer. – The team reported that consumption of fewer than four cups of coffee per day was not associated with endometrial cancer risk. –“However, women who consumed four or more cups of coffee had 25% lower risk of endometrial cancer than those who consumed less than one cup per day,” they said. — A similar association was found for decaffeinated coffee, said the research team, who found that drinking more than two cups per day was linked with a 22% reduced risk for endometrial cancer. They added that tea consumption was not associated with endometrial cancer risk. — Giovannucci said he hopes this study will lead to further inquiries about the effect of coffee on cancer – noting that further research is needed because this and similar studies reporting benefits from coffee consumption use methodology where coffee intake is self-selected and not randomised.
Source: Cancer Epidemiology, Biomarkers & Prevention
Published online ahead of print, doi: 10.1158/1055-9965.EPI-11-0766
“A Prospective Cohort Study of Coffee Consumption and Risk of Endometrial Cancer over a 26-Year Follow-Up”– Authors : Y. Je, S.E. Hankinson, S.S. Tworoger, I. DeVivo, E. Giovannucci
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Show of the Week December 26 2011
Do Our Medicines Boost Pathogens?
 
Cobblers Pegs, Farmers Friend
 
Healing Serious Bone Injuries Faster Than Ever Before
 
Natural pesticides and bioactive components in foods.
 
Essential Fatty Acids Pill Prevents PMS
 
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Do Our Medicines Boost Pathogens?
 
ScienceDaily (Dec. 21, 2011) — Scientists of the Institute of Tropical Medicine (ITG) discovered a parasite that not only had developed resistance against a common medicine, but at the same time had become better in withstanding the human immune system. With some exaggeration: medical practice helped in developing a superbug. For it appears the battle against the drug also armed the bug better against its host.– “To our knowledge it is the first time such a doubly armed organism appears in nature,” says researcher Manu Vanaerschot, who obtained a PhD for his detective work at ITG and Antwerp University. “It certainly makes you think.”—Vanaerschot studies the Leishmania parasite, a unicellular organism that has amazed scientists before. Leishmania is an expert in adaptation to different environments, and the only known organism in nature disregarding a basic rule of biology: that chromosomes ought to come in pairs. (The latter was also discovered by ITG-scientists recently.) The parasite causes leishmaniasis, one of the most important parasitic diseases after malaria. It hits some two million people, in 88 countries — including European ones — and yearly kills fifty thousand of them. The parasite is transmitted by the bite of a sand fly. The combined resistance against a medicine and the human immune system emerged in Leishmania donovani, the species causing the deadly form of the disease.—On the Indian subcontinent, where most cases occur, the disease was treated for decades with antimony compounds. As was to be expected, the parasite adapted to the constant drug pressure, and evolved into a form resisting the antimonials. In 2006 the treatment was switched to another medicine, because two patients out of three did not respond to the treatment. The antimonials closely work together with the human immune system to kill the parasite. This probably has given Leishmania donovani the opportunity to arm itself against both. It not only became resistant against the drug, but also resists better to the macrophages of its host.[U1] Macrophages are important cells of our immune system.–There is no absolute proof yet (among other things, because one obviously cannot experiment on humans) but everything suggests that resistant Leishmania not only survive better in humans — have a higher “fitness” — but also are better at making people ill — have a higher “virulence” — than their non-resistant counterparts.
 
Superbug? –It is the first time that science finds an organism that always benefits from its resistance. Normally resistance is only useful when a pathogen is bombarded by drugs; the rest of the time it is detrimental to the organism.
Resistant organisms are a real problem to medicine. More and more pathogens become resistant to our drugs and antibiotics — to a large extend because you and I use them too lavishly and improperly. For several microbes, the arsenal of available drugs and antibiotics has so diminished that people may die again from pneumonia, or even from ulcerating wounds. Luckily for us, resistance helps pathogens only in a drug-filled environment. In the open field their resistance is a disadvantage to them, because they have to invest energy and resources into a property with no use there. Just like a suit of armour is quite useful on the battle field, but a real nuisance the rest of the time.–So the propagation of resistant organisms is substantially slowed down because they are at a disadvantage outside of sick rooms. But this rule, too, is violated by Leishmania: even in absence of the drug, the resistant parasite survives better, instead of worse, and it is more virulent than a non-resistant parasite.—Did our medicines create a superbug? A legitimate question, and the phenomenon has to be investigated, but this sole case doesn’t imply we better stop developing new medicines (as a matter of fact, the antimony-resistant Leishmania are still susceptible to a more recent drug, miltefosine). On the contrary, we should develop more new drugs, to give new answers to the adaptive strategies of pathogens, and we should protect those drugs, for instance by using them in combination therapies. In this never-ending arms race we should use our drugs wisely, to minimise the chances for pathogens to develop resistance.—Story Source-The above story is reprinted from materials provided by Institute of Tropical Medicine Antwerp.–
 
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Cobblers Pegs, Farmers Friend …Bidens Pilosa—Family: ASTERACEAE
 
Cobblers Pegs – Bidens Pilosa— Of all the wild food available in Australia the Cobblers Peg, otherwise called Farmers Friend because the seed sticks to you, would have to be amongst the most unpopular with folk who work in gardens.
And yet, in many other parts of the world – mainly the Southern hemisphere interestingly enough, it is a popular and widely-used foodstuff and medicine. It’s therapeutic uses are extraordinarily comprehensive (as the list below demonstrates). — As a foodstuff, it is in daily use as a vegetable in Africa. The leaves can be dried and stored for the future or cooked. Some folks advise draining and refreshing the water often during cooking to purge the bitterness from the taste. We use the leaves straight from the plant in salads or direct to the mouth and experience no bitterness. The taste is a slightly nutty flavour and, like all herbs, our bodies will tell us exactly and unambiguously when we have eaten enough in one session. —
 
The extraordinarily-efficient barbs of the seeds— We had a drive full of Cobblers Pegs when we first arrived here at Middle Path, but found that when we applied a few applications of rock powder to the area where they where growing, they didn’t come back. Nature has an amazing way of restoring the balance. Wherever our neighbours spray chemicals there come up the Cobblers Pegs like a lawn doing their utmost to restore balance again. — A friend of mine sent for some seeds of a particular herb overseas which was known to be excellent for stomach ulcers. When she got the seeds, she laughed, it was Cobblers Pegs. — This weed is rich in minerals and especially Calcium which is the great healer for stomach ulcers. —- Cobblers Pegs can be dried and used as a herbal tea as well as a vegetable source.
 
These conditions below have been successfully treated with Cobblers Pegs in different parts of the world:
 
abortiive
allergies
angina
antidote
anti-inflammatory
antiseptic
baldness
biliousness
blood clots
boils
bronchitis
burns
cancer
candida
catarrh
cold
colic
colitis
breast engorgement
burns
cataracts
catarrh
chills
childbirth
colitis
conjunctivitis
constipation
cough
cystitis
dental pain
diaper
rash
diabetes
diarrhea
diuretic
dropsy
dysentery
earache
edema
emmenagogue
eyes
fever
flatulence
food poisoning
fungal
infections
gastroenteritis
glands
gout
infections
gonorrhea
heat-rash itch
headache
hemorrhoids
hemorrhage
hepatitis
hypoglycemic
insect bites
intestinal infections
jaundice
kidneys
lacerations
laryngitis
inflammation
leucorrhea
liver
liver obstructions
low blood pressure
lungs
malaria
mouth
blisters
nephritis
nervous problems
nervous
shock
parasites
pharynx
pneumonia
postpartum hemorrhage
prostate tumors
obesity
rage
respiratory
rheumatism
scurvy
snakebite
sores
sore mouth
sore throat
stomach pains
stomach-ache
stimulant
thrush
thorax
tonsillitis
toothache
tuberculosis
vaginal infections
ulcerated colitis
ulcers
urinary infections
venereal diseases
vomiting
worms
wounds
 
Some of the other names it is known by (around the world):
Kinehi / Ko’oko’olau [Hawai’i]
Xian Feng Cao (“Abundant Weed”), Gui Zhen Cao (“Demon Spike Grass” or “Ghost Needle Weed”) [China]
Aceitilla [Spanish]
Amor Seco (Desmodium adscendens is also called “Amor Seco”) [Peru]
Beggars Tick / Spanish Needle / Needle Grass [USA]
Black Jack [South Africa]
Cobblers Peg, Farmer’s Friend [Australia]
Fisi ‘Uli [Tonga]
Has Kung Chia, Han Feng Cao [Taiwan]
Muni [Aymara, Quechua]
Ottrancedi [India]
Picao preto, Cuamba [Brazil]
Piripiri [Cook Islands]
Saetilla, Sillk’iwa [Quechua]
Sanana Vinillo, Saytilla, Natilluna [Bolivia]
Spanish Needle, Needle Grass [Barbados, St. Thomas]
Te de Coral [Mexico]
Z’Herbe Zedruite [Caribbean]
Fisi’uli [Tonga]
Uqadolo [Southern Africa]
Z’Herbe Zedruite, Z’Herbe Z’Aiguille [Dominica, Martinique]
 
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Healing Serious Bone Injuries Faster Than Ever Before
 
ScienceDaily (Dec. 13, 2011) — A human-made package filled with nature’s bone-building ingredients delivers the goods over time and space to heal serious bone injuries faster than products currently available, Cleveland researchers have found.—Tested on sheep in Switzerland, the surgical elastic “implant device,” essentially a wrapping that mimics bone’s own sock-like sheath called periosteum, delivered stem cells, growth factors and other natural components of the periosteum to heal a defect that would not heal on its own if left untreated. In experimental groups exhibiting best outcomes, a dense network of new bone filled the defect, from the surgical elastic wrapping on the outside towards the steel intramedullary nail that stabilized the bone on the inside, bridging old with new bone.—Melissa Knothe Tate, a joint professor of biomedical engineering and mechanical & aerospace engineering at Case Western Reserve University; Ulf Knothe, an orthopedic surgeon at the Cleveland Clinic, as well as Hana Chang and Shannon Moore, graduate students in Knothe Tate’s lab, report their work in a recent issue of PLoS ONE.–“We’re trying to use the methods Mother Nature uses to generate bone,” Knothe Tate said.—The device is modeled after the periosteum, the sock-like covering of bone, which is filled with stem cells and growth factors that, given the right cues, grow bone. Knothe Tate and her husband, Knothe, reported last year that bridging a bone injury with periosteum healed bone faster than any currently used methods, in testing on sheep and in limited clinical cases.–But, often there is too little of the periosteal covering left to fully cover the gap after a traumatic injury.[U2]
Based on what they’d learned, Knothe Tate built a version of periosteum out of two elastic sheets, approved by the FDA for surgery. She left one intact and perforated the other in a gradient with most holes across the center of the sheet and fewer the farther from the center.—She sewed the sheets together using surgical sutures as thread, with the perforated sheet on the inside. The suture seams create a series of pockets, left open at what would be the top and bottom of the device. The device is sutured to the healthy tissue like a patch and provides a path for movement of cells and bone building materials upward, downwards and inwards.—The researchers filled the pockets of one set of the devices with membranes made of collagen, which is a natural component of the periosteum; a second set was filled with collagen membranes seeded with cells that reside in the periosteum [U3], and a third set with strips of periosteum. Both the collagen seeded sheets and the periosteum strips tucked into the pockets showed the most promising results for bridging of critical sized defects that do not heal on their own.—The pockets filled with natural periosteal strips, although no longer connected to a blood supply, provided the ingredients to grow bone quickly, densely, and completely in a group of five adult sheep, Knothe Tate said.—In addition to providing the ingredients at the right place and time, the device, along with the nail, act as a template for the new growth.—“This really blurs the line between an implant and a delivery system,” Knothe Tate said.–Depending on how she directs growth, the device can grow bone two ways found in nature. Much of the skeleton forms as cartilage first then turns to bone before birth, while the skull grows directly from stem cells into bone.–Beyond bone, the device is flexible enough to be used in a broad array of applications, Knothe Tate said. Potential uses include growing cartilage for orthopedics, to fuse vertebrae, as a delivery system for stem cells, antibiotics, transcription factors and more.—Story Source-The above story is reprinted from materials provided by Case Western Reserve University.
Journal Reference-Melissa L. Knothe Tate, Hana Chang, Shannon R. Moore, Ulf R. Knothe. Surgical Membranes as Directional Delivery Devices to Generate Tissue: Testing in an Ovine Critical Sized Defect Model. PLoS ONE, 2011; 6 (12): e28702 DOI: 10.1371/journal.pone.0028702
 
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Natural pesticides and bioactive components in foods.
 
Abstract
 
In this review, some common food plants and their toxic or otherwise bioactive components and mycotoxin contaminants have been considered. Crucifers contain naturally occurring components that are goitrogenic, [U4]resulting from the combined action of allyl isothiocyanate, goitrin, and thiocyanate. Although crucifers may provide some protection from cancer when taken prior to a carcinogen, when taken after a carcinogen they act as promoters of carcinogenesis. The acid-condensed mixture of indole-3-carbinol (a component of crucifers) binds to the TCDD receptor and causes responses similar to those of TCDD. Herbs contain many biologically active components, with more than 20% of the commercially prepared human drugs coming from these plants. Onion and garlic juices can help to prevent the rise of serum cholesterol. Most herbs used in treatments may have many natural constituents that act oppositely from their intended use. Some herbs like Bishop’s week seed contain carcinogens, and many contain pyrrolizidine alkaloids that can cause cirrhosis of the liver. The general phytoalexin response in plants (including potatoes, tomatoes, peppers, eggplant, celery, and sweet potatoes) induced by external stimuli can increase the concentrations of toxic chemical constituents in those plants. In potatoes, two major indigenous compounds are alpha-solanine and alpha-chaconine, which are human plasma cholinesterase inhibitors and teratogens in animals. Because of its toxicity, the potato variety Lenape was withdrawn from the market. Celery, parsley, and parsnips contain the linear furanocoumarin phytoalexins psoralen, bergapten, and xanthotoxin that can cause photosensitization and also are photomutagenic and photocarcinogenic. Celery field workers and handlers continually have photosensitization problems as a result of these indigenous celery furanocoumarins. A new celery cultivar (a result of plant breeding to produce a more pest-resistant variety) was responsible for significant incidences of phytophotodermatitis of grocery employees. Since there is no regulatory agency or body designated to oversee potential toxicological issues associated with naturally occurring toxicants, photodermatitis continues to occur from celery exposure. Sweet potatoes contain phytoalexins that can cause lung edema and are hepatotoxic to mice. At least one of these, 4-ipomeanol, can cause extensive lung clara cell necrosis and can increase the severity of pneumonia in mice. Some phytoalexins in sweet potatoes are hepatotoxic and nephrotoxic to mice. The common mushroom Agaricus bisporus contains benzyl alcohol as its most abundant volatile, and A. bisporus and Gyromitra esculenta both contain hydrazine analogues. Mycotoxins are found in corn, cottonseed, fruits, grains, grain sorghums, and nuts (especially peanuts); therefore, they also occur in apple juice, bread, [U5]peanut butter, and other products made from contaminated starting materials.(ABSTRACT TRUNCATED AT 400 WORDS)
 
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Essential Fatty Acids Pill Prevents PMS
 
ScienceDaily (Jan. 16, 2011) — A pill containing a mix of essential fatty acids has been shown to significantly reduce the symptoms of premenstrual syndrome (PMS). Researchers writing in BioMed Central’s open access journal Reproductive Health tested the tablets by carrying out a randomised, controlled trial in 120 women.–Edilberto Rocha Filho worked with a team of researchers from the Federal University of Pernambuco, Brazil, to conduct the tests. He said, “The administration of 1 or 2 grams of essential fatty acids to patients with PMS resulted in a significant decrease in symptom scores. Furthermore, the administration of the dietary supplement did not result in any changes in the total cholesterol in the patients evaluated.”—Women who were given capsules containing 2 grams of a combination of gamma linolenic acid, oleic acid, linoleic acid, other polyunsaturated acids and vitamin E [U6]reported significantly eased PMS symptoms at both 3 and 6 months after they began the treatment. Few adverse events were recorded and these were mild, insignificant and did not appear to be directly related to the medication.—Speaking about the results, Rocha Filho said, “The negative effect of PMS on a woman’s routine activities and quality of life may be significant, in addition to the repercussions on economic costs resulting predominantly from a reduction in productivity. Essential [fatty acids] capsules can now be said to show much promise as a treatment.”—Story Source-The above story is reprinted from materials provided by BioMed Central, via EurekAlert!, a service of AAAS. —Journal Reference-Edilberto A Rocha Filho, José C Lima, João S Pinho Neto, Ulisses Montarroyos. Essential fatty acids for premenstrual syndrome and their effect on prolactin and total cholesterol levels: a randomized, double blind, placebo-controlled study. Reproductive Health, 2011; 8 (1): 2 DOI: 10.1186/1742-4755-8-2
 
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[U1]Seems like the genetics of the parasites are being coersed to develop—making the host more susceptible to being infected—makes you wonder how these parasites became so intelligent—and how there programming allows for this kind of adaption—makes you consider—could they have been helped?
[U2]Periosteum -The dense fibrous membrane covering the surface of bones except at the joints and serving as an attachment for muscles and tendons.
[U3]Gelatin anyone–
[U4]goitrogenic –Thyroid disrupting—iodine depleting—or hormonal imbalancing
[U5]This is why preparing foods properly will be important—a lot of these things that are naturally occurring in nature –“ being Au Natural” can be lethal unless you know how to neutralize the parts you are going to eat—consuming some of the cruciferious veges can be beneficial but sometimes steaming or high spotting heat to prepare can be adequate to reduce or remove the defence mechanism of the plants that can be dangerous
[U6]Omega 6 oils and omega 9
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Show of the Week December 30 2011
 
The Top 12 Cancer-Causing products in the Average Home
 
Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles
 
How Food Affects Genes
 
Choline may help protect the brain from effects of ageing- Recipe for brain Enhancements
 
Recipe for Making your own EFA’s
 
 
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Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles.
 
Sex Transm Dis. 2011 Jul;38(7):667-71
 
Authors: Cybulska P, Thakur SD, Foster BC, Scott IM, Leduc RI, Arnason JT, Dillon JA
 
Abstract
BACKGROUND: Neisseria gonorrhoeae (Ng) has developed resistance to most antimicrobial agents and the antibiotics recommended for therapy are restricted, for the most part, to third generation cephalosporins. In order to investigate new potential sources of antimicrobial agents, the antibacterial properties of 14 Canadian plants used in traditional First Nations’ medicine were tested against Ng isolates having differing antimicrobial susceptibility profiles.
METHODS: Ethanolic extracts of 14 Canadian botanicals, analyzed by high-performance liquid chromatography, were tested for their antimicrobial activity (disc diffusion and/or agar dilution assays) against susceptible Ng reference strains and a panel of 28 Ng isolates with various antimicrobial resistance profiles. RESULTS: Extracts of Arctostaphylos uva ursi (kinnikinnick or bearberry), Hydrastis canadensis (goldenseal), Prunus serotina (black cherry), and Rhodiola rosea (roseroot) inhibited the growth of all Ng isolates with minimum inhibitory concentrations of 32 μg/mL, 4 to 32 μg/mL, 16 to >32 μg/mL, and 32 to 64 μg/mL, respectively. Extracts of Acorus americanus (sweet flag), Berberis vulgaris (barberry), Cimicifuga racemosa (black cohosh), Equisetum arvense (field horsetail), Gaultheria procumbens (wintergreen), Ledum groenlandicum (Labrador tea), Ledum palustre (marsh Labrador tea), Oenothera biennis (common evening primrose), Sambucus nigra (elderberry), and Zanthoxylum americanum (prickly ash) had weak or no antimicrobial activity against the Ng isolates with minimum inhibitory concentrations ≥256 μg/mL. The phytochemical berberine from H. canadensis inhibited the growth of all Ng isolates. The phytochemicals, salidroside and rosavin, present in R. rosea, also showed inhibitory activity against Ng strains.– CONCLUSION: Canadian botanicals represent a potential source of novel compounds which inhibit Ng, including isolates resistant to antibiotics.—PMID: 21301385 [PubMed – indexed for MEDLINE]
 
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How Food Affects Genes
 
Tiny RNA molecules in food eaten can circulate in the bloodstream and turn genes off in the body; what are the implications of eating genetically modified food?
Dr. Mae-Wan Ho
 
Nucleic acids circulating in the bloodstream and Darwin’s theory of pangenesis
 
The age-old adage that you are what you eat has taken a literal turn in the rush of startling findings since the human genome sequence was announced 10 years ago, which overturn every tenet of the genetic determinist ideology that had made the Human Genome Project seem a compelling undertaking —-In 2009, we reported on nucleic acids circulating in the bloodstream that offer golden opportunities for disease diagnosis, and may also play a role in communication between cells within an organism [3] (Intercommunication via Circulating Nucleic Acids, SiS 42). –But would circulating nucleic acids cross species barriers? Yes, according to Liu Yongshen at the Henan Institute of Science and Technology in Xinxiang, China [4]. Furthermore, Charles Darwin was really the first person to have proposed a mechanism for it in his theory of pangenesis. —Darwin’s theory of pangenesis suggested that all cells of an organism shed minute particles, gemmules, which circulate throughout the body and are passed on to the next generation through the germ cells. In that way, the characteristics of the parents are passed on to their offspring. And if the cells of the parents undergo changes during their life time, those changes would also be transmitted to the offspring. Liu described Darwin’s theory of pangenesis in some detail and reviewed both historical and more recent evidence in support of it, including fascinating findings on transmission of characteristics through blood transfusion that have been expurgated from the mainstream account. He concluded that [4]: “a considerable revision of views on Darwin’s Pangenesis must occur before a new comprehensive genetic theory can be achieved.”
Question are raised the potential dangers of genetically modified (GM) nucleic acids in GM food being taken up by cells in our body. –Now, a team of researchers in China have documented just this possibility. Plant nucleic acids are found to survive digestion in the gut, escape into the bloodstream, and taken up into the liver cells to target a very specific gene for silencing [6].—MicroRNAs a new class of signalling molecules between cells-Zhang Chen-Yu and colleagues at Nanjing University, National University of Defence Technology, Changsha, and Tianjin Medical University, have been researching stable microRNAs, which they found circulating in the bloodstream of mammals that are actively secreted from the tissues and cells in the body. In a paper published in 2008 [7], the team presented results suggesting that the miRNAs could serve as a novel class of biomarkers for disease, and later showed that they could act as signaling molecules in intercellular communication.—MicroRNAs (miRNAa) are a class of 19-24 nucleotide long non-coding RNAs that silence an estimated 30 percent of protein-coding genes in mammals after the genes are transcribed. They do so by pairing, usually with complementary sequences in the 3’ untranslated regions (UTRs) of the targeted gene transcripts. The targeted genes are involved in a range of vital functions including cell differentiation, apoptosis (programmed cell death), cell proliferation, the immune response, and the maintenance of cell and tissue identity. Dysregulation of miRNAs is linked to cancer and other diseases; and specific miRNA profiles in the blood are potential biomarkers for diagnosis. —Zhang and colleagues had characterized the possible carriers of circulating miRNAs as microvesicles (MVs) shed from almost every cell type under both normal and pathological conditions (rather like Darwin’s gemmules). The MVs carry surface receptors and ligands of the original cells and have the potential to selectively interact with specific target cells to transport lipids, mRNA, proteins, or other signalling molecules between cells. Many MVs also contain miRNAs that could be selectively packaged and delivered into recipient cells where they regulate the expression of target genes and recipient cell function. In other words, miRNAs can serve as a novel class of signaling molecules between cells in the same organism.–To their surprise, Zhang and colleagues found plant miRNAs in the serum and plasma of humans and other mammals [6]. More than half of the plant miRNAs detected are present in MVs. In an extensive series of experiments, they showed that a particularly abundant plant miRNA, MIR168a, can pass through the mouse gut and enter the bloodstream, ending up in various organs especially the liver, where it regulates a specific protein, LDLRAP1, involved in low density lipoprotein uptake.
 
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Choline may help protect the brain from effects of ageing
 
Increased dietary intake of choline may be related to better cognitive performance and protection against memory loss.— The study – published in the American Journal of Clinical Nutrition – points towards correlation between memory and dietary choline – found in such as saltwater fish, eggs, liver, chicken, milk and certain legumes, including soy( Not suggested ) and kidney beans and sunflower seeds– after researchers found that people with high intakes of choline performed better on memory tests, and were less likely to show brain changes associated with dementia. — The researchers, led by senior researcher Rhoda Au of Boston University School of Medicine, USA, said that their results do not mean that choline is the answer to staving off Alzheimer’s disease, but noted that the findings do add to evidence that nutrition plays a role in the aging of the brain. — However, Au cautioned against looking to any one nutrient as a magic bullet against dementia. [U1]–Diet-dementia link — A number of studies have reported links between diet and nutrition and the risk of developing Alzheimer’s disease. — The authors noted that choline is the precursor to the neurotransmitter acetylcholine, and as such has attracted attention as a possibly important nutrient to stave off cognitive decline. They added that the loss of cholinergic neurons is associated with impaired cognitive function – particularly memory loss and Alzheimer disease (AD). —Study details Au and her colleagues analysed population data from the long-running Framingham study. Nearly 1,400 adults aged between 36 and 83 completed a food-frequency questionnaire and then underwent tests of memory and other cognitive abilities, including MRI brain scans. — In general, Au and her team found that men and women who reported high choline intake performed better on the memory tests than those who reported lower intake – however the researchers said that the differences in test performance were small. —“As far as your day-to-day functioning, it would not be an appreciable difference,” said Au. — However, she added, the findings suggest that people with lower choline intakes are more likely to be on a ‘pathway’ toward mental decline than their counterparts with higher intakes. In addition, the team found that people with higher choline intake at the outset were less likely to show areas of “white-matter hyperintensity” – areas believed to be a sign of blood vessel disease – in their MRI brain scans. — Au reiterated that none of the results prove that choline, per se, protects memory or unhealthy brain changes associated with aging. One possibility, she noted, is that some other nutrients present along with choline are responsible for the effects seen. — She added that further studies in humans are needed to back up the current findings. — Source: American Journal of Clinical Nutrition Volume 94, Number 6, pages 1584-1591 , doi: 10.3945/​ajcn.110.008938 “The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort”Authors: C. Poly, J.M. Massaro, S. Seshadri, P.A. Wolf, E. Cho, E. Krall, P.F. Jacques, R. Au
 
Recipe for brain Enhancements—Utilize Choline + Piracetam + Dmae in a ratio of 2:1:1 piracetam 2-choline 1-dmae 1 and you can see the enhancements of thought processes increase—memory retained-analytical thinking increase—a wakening of a dullness
 
Using Lugols iodine 1-4 drops a day will increase brain acquity as well as mood and endurance mentally
 
Consuming Sunflower lecithin or Egg Yolk Lecithin and wheat germ oil will increase brain and coordination
 
Drinking Caffeinated Beverages plus adding b12 1000mcgs-5000mcgs and B1 100mgs –can as well see an increase in brain efficiency
 
Eating nuts and seeds high in saturated fats and omega 6 fats will increase brain health as well as increase phosphorus which is needed fro brain functionality—several tsp daily
 
Coffee does the same as gingko or periwinkle as far as oxygenating the brain and increasing alertness—you can as well utilize ephedrine 8mgs + caffeine 100mgs ( 1 cup of a 14 oz volume)—or take the essential oil of peppermint ( 1 drop ) and add to black coffee
 
The use of nootropics will as well make a huge difference on brain functionality
 
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Recipe for Making your own EFA’s
 
Add 1 part Omega 3 ( walnut oil—chia seed oil—periwinkle oil )
Add 2 parts omega 6 ( evening primrose-sesame seed-sunflower seed-borage-peanut-almond-apricot-any one or any combo to get a 2 part ratio )
Add 1 part of omega 9 ( olive oil-macadamia nut oil-pumpkin seed oil )
Add either essential oil of rosemary or sage or thyme or savoury or oregano –to act as an antioxidant
 
Use 1 tsp several times a day or as needed
 
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TOP I
[U1]I agree—with the many biochemcials in the brain we need to utilize synergy to offset the imbalances and a lot of times it does take more then one thing—but the most part it requires we eliminate the things that are causing the damage to begin with!!
[U2]Omega 6 oils and omega 9

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