Toxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line.
Biol Res. 2010;43(4):429-37—Authors: Votto AP, Domingues BS, de Souza MM, da Silva Júnior FM, Caldas SS, Filgueira DM, Clementin RM, Primel EG, Vallochi AL, Furlong EB, Trindade GS
Abstract–Onion (Allium cepa) is being studied as a potential anticancer agent, but little is known regarding its effect in multidrug resistance (MDR) cells. In this work, the cytotoxicity of crude onion extract (OE) and fractioned extract (aqueous, methanolic and ethyl acetate), as well as some onion compounds (quercetin and propyl disulfide) were evaluated in Lucena MDR human erythroleukemic and its K562 parental cell line. The capacity of OE to induce apoptosis and/or necrosis in these cells, the possible participation of oxidative stress and DNA damage were also assessed. Similar sensitivities were obtained for both tumoral cells, however only OE caused significant effects in the cells. In K562 cells, a significant increase of apoptosis was verified while the Lucena cells experienced a significant increase of necrosis. An antioxidant capacity was verified for OE discarding oxidative damage. However, OE provoked similar significant DNA damage in both cell lines. Thus, the OE capacity to overcome the MDR phenotype suggests anti-MDR action of OE.—PMID: 21526269 [PubMed – indexed for MEDLINE]
Recipe—for an Onion Extract
Making an Onion Extract—you can juice an onion and then fuse in alcohol-brandy-or any clear based alcohol ( ethanol )
You can extract in a juice then fuse with vinegar and add alcohol as well—
Bottle these in glass when doing them and date them—serving size –start off with ½ tsp doses several times a day ( 1-5 ) and either increase strength of dose or increase the amount taken throughout the day
Astragaloside IV and cycloastragenol stimulate the phosphorylation of extracellular signal-regulated protein kinase in multiple cell types.
Planta Med. 2012 Jan;78(2):115-21—Authors: Yung LY, Lam WS, Ho MK, Hu Y, Ip FC, Pang H, Chin AC, Harley CB, Ip NY, Wong YH
Abstract—Two Chinese herb-derived small molecule telomerase activators, astragaloside IV (AG-IV) and cycloastragenol (CAG), have recently been shown to improve the proliferative response of CD8+ T lymphocytes from HIV-infected patients by upregulating telomerase activity. Here, we examined the signaling mechanism of AG-IV and CAG. Telomerase activity in human embryonic kidney HEK293 fibroblasts was increased upon treatment with increasing concentrations of AG-IV or CAG. Both compounds induced the phosphorylation of extracellular signal-regulated protein kinase (ERK) in a time- and dose-dependent manner in HEK293 cells and HEK-neo keratinocytes. AG-IV and CAG also stimulated ERK phosphorylation in other cell lines of lung, brain, mammary, endothelial, and hematopoietic origins. Use of selective inhibitors and dominant negative mutants revealed the involvement of c-Src, MEK (ERK kinase), and epidermal growth factor receptor in CAG-induced ERK phosphorylation. Our data indicate that AG-IV and CAG may exert their cellular effects through the activation of the Src/MEK/ERK pathway.–PMID: 22083896 [PubMed – indexed for MEDLINE]
[U1]Not only minority—any family of any ethnic background—-this profiling here shows ignorance —this could be suggested that non minority may have some immunity to this and that would be erroneous —especially in today’s thinking
Show Of the Week July 23 2012
Attacking Biofilms That Cause Chronic Infections
Gates Poisoning Africa With Vaccines
Composition- efficacy, and safety of spinach extracts
Pressurized liquid extraction of flavonoids from spinach
Vitamin E May Lower Liver Cancer Risk
Attacking Biofilms That Cause Chronic Infections
3-D reconstruction of the bacterial biofilm made by cholera bacteria. Bacterial cells (blue) attach to surfaces with a glue-like protein (green) and cement themselves together with another protein (gray). The bacterial clusters then cover themselves with a protective shell (red) made of proteins and sugar molecules.
ScienceDaily (July 12, 2012) — A clever new imaging technique discovered at the University of California, Berkeley, reveals a possible plan of attack for many bacterial diseases, such as cholera, lung infections in cystic fibrosis patients and even chronic sinusitis, that form biofilms that make them resistant to antibiotics.—By devising a new fluorescent labeling strategy and employing super-resolution light microscopy, the researchers were able to examine the structure of sticky plaques called bacterial biofilms that make these infections so tenacious. They also identified genetic targets for potential drugs that could break up the bacterial community and expose the bugs to the killing power of antibiotics.–“Eventually, we want to make these bugs homeless,” said lead researcher Veysel Berk, a postdoctoral fellow in the Department of Physics and the California Institute for Quantitative Biosciences (QB3) at UC Berkeley.—Berk and his co-authors, including Nobel laureate and former UC Berkeley professor Steven Chu, report their findings in the July 13 issue of the journal Science.—“In their natural habitat, 99.9 percent of all bacteria live as a community and attach to surfaces as biofilms; according to the National Institutes of Health, 80 percent of all infections in humans are related to biofilms,” Berk said.—The researchers were able to employ new techniques that allowed them to zoom into a street-level view of these biofilms, where they learned “how they grow from a single cell and come together to form rooms and whole buildings,” Berk said. “Now, we can come up with a logical approach to discovering how to take down their building, or prevent them from forming the building itself.”–Combining super-resolution microscopy with the technique Berk developed, which allows continuous labeling of growing and dividing cells in culture, biologists in many fields will be able to record stop-motion video of “how bacteria build their castles,” he said.–“This work has led to new insights into the development of these complex structures and will no doubt pave the way to new approaches to fighting infectious disease and also bacteriological applications in environmental and industrial settings,” said Chu, a former UC Berkeley professor of physics and of molecular and cell biology and former director of the Lawrence Berkeley National Laboratory.
Bacteria are not loners—The popular view of bacteria is that they are free-living organisms easily kept in check by antibiotics, Berk said. But scientists now realize that bacteria spend most of their lives in colonies or biofilms, even in the human body. While single bacteria may be susceptible to antibiotics, the films can be 1,000 times more resistant and most can only be removed surgically.—Implants, such as pacemakers, stents and artificial joints, occasionally become infected by bacteria that form biofilms. These biofilm sites periodically shed bacteria — adventurers, Berk calls them — which can ignite acute infections and fever. While antibiotics can knock out these free-swimming bacteria and temporally calm down the infection, the biofilm remains untouched. The only permanent solution is removal of the biofilm-coated device and replacement with a new sterilized implant.—A permanent bacterial biofilm in the sinuses can ignite an immune response leading to chronic sinus infections, with symptoms including fever and cold-like symptoms. So far, the most effective treatment is to surgically remove the affected tissue.–Bacteria also form permanent, mostly lifelong, biofilms in the mucus-filled lungs of cystic fibrosis patients and are responsible for the chronic lung infections that lead to early death. Although long-lasting antibiotic treatment helps, it cannot eradicate the infection completely.—To study a biofilm formed by cholera bacteria (Vibrio cholerae), Berk built his own super-resolution microscope in the basement of UC Berkeley’s Stanley Hall based on a 2007 design by coauthor Xiaowei Zhuang, Chu’s former post-doctoral student who is now a professor at Harvard University. To actually see these cells as they divided to form “castles,” Berk devised a new technique called continuous immunostaining that allowed him to track four separate target molecules by means of four separate fluorescent dyes.—He discovered that, over a period of about six hours, a single bacterium laid down a glue to attach itself to a surface, then divided into daughter cells, making certain to cement each daughter to itself before splitting in two. The daughters continued to divide until they formed a cluster — like a brick and mortar building — at which point the bacteria secreted a protein that encased the cluster like the shell of a building.—The clusters are separated by microchannels that may allow nutrients in and waste out, Berk said.—“If we can find a drug to get rid of the glue protein, we can move the building as a whole. Or if we can get rid of the cement protein, we can dissolve everything and collapse the building, providing antibiotic access,” Berk said. “These can be targets for site-specific, antibiotic medicines in the future.”[U1]
Super-resolution microscopy– painting with light–Berk is a biologist trained in physics and optics with expertise in imaging the structures of proteins: He was part of a team that a few years ago determined the atomic-scale structures of the ribosome, the cellular machine that translates genetic message into a finished protein.—-He suspected that powerful new super-resolution light microscopy could reveal the unknown structure of biofilms. Super-resolution microscopy obtains 10 times better resolution than standard light microscopy — 20 instead of 200 nanometers — by highlighting only part of the image at a time using photo-switchable probes and compiling thousands of images into a single snapshot. The process is much like painting with light — shining a flashlight beam on a dark scene while leaving the camera shutter open. Each snapshot may take a few minutes to compile, but for slow cellular growth, that’s quick enough to obtain a stop-action movie.–The problem was how to label the cells with fluorescent dyes to continuously monitor their growth and division. Normally, biologists attach primary antibodies to cells, then flood the cells with fluorescent dye attached to a secondary antibody that latches onto the primary. They then flush away the excess dye, shine light on the dyed cells and photograph the fluorescence.—Berk suspected that a critically balanced concentration of fluorescent stain — low enough to prevent background, but high enough to have efficient staining — would work just as well and eliminate the need to flush out excess dye for fear it would create a background glow.—“The classical approach is first staining, then destaining, then taking only a single snapshot,” Berk said. “We found a way to do staining and keep all the fluorescent probes inside the solution while we do the imaging, so we can continuously monitor everything, starting from a single cell all the way to a mature biofilm. Instead of one snapshot, we are recording a whole movie.”–“It was a very simple, cool idea, but everyone thought it was crazy,” he said. “Yes, it was crazy, but it worked.”—-Berk’s coauthors are Steven Chu, now with the U.S. Department of Energy; Jan Liphardt, UC Berkeley professor of physics and of molecular and cell biology; Xiaowei Zhuang and Graham T. Dempsey of Harvard; Jiunn C. N. Fong and Fitnat H. Yildiz of UC Santa Cruz; and Omer N. Develioglu of Taksim Research Hospital in Istanbul, Turkey.–Story Source-The above story is reprinted from materials provided by University of California – Berkeley. –Journal Reference-Veysel Berk, Jiunn C. N. Fong, Graham T. Dempsey, Omer N. Develioglu, Xiaowei Zhuang, Jan Liphardt, Fitnat H. Yildiz, Steven Chu. Molecular Architecture and Assembly Principles of Vibrio cholerae Biofilms. Science, 13 July 2012: Vol. 337 no. 6091 pp. 236-239 DOI: 10.1126/science.1222981
Gates Poisoning Africa With Vaccines
Melinda Gates has just unrolled her new program to reduce population in Africa and South Asia. Speaking at the Family Planning Summit in London, the other half of the Gates-Messiah operation pledged to bring contraception to millions of women and girls in the Third World.—Flying under the radar, however, is the partnership between The Gates Foundation and drug giant, Pfizer, and therein lies the dirty little secret.-The method of choice to prevent births? Injectable Depo-Provera, long known as a highly dangerous drug. It actually carries a black-box warning on its label, stating that severe bone loss is a consequence of its use. It also thins the vaginal lining, and research is ongoing to investigate the possibility that it increases the risk of breast cancer.–Here is the relevant black-box quote: “Women who use Depro-Provera Contraceptive Injection may lose significant bone mineral density. Bone loss is greater with increased duration of use and may not be completely reversible.” –Change.org and several other groups are petitioning the US Congress to cut all federal funding for Depo-Provera. Despite cheerful PR about education of women on the benefits of contraception, and the need for informed consent, these programs have a way of turning into something else out in the field, where the needle meets the body.–Depo-Provera also happens to be a drug of choice for the “chemical castration” of male sex offenders. That fact testifies to its powerful impact on the body.—Nobody at the London Family Planning Summit was talking about Depo-Provera and its severe effects. The conference sponsors, the UN Population Fund, the USAID, and The Gates Foundation, are far more interested in population control.—If millions of girls and women in Africa and South Asia are crippled by the Depo-Provera injections, well, that’s just collateral damage. Several years from now, we’ll no doubt see studies claiming an unexplained epidemic of osteoporosis in the Third World, which will lead to the application of some other highly toxic drug as the treatment of choice.–Pfizer, the maker of Depo-Provera, happens to make such a drug: Fablyn (Lasofoxifene). So far, the FDA has withheld approval, but the EU gave it the green light in 2009. Fablyn has a serious problem. It causes blood clots in veins, which can be life-threatening.—-Watch out, Africa. Melinda’s coming with Pfizer. You should ask her why she doesn’t supply money to clean up contaminated water supplies, install rudimentary sanitation, provide real nutrition, and help restore stolen fertile land to local farmers.—But you see, those actions aren’t in line with the elite agenda. They make things better. The agenda is dedicated to Worse.
Composition- efficacy and safety of spinach extracts.
Lomnitski L, Bergman M, Nyska A, Ben-Shaul V, Grossman S.
Source–Bar-Ilan University, Ramat-Gan, Israel.
Abstract–Spinach leaves, containing several active components, including flavonoids, exhibit antioxidative, antiproliferative, and antiinflammatory properties in biological systems. Spinach extracts have been demonstrated to exert numerous beneficial effects, such as chemo- and central nervous system protection and anticancer and antiaging functions. In this review article, we present a compilation of data generated in our laboratories and those of other investigators describing the chemical composition of spinach, its beneficial effects, relative safety information, and its recommended inclusion in the human diet. A powerful, water-soluble, [U2]natural antioxidant mixture (NAO), which specifically inhibits the lipoxygenase enzyme, was isolated from spinach leaves. The antioxidative activity of NAO has been compared to that of other known antioxidants and found to be superior in vitro and in vivo to that of green tea, N-acetylcysteine (NAC), butylated hydroxytoluene (BHT), and vitamin E. NAO has been tested for safety and is well tolerated in several species, such as mouse, rat, and rabbit. NAO has been found to be nonmutagenic and has shown promising anticarcinogenic effects in a few experimental models, such as skin and prostate cancer; it has not shown any target-organ toxicity or side effects. The current review provides epidemiological and preclinical data supporting the efficacy of extracts of spinach and the safety of its consumption.-PMID-14690799 -[PubMed – indexed for MEDLINE]
Pressurized liquid extraction of flavonoids from spinach.
Howard L, Pandjaitan N.
Source–Department of Food Science, University of Arkansas, 2650 N. Young Ave., Fayetteville, AR 72704, USA. [email protected]
Abstract—Pressurized liquid extraction (PLE) using water and a 70:30 mixture of ethanol and water over the temperature range of 5[U3]0 to 190 degrees C was used to extract flavonoids from dried spinach. The total phenolic content, antioxidant capacity, color, and browning indices of the extracts were also evaluated. PLE using a 70:30 mixture of ethanol and water was more effective than water in extracting flavonoids from[U4] spinach. Flavonoids were effectively extracted over the temperature band of 50 to 130 degrees C with water and 50 to 150 degrees C with ethanolic solvent. Levels of total phenolics and ORAC values increased with increasing extraction temperature, indicating that flavonoids were minor contributors to antioxidant capacity at elevated extraction temperatures. Browning of ethanolic extracts correlated highly with ORAC values over the temperature range of 50 to 190 degrees C, and the ORAC values of the large molecular weight fraction (> 1000 Da) increased linearly over the temperature range, indicating that Maillard polymers were the major contributors to antioxidant capacity. The results illustrate that PLE temperatures of < 130 degrees C for water or < 150 degrees C for ethanolic solvent may be used to extract flavonoids, followed by a high temperature (> 170 degrees C) extraction to generate antioxidant-rich moieties.[U5]
Recipe-Measure out some spinach—3 oz then take about 10 oz of fluid( 70 % vodka or clear based ethanol that is drinkable and 30 percent reverse osmosis or distilled water ) add them to a blender or a bottle blender—and proceed to blend this —if you have a thermometer you can tap it to the side of the blender to see the heat—when it reaches 120 degrees fahr or 50 cel the you can let it extract for about 5 minutes—turn of blender and strain the material—you will have made this spinach extract
Vitamin E May Lower Liver Cancer Risk
ScienceDaily (July 17, 2012) — High consumption of vitamin E either from diet or vitamin supplements may lower the risk of liver cancer, according to a study published July 17 in the Journal of the National Cancer Institute.—Liver cancer is the third most common cause of cancer mortality in the world, the fifth most common cancer found in men and the seventh most common in women. Approximately 85% of liver cancers occur in developing nations, with 54% in China alone. Some epidemiological studies have been done to examine the relationship between vitamin E intake and liver cancer; however, the results have been inconsistent.—To determine the relationship between vitamin E intake and liver cancer risk, Wei Zhang, MD, MPH., of the Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine and colleagues analyzed data from a total of 132,837 individuals in China who were enrolled in the Shanghai Women’s Health Study (SWHS) from 1997-2000 or the Shanghai Men’s Health Study (SMHS) from 2002-2006, two population-based cohort studies jointly conducted by the Shanghai Cancer Institute and Vanderbilt University. Using validated food-frequency questionnaires, the researchers conducted in-person interviews to gather data on study participants’ dietary habits. They compared liver cancer risk among participants who had high intake of vitamin E with those with low intake.—The analysis included 267 liver cancer patients (118 women and 149 men) who were diagnosed between 2 years after study enrollment and an average of 10.9 (SWHS) or 5.5 (SMHS) years of follow-up. Vitamin E intake from diet and vitamin E supplement use were both associated with a lower risk of liver cancer. This association was consistent among participants with and without self-reported liver disease or a family history of liver cancer. “We found a clear, inverse dose-response relation between vitamin E intake and liver cancer risk,” the authors write, noting a small difference between men and women in the risk estimate, which is likely attributable to fewer liver cancer cases having occurred among SMHS participants due to the shorter follow-up period. Overall, the take home message is that, “high intake of vitamin E either from diet or supplements was related to lower risk of liver cancer in middle-aged or older people from China.”—Story Source-The above story is reprinted from materials provided by Journal of the National Cancer Institute, via EurekAlert!, a service of
[U1]We can utilize other things that are herbal or supplemental or even armoatherapeutic to achieve this
[U2]Water soluble==Tea or extracting the spinach at a high velocity extractor ( juice macjhine or blender or extruder )
[U3]Here we go we are using temperatures at 50 cel ( 120 degress fahr ) 190 degree cel ( 374 degrees fahr)-using water and a 70:30 mixture of ( ethanol=vodka gin-brandy-whisky etc ) and water ( distilled or reverse osmosis
[U4]So using a mixture of vodka 70 % and water 30 % was more effective then just using water )
[U5]So the hotter it gets the better antioxidant profle with the mixture of alcohol and water and the many different varieties of antioxidants
Show of the Week July 27-2012
Woman Pulls Gun To Prevent Smart Meter Installation
Farm to Market- New Device Makes Cleaning Leafy Greens Easy, Economical
Vaccines Backfire- Veterinary Vaccines Found to Combine Into New Infectious Viruses
Reorganizing Brain Could Lead to Improved Treatments for Stroke, Tinnitus
Evaluation of the antiviral activity of a green tea solution as a hand-wash disinfectant
Woman Pulls Gun To Prevent Smart Meter Installation
Homeowners reject unconstitutional intrusion
A Harris County woman pulled a gun on a CenterPoint Energy worker to prevent the installation of a smart meter in a confrontation that highlights concerns about the devices being used to spy on Americans’ energy use, as well as possible health impacts.—-55-year-old Thelma Taormina has signs posted on her front gate warning utility employees not to trespass on her land, as well as another that reads, “No smart meters are to be installed on this property.”—However, that didn’t stop a CenterPoint Energy worker from attempting to replace Taormina’s old electricity meter with a new device that wirelessly beams back information on each home’s energy use to a central hub.–When the worker began physically pushing Taormina out of the way in an effort to install the smart meter, Taormina drew her gun and demanded the worker leave the property .–[U1]“Our constitution allows us not to have that kind of intrusion on our personal privacy,” Taormina told KHOU 11 News. “They’ll be able to tell if you are running your computer, air conditioner, whatever it is.” –Indeed, privacy experts have warned that smart meters could be used to spy on consumers in a myriad of different ways, including “what appliances are being used in individual homes, and even what programmes are being watched on TV.”—The European Data Protection Supervisor (EDPS) warns that the rollout of smart meters will allow “massive collection of personal data” by utility companies and governments, tracking what “households do within the privacy of their own homes, whether they are away on holiday or at work, if someone uses a specific medical device or a baby monitor, or how they spend their free time”.[U2]–Taormina and her husband also expressed fears about the potential health impacts of the smart meter—The American Academy of Environmental Medicine and other health bodies have voiced concern about potential damaging effects of radio waves emitted by the smart meters and have have urged a moratorium on installing the devices.—The group recently warned that people suffering from “neurological, neurodegenerative diseases, genetic defects, cancer, and other conditions,” should avoid smart meters because they could be “adversely impacted by electromagnetic frequency (EMF) and radiofrequency (RF) fields,” emitted by the devices.[U3]–The Public Utilities Commission is now debating whether to allow homeowners who have already had smart meters installed to have them removed. In other areas of the country, utility companies are forcing residents to pay an extra charge to stay on conventional analogue meters.—CenterPoint Energy is now threatening to take Taormina to court over her actions in forcing the utility worker off her property.
Farm to Market- New Device Makes Cleaning Leafy Greens Easy, Economical
A simple and inexpensive device to wash leafy produce, created by students at the University of Houston Conrad N. Hilton College of Hotel and Restaurant Management (HRM), may provide a convenient way for small farmers to clean produce before market. (Credit: Image courtesy of University of Houston)—ScienceDaily (July 16, 2012) — A simple and inexpensive device to wash leafy produce, created by students at the University of Houston Conrad N. Hilton College of Hotel and Restaurant Management (HRM), may provide a convenient way for small farmers to clean produce before market.—“Leafy greens have the highest incidence of contamination nationwide,” said graduate student Cecilia Zerio Egli. “There is not a lot of research available for smaller farms to access methods for efficiently and economically washing produce before it goes to markets.”—Zerio Egli is studying in the HRM Food Safety Laboratory, directed by Professor Jay Neal. The laboratory performs microbiological and sensory research, while collaborating and publishing with other universities and government agencies. In addition, the lab has a full production kitchen, as well as a sensory evaluation laboratory. In August 2012, the lab will achieve a Bio-Safety Level 2 upgrade, which will enable researchers to work with pathogenic or disease causing microorganisms.—Supported by a grant from the Texas Department of Agriculture, Zerio Egli and Neal surveyed more than 80 local and regional farmers about their harvesting and washing practices, asking if they would use a washing device if it were available. “Small famers” were defined as earning less than $500,000 annually. These farms are exempt from the Food and Drug Administration’s Food Safety Modernization Act, which focuses on preventing food contamination rather than responding to outbreaks.—Unlike large commercial farms that can ship produce to packing facilities that wash the vegetables, smaller farmers must do everything themselves, from harvesting and packaging to transporting to market. Not all produce is washed before heading to market.—“Packing sheds have flumes which are water-wash systems with a chlorinated treatment,” Neal said. “When you buy packaged lettuce that says ‘washed three times’ that’s how it was done. Small famers don’t have that.”-Zerio Egli’s device is made from PVC pipe, a stainless steel strainer and a five-gallon drum. Leafy vegetables placed inside the stainless steel container are spun as they’re showered briefly with water to remove dirt. With the flick of a lever, the container lowers into the plastic drum where it is spun in a vinegar and water solution, proven to best clean produce of any harmful bacteria. Finally, the container is lifted to its original position where the produce is rinsed with water again.—I’ll be making an information sheet which will have the plans for how small farmers can easily build the device themselves and where they can purchase the inexpensive materials,” she said. “And farmers can manipulate the size to fit their individual needs.” The information sheet also will have resources for farmers about best practices when growing, harvesting and washing produce.–Zerio Egli and Neal plan to make the plans available in the fall to farmers and –Story Source-The above story is reprinted from materials provided by University of Houston.
Vaccines Backfire- Veterinary Vaccines Found to Combine Into New Infectious Viruses
Vaccines combine to produce new virus strain. —ScienceDaily (July 12, 2012) — Research from the University of Melbourne has shown that two different vaccine viruses- used simultaneously to control the same condition in chickens- have combined to produce new infectious viruses, prompting early response from Australia’s veterinary medicines regulator.—The vaccines were used to control infectious laryngotracheitis (ILT), an acute respiratory disease occurring in chickens worldwide. ILT can have up to 20% mortality rate in some flocks and has a significant economic and welfare impact in the poultry industry.–The research found that when two different ILT vaccine strains were used in the same populations, they combined into two new strains (a process known as recombination), resulting in disease outbreaks.—Neither the ILT virus or the new strains can be transmitted to humans or other animals, and do not pose a food safety risk.—The study was led by Dr Joanne Devlin, Professor Glenn Browning and Dr Sang-Won Lee and colleagues at the Asia-Pacific Centre for Animal Health at the University of Melbourne and NICTA’s Victoria Research Laboratory and is published July 13, 2012] in the journal Science.–Dr Devlin said the combining of live vaccine virus strains outside of the laboratory was previously thought to be highly unlikely, but this study shows that it is possible and has led to disease outbreaks in poultry flocks.–“We alerted the Australian Pesticide and Veterinary Medicines Authority (APVMA) to our findings and they are now working closely with our research team, vaccine registrants and the poultry industry to determine both short and long term regulatory actions,” she said.—“Short-term measures include risk assessment of all live virus vaccines currently registered by the APVMA in regard to the risk of recombination and could include changes to product labels, which may result in restrictions on the use of two vaccines of different origins in the one animal population.”—The ILT vaccines are ‘live attenuated vaccines’, which means that the virus has some disease-causing factors removed but the immune system still recognises the virus to defend against a real infection.—“Live vaccines are used throughout the world to control ILT in poultry. For over 40 years the vaccines used in Australia were derived from an Australian virus strain. But following a vaccine shortage another vaccine originating from Europe was registered in 2006 and rapidly became widely used,”[U4] Dr Devlin said.—“Shortly after the introduction of the European strain of vaccine, two new strains of ILT virus were found to be responsible for most of the outbreaks of disease in New South Wales and Victoria. So we sought to examine the origin of these two new strains.”—The team sequenced all of the genes (the genome) of the two vaccines used in Australia, and the two new outbreak strains of the virus. Following bioinformatic analysis on the resulting DNA sequence, in conjunction with Dr John Markham at NICTA’s Victoria Research Laboratory, they found that the new disease-causing strains were combinations of the Australian and European origin vaccine strains.—[U5]”Comparisons of the vaccine strains and the new recombinant strains have shown that both the recombinant strains cause more severe disease, or replicate to a higher level than the parent vaccine strains that gave rise to them,” Dr Lee said.—Professor Glenn Browning said recombination was a natural process that can occur when two viruses infect the same cell at the same time.—“While recombination has been recognised as a potential risk associated with live virus vaccines for many years, the likelihood of it happening in viruses like this in the field has been thought to be so low that it was considered to be very unlikely to lead to significant problems,” he said.–“Our studies have shown that the risk of recombination between different vaccine strains in the field is significant as two different recombinant viruses arose within a year. We also demonstrated that the consequences of such recombination can be very severe, as the new viruses have been responsible for the deaths of thousands of Australian poultry.”—“The study suggests that regulation of live attenuated vaccines for all species needs to take into account the real potential for vaccine viruses to combine. Measures such as those now being taken for the ILT vaccines will need to be implemented.”-The above story is reprinted from materials provided by University of Melbourne, via EurekAlert!, a service of AAAS. –Journal Reference-Sang-Won Lee, Philip F. Markham, Mauricio J. C. Coppo, Alistair R. Legione, John F. Markham, Amir H. Noormohammadi, Glenn F. Browning, Nino Ficorilli, Carol A. Hartley, and Joanne M. Devlin. Attenuated Vaccines Can Recombine to Form Virulent Field Viruses. Science, 13 July 2012: 188 DOI: 10.1126/science.1217134
Reorganizing Brain Could Lead to Improved Treatments for Stroke, Tinnitus
ScienceDaily (July 19, 2012) — UT Dallas researchers recently demonstrated how nerve stimulation paired with specific experiences, such as movements or sounds, can reorganize the brain. This technology could lead to new treatments for stroke, tinnitus, autism and other disorders.—In a related paper, UT Dallas neuroscientists showed that they could alter the speed at which the brain works in laboratory animals by pairing stimulation of the vagus nerve with fast or slow sounds.–A team led by Dr. Robert Rennaker and Dr. Michael Kilgard looked at whether repeatedly pairing vagus nerve stimulation with a specific movement would change neural activity within the laboratory rats’ primary motor cortex. To test the hypothesis, they paired the vagus nerve stimulation with movements of the forelimb in two groups of rats. The results were published in a recent issue of Cerebral Cortex.–After five days of stimulation and movement pairing, the researchers examined the brain activity in response to the stimulation. The rats who received the training along with the stimulation displayed large changes in the organization of the brain’s movement control system. The animals receiving identical motor training without stimulation pairing did not exhibit any brain changes, or plasticity.–People who suffer strokes or brain trauma often undergo rehabilitation that includes repeated movement of the affected limb in an effort to regain motor skills. It is believed that repeated use of the affected limb causes reorganization of the brain essential to recovery. The recent study suggests that pairing vagus nerve stimulation with standard therapy may result in more rapid and extensive reorganization of the brain, offering the potential for speeding and improving recovery following stroke, said Rennaker, associate professor in The University of Texas at Dallas’ School of Behavioral and Brain Sciences—“Our goal is to use the brain’s natural neuromodulatory systems to enhance the effectiveness of standard therapies,” Rennaker said. “Our studies in sensory and motor cortex suggest that the technique has the potential to enhance treatments for neurological conditions ranging from chronic pain to motor disorders. Future studies will investigate its effectiveness in treating cognitive impairments.”—Since vagus nerve stimulation has an excellent safety record in human patients with epilepsy, the technique provides a new method to treat brain conditions in which the timing of brain responses is abnormal, including dyslexia and schizophrenia.—In another paper in the journal Experimental Neurology, Kilgard led a team that paired vagus nerve stimulation with audio tones of varying speeds to alter the rate of activity within the rats’ brains. The team reported that this technique induced neural plasticity within the auditory cortex, which controls hearing.—The UT Dallas researchers are working with a device developed by MicroTransponder, a biotechnology firm affiliated with the University. MicroTransponder currently is testing a vagus nerve stimulation therapy on human patients in Europe in hopes of reducing or eliminating the symptoms of tinnitus, the debilitating disorder often described as “ringing in the ears.”—“Understanding how brain networks self-organize themselves is vitally important to developing new ways to rehabilitate patients diagnosed with autism, dyslexia, stroke, schizophrenia and Alzheimer’s disease,” said Kilgard, a professor of neuroscience.—Treatment of neurological disease is currently limited to pharmacological, surgical or behavioral interventions. But this recent research indicates it may be possible to effectively manipulate the plasticity of the human brain for a variety of purposes[U6]. Patients then could benefit from brain activity intentionally directed toward rebuilding lost skills.–If subsequent studies confirm the UT Dallas findings, human patients may have access to more efficient therapies that are minimally invasive and avoid long-term use of drugs.—Story Source-The above story is reprinted from materials provided by University of Texas at Dallas. –Journal References-Porter BA, Khodaparast N, Fayyaz T, Cheung RJ, Ahmed SS, Vrana WA, Rennaker RL 2nd, Kilgard MP. Repeatedly Pairing Vagus Nerve Stimulation with a Movement Reorganizes Primary Motor Cortex. Cereb Cortex, 2011 Nov 10 [link]—Shetake JA, Engineer ND, Vrana WA, Wolf JT, Kilgard MP. Pairing tone trains with vagus nerve stimulation induces temporal plasticity in auditory cortex. Exp Neurol., 2012 Jan [link]
Evaluation of the antiviral activity of a green tea solution as a hand-wash disinfectant.
Biosci Biotechnol Biochem. 2012;76(3):581-4–Authors: Shin WJ, Kim YK, Lee KH, Seong BL
Abstract–Based on the broad-spectrum antiviral effect of green tea catechins, we established an experimental skin contact model for influenza virus transmission and evaluated the use of a green tea solution as a first-hand disinfectant. The infectivity of the virus on the skin cell layer became obsolete when washed with the green tea solution. The skin contact model could be applied to develop non-pharmaceutical intervention measures for reducing human transmission of the influenza virus.
Recipe—take green tea and extract it in a alcohol material( vodka-grapp-gin-etc) Put in you blender and extract the green tea by blending the 2 for 10 minutes—utilize a 2:1 ratio of alcohol to the green tea( you can go one to one if you choose or any level you deem fit) if you wish to add water with the alcohol then ad 1 part to the 2 parts of alcohol—once blended for the time frame then strain and filter out the material and added to a castile soap and you have made yourself a antiviral solution with green tea
[U1]Here is a woman I admire—she has some brass tacks and stood her ground—now I am wondering if more will follow !!!
[U2]This can allow for unlawful entry by the police or anyone working on staff can now have access to this information and while you’re a way on a holiday or vacation they can break in your place and rob you blind
[U3]Unsafe Monitoring devises that further destroy your health and further debilitate you
[U6]This is a bit of an alarming statement here—what if I take the frequency of these sounds and placed them in a audio device and hit those notes or sounds could this re wire the brain in another way??since this is a programming device –what os to stop this from becoming a rewiring a bit of hardware –our brains?
Show of the Week July 30 2012
Powerful Class of Antioxidants May Be Potent Parkinson’s Treatment
Smart Meters- Correcting the Gross Misinformation
How Malnutrition Leads to Inflamed Intestines
Chemical compound: Common Name (Latin Name)
20-hydroxyecdysone: maral root (Rhaponticum carthamoides)
araloside: spikenard (Aralia mandshurica)
astragaloside: huang qi (Astragalus membranaceus)
bacoside: brahmi (Bacopa monniera)
cucurbitacin: bryonia (Bryonia alba)
eleutheroside: Siberian ginseng (Eleutherococcus senticosus)
ginsenoside: ginseng (Panax ginseng)
gymnemic acid: gurmar (Gymnema sylvestre)
gypenoside: jiaogulan (Gynostemma pentaphyllum)
tanshenoside: bellflower (Codonopsis pilosula)
tinosporoside: guruchi (Tinospora cordifolia)
withanolide: ashwagandha (Withania somnifera)
Powerful Class of Antioxidants May Be Potent Parkinson’s Treatment
ScienceDaily (July 23, 2012) — A new and powerful class of antioxidants could one day be a potent treatment for Parkinson’s disease, researchers report.–A class of antioxidants called synthetic triterpenoids blocked development of Parkinson’s in an animal model that develops the disease in a handful of days, said Dr. Bobby Thomas, neuroscientist at the Medical College of Georgia at Georgia Health Sciences University and corresponding author of the study in the journal Antioxidants & Redox Signaling.—Thomas and his colleagues were able to block the death of dopamine-producing brain cells that occurs in Parkinson’s by using the drugs to bolster Nrf2, a natural antioxidant and inflammation fighter.—–Stressors from head trauma to insecticide exposure to simple aging increase oxidative stress and the body responds with inflammation, part of its natural repair process. “This creates an environment in your brain that is not conducive for normal function,” Thomas said. “You can see the signs of oxidative damage in the brain long before the neurons actually degenerate in Parkinson’s.”–Nrf2, the master regulator of oxidative stress and inflammation, is — inexplicably — significantly decreased early in Parkinson’s. In fact, Nrf2 activity declines normally with age.–“In Parkinson’s patients you can clearly see a significant overload of oxidative stress, which is why we chose this target,” Thomas said. “We used drugs to selectively activate Nrf2.”–They parsed a number of antioxidants already under study for a wide range of diseases from kidney failure to heart disease and diabetes, and found triterpenoids the most effective on Nrf2. Co-author Dr. Michael Sporn, Professor of Pharmacology, Toxicology and Medicine at Dartmouth Medical School, chemically modified the agents so they could permeate the protective blood-brain barrier.—Both in human neuroblastoma and mouse brain cells they were able to document an increase in Nrf2 in response to the synthetic triterpenoids. Human dopaminergic cells are not available for research so the scientists used the human neuroblastoma cells, which are actually cancer cells that have some properties similar to neurons.–Their preliminary evidence indicates the synthetic triterpenoids also increase Nrf2 activity in astrocytes, a brain cell type which nourishes neurons and hauls off some of their garbage. The drugs didn’t protect brain cells in an animal where the Nrf2 gene was deleted, more proof that that Nrf2 is the drugs’ target.–The researchers used the powerful neurotoxin MPTP to mimic Parkinson’s-like brain cell damage in a matter of days. They are now looking at the impact of synthetic triterpenoids in an animal model genetically programmed to acquire the disease more slowly, as humans do. Collaborators at Johns Hopkins School of Medicine also will be providing induced pluripotent stem cells, adult stem cells that can be coaxed into forming dopaminergic neurons, for additional drug testing.—Other collaborators include scientists at Weill Medical College of Cornell University, Johns Hopkins School of Public Health, Moscow State University, Tohoku University and the University of Pittsburgh.–Story Source-The above story is reprinted from materials provided by Georgia Health Sciences University. –Journal Reference-Navneet Ammal Kaidery, Rebecca Banerjee, Lichuan Yang, Natalya A Smirnova, Dmitry M Hushpulian, Karen T Liby, Charlotte W Williams, Masayuki Yamamoto, Thomas W. Kensler, RAJIV RATAN, Michael B Sporn, Flint Beal, Irina G Gazaryan, Bobby Thomas. Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP- mouse model of Parkinson’s disease. Antioxidants & Redox Signaling, 2012; : 120701083204005 DOI: 10.1089/ars.2011.4491
Smart Meters- Correcting the Gross Misinformation
Quebec-based magazine La Maison du 21e siecle asked physician David O. Carpenter, former founding dean of the University at Albany (NY)’s School of Public Health, to comment on a letter published in the Montreal daily Le Devoir last May 24. This letter claimed wireless smart meters pose no risk to public health. Some fourty international experts contributed to the following rebuttal.
We, the undersigned are a group of scientists and health professionals who together have coauthored hundreds of peer-reviewed studies on the health effects of electromagnetic fields (EMFs). We wish to correct some of the gross misinformation found in the letter regarding wireless “smart” meters that was published in the Montreal daily Le Devoir on May 24. Submitted by a group Quebec engineers, physicists and chemists, the letter in question reflects an obvious lack of understanding of the science behind the health impacts of the radio frequency (RF)/microwave EMFs emitted by these meters.—The statement that « Thousands of studies, both epidemiological and experimental in humans, show no increase in cancer cases as a result of exposure to radio waves of low intensity… » is false (1). In fact, only a few such studies — two dozen case-control studies of mobile phone use, certainly not thousands, have reported no elevations of cancer, and most were funded by the wireless industry. In addition, these reassuring studies contained significant experimental design flaws, mainly the fact that the populations followed were too small and were followed for a too short period of time.—Non industry-funded studies have clearly demonstrated a significant increase in cancer cases among individuals who have suffered from prolonged exposure to low-level microwaves, transmitted notably by radio antennas. The effects were best documented in meta-analyses that have been published and that include grouped results from several different studies: these analyses consistently showed an increased risk of brain cancer among regular users of a cell phone who have been exposed to microwaves for at least ten years.
Brain Cancer Rates——-Furthermore, the argument that brain cancer rates do not indicate an overall increase in incidence is not evidence that cell phones are safe: the latency for brain cancer in adults after environmental exposure can be long, up to 20-30 years. Most North Americans haven’t used cell phones extensively for that long. The evidence of the link between long-term cell phone use and brain cancer comes primarily from Northern Europe, where cell phones have been commonly used since the 1990s.——–Children are especially at risk. In May 2012, the U.K.’s Office of National Statistics reported a 50 percent increase in incidence of frontal and temporal lobe tumors in children between 1999 and 2009. This statistic is especially disturbing since in May 2011, after reviewing the published scientific literature regarding cancers affecting cell phone users, the International Agency for Research on Cancer (IARC) classified radiofrequency radiation as a 2B, possible human carcinogen. Despite the absence of scientific consensus, the evidence is sufficiently compelling for any cautious parent to want to reduce their loved one’s exposure to RF/microwave emissions as much as possible, as recommended by various countries such as Austria, Belgium, Germany,Russia and the United Kingdom.
Electrosensitivity—Public fears about wireless smart meters are well-founded. They are backed by various medical authorities such as those of the Santa Cruz County(California) Public Health Department. These authorities are worried about the growing number of citizens who say they have developed electro hypersensitivity (EHS), especially since for many of them, the symptoms developed after the installation of such meters (it takes some time for most people to link the two events).–Since the turn of the millennium, people are increasingly affected by ambient microwaves due to the growing popularity of wireless devices such as cell phones and Wi-Fi Internet. Therefore, the mass deployment of smart grids could expose large chunks of the general population to alarming risk scenarios without their consent. According to seven surveys done in six European countries between 2002 and 2004, about 10% of Europeans have become electrosensitive, and experts fear that percentage could reach 50% by 2017. The most famous person to publicly reveal her electrosensitivity is Gro Harlem Brundtland, formerly Prime Minister of Norway and retired Director of the World Health Organization (WHO).—-While there is no consensus on the origins and mechanisms of EHS, many physicians and other specialists around the world have become aware that EHS symptoms (neurological dermatological, acoustical, etc.) seem to be triggered by exposure to EMF levels well below current international exposure limits, which are established solely on short-term thermal effects (2). Organizations such as the Austrian Medical Associationand the American Academy of Environmental Medicine have recognized that the ideal way to treat of EHS is to reduce EMF exposure.——–Therefore, caution is warranted because the growing variety of RF/microwave emissions produced by many wireless devices such as smart meters have never been tested for their potential biological effects.
While the specific pathways to cancer are not fully understood, it is scientifically unacceptable to deny the weight of the evidence regarding the increase in cancer cases in humans that are exposed to high levels of RF/microwave radiation.—The statement that « there is no established mechanism by which a radio wave could induce an adverse effect on human tissue other than by heating » is incorrect, and reflects a lack of awareness and understanding of the scientific literature on the subject. In fact, more than a thousand studies done on low intensity, high frequency, non-ionizing radiation, going back at least fifty years, show that some biological mechanisms of effect do not involve heat. This radiation sends signals to living tissue that stimulate biochemical changes, which can generate various symptoms and may lead to diseases such as cancer.—-Even though RF/microwaves don’t have the energy to directly break chemical bonds, unlike ionizing radiation such as X-rays, there is scientific evidence that this energy can cause DNA damage indirectly leading to cancer by a combination of biological effects[U1]. Recent publications have documented the generation of free radicals, increased permeability of the blood brain barrier allowing potentially toxic chemicals to enter the brain, induction of genes, as well as altered electrical and metabolic activity in human brains upon application of cell phone RF/microwaves similar to those produced by smart meters.—These effects are cumulative and depend on many factors including RF/microwave levels, frequency, waveform, exposure time, biovariability between individuals and combination with other toxic agents[U2]. Clear evidence that these microwaves are indeed bioactive has been shown by the fact that low-intensity EMFs have proven clinically useful in some circumstances. Pulsed EMFs have long been used to successfully treat bone fractures that are resistant to other forms of therapy. More recently, frequency-specific, amplitude-modulated EMFs have been found useful to treat advanced carcinoma and chronic pain.—-High frequency EMFs such as the microwaves used in cell phones, smart meters, Wi-Fi and cordless ‘‘DECT’’ phones, appear to be the most damaging when used commonly. Most of their biological effects, including symptoms of electrohypersensitivity, can be seen in the damage done to cellular membranes by the loss of structurally-important calcium ions. Prolonged exposure to these high frequencies may eventually lead to cellular malfunction and death.—-Furthermore, malfunction of the parathyroid gland, located in the neck just inches from where one holds a cell phone, may actually cause electrohypersensitivity in some people by reducing the background level of calcium ions in the blood. RF/microwave radiation is also known to decrease the production of melatonin, which protects against cancer, and to promote the growth of existing cancer cells.
Early warning scientists attacked—-In recommending that the Precautionary Principle be applied in EMF matters, the European Environment Agency’s Director Jacqueline McGlade wrote in 2009: “We have noted from previous health hazard histories such as that of lead in petrol, and methyl mercury, that ‘early warning’ scientists frequently suffer from discrimination, from loss of research funds, and from unduly personal attacks on their scientific integrity. It would be surprising if this is not already a feature of the present EMF controversy… » Such unfortunate consequences have indeed occurred.—The statement in the Le Devoir letter that « if we consider that a debate should take place, it should focus exclusively on the effects of cell phones on health » is basically an acknowledgement that there is at least some reason to be concerned about cell phones. However, while the immediate exposure from a cell phone is of much greater intensity than the exposure from smart meters, cell phone use is temporary.
Smart meters—Wireless smart meters typically produce atypical, relatively potent and very short pulsed RF/microwaves whose biological effects have never been fully tested. They emit these millisecond-long RF bursts on average 9,600 times a day with a maximum of 190,000 daily transmissions and a peak level emission two and a half times higher than the stated safety signal, as the California utility Pacific Gas & Electric recognized before that State’s Public Utilities Commission. Thus people in proximity to a smart meter are at risk of significantly greater aggregate exposure than with a cell phone, not to mention the cumulative levels of RF/microwaves that people living near several meters are exposed to.——People are exposed to cell phone microwaves primarily in the head and neck, and only when they use their device. With smart meters, the entire body is exposed to the microwaves, which increases the risk of overexposure to many organs.—In addition to these erratic bursts of modulated microwaves coming from smart meters that are transferring usage data to electric, gas and water utilities, wireless and wired smart (powerline communication) meters are also a major source of ‘’dirty electricity’’ (electrical interference of high frequency voltage transients typically of kilohertz frequencies). Indeed, some scientists, such as American epidemiologist Sam Milham, believe that many of the health complaints about smart meters may also be caused by dirty electricity generated by the « switching » power supply activating all smart meters. Since the installation of filters to reduce dirty electricity circulating on house wiring has been found to relieve symptoms of EHS in some people, this method should be considered among the priorities aimed at reducing potential adverse impacts. Indeed, the Salzburg State (Austria) Public Health Department confirms its concern about the potential public health risk when in coming years almost every electric wire and device will emit such transient electric fields in the kilohertz-range due to wired smart meters.
Rather be safe than sorry—The apparent adverse health effects noted with smart meter exposure are likely to be further exacerbated if smart appliances that use wireless communications become the norm and further increase unwarranted exposure.—To date, there have been few independent studies of the health effects of such sources of more continuous but lower intensity microwaves. However, we know after decades of studies of hazardous chemical substances, that chronic exposure to low concentrations of microwaves can cause equal or even greater harm than an acute exposure to high concentrations of the same microwaves.–This is why so many scientists and medical experts urgently recommend that measures following the Precautionary Principle be applied immediately — such as using wired meters — to reduce biologically inappropriate microwave exposure. We are not advocating the abolishment of RF technologies, only the use of common sense and the development and implementation of best practices in using these technologies in order to reduce exposure and risk of health hazards.
1. Scientific papers on EMF health effects
2. Explanation and studies on electrosensitivity
3. Governments and organizations that ban or warn against wireless technology
• David O. Carpenter, MD, Director, Institute for Health & the Environment, University at Albany, USA
• Jennifer Armstrong, MD, Past President, Canadian Society of Environmental Medicine, Founder, Ottawa Environmental Health Clinic, Ontario, Canada
• Pierre L. Auger, M. D., FRCPC, Occupational medicine, Multiclinique des accidentés 1464, Montreal, Quebec, Canada
• Fiorella Belpoggi, Director Cesare Maltoni Cancer Research Center, Ramazzini Institute, Bologna, Italy
• Martin Blank, PhD, former President, Bioelectromagnetics Society, Special Lecturer, Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, USA
• Barry Breger, MD, Centre d’intégration somatosophique (orthomolecular medicine), Montreal, Quebec
• John Cline, MD, Professor, Institute for Functional Medicine, Federal Way, WA, USA, Medical Director, Cline Medical Centre, Nanaimo, BC, Canada
• Alvaro Augusto de Salles, PhD, Professor of Electrical Engineering, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
• Christos Georgiou, Prof. Biochemistry, Biology Department, University of Patras, Greece
• Andrew Goldsworthy, PhD, Honorary lecturer in Biology, Imperial College, London, UK
• Claudio Gómez-Perretta, MD, PhD, Director, Centro de Investigación, Hospital Universitario LA Fe, Valencia, Spain
• Livio Giuliani, PhD, Senior Researcher, National Insurance Institute (INAIL), Chief of Radiation and Ultrasounds Research Unit, Rome, Italy
• Yury Grigoriev, PhD, Chair Russian National Committee on Non-Ionizing Radiation Protection, Moscow, Russia
• Settimio Grimaldi, PhD, Director, Institute of Translational Pharmacology (Neurobiology and molecular medicine), National Research Council, Rome, Italy
• Magda Havas, PhD, Centre for Health Studies, Trent University, Canada
• Lennart Hardell, MD, Professor of Oncology, University Hospital, Örebro, Sweden
• Denis L. Henshaw, PhD, Professor of Physics, Head of The Human Radiation Effects Group, University of Bristol, UK
• Ronald B. Herberman, MD, Chairman of Board, Environmental Health Trust, and Founding Director emeritus, University of Pittsburgh Cancer Institute, USA
• Isaac Jamieson, PhD Environmental Science (electromagnetic phenomena in the built environment), independent architect, scientist and environmental consultant, Hertfordshire, UK
• Olle Johansson, PhD, Professor of Neuroscience (Experimental Dermatology Unit), Karolinska Institute, Stockholm, Sweden
• Yury Kronn, PhD, Soviet authority on physics of nonlinear vibrations and high frequency electromagnetic vibrations, founder of Energy Tools International, Oregon, USA
• Henry Lai, PhD, Professor of Bioengineering, University of Washington School of Medicine, Seattle, WA, USA
• Abraham R. Liboff, PhD, Professor Emeritus, Department of Physics, Oakland University, Rochester, Michigan, USA
• Don Maisch, PhD, Researcher on radiation exposure standards for telecommunications frequency, EMFacts Consultancy, Tasmania, Australia
• Andrew A. Marino, MD, PhD, JD, Professor of Neurology, LSU Health Sciences Center, Shreveport, LA, USA
• Karl Maret, MD, M.Eng., President, Dove Health Alliance, Aptos, CA, USA
• Sam Milham, MD, former chief epidemiologist, Washington State Department of Health, USA
• Joel M. Moskowitz, PhD, Director, Center for Family and Community Health, School of Public Health, University of California, Berkeley
• Gerd Oberfeld, MD, Public Health Department, Salzburg State Government, Austria
• Jerry L. Phillips, PhD, Director, Center for Excellence in Science, Department of Chemistry and Biochemistry, University of Colorado, USA
• John Podd, PhD, Professor of Psychology (experimental neuropsychology), Massey University, New-Zeland
• William J. Rea, MD, thoracic and cardiovascular surgeon, founder of the Environmental Health Center, Dallas, Tx, USA
• Elihu D. Richter, MD, Professor, Hebrew University-Hadassah School of Public Health and Community Medicine, Jerusalem, Israel
• Leif G. Salford, MD, Senior Professor of Neurosurgery, Lund University, Sweden
• Nesrin Seyhan, MD, Founder and Chair of Biophysics, Medical Faculty of Gazi University, Turkey
• Cyril W. Smith, PhD, lead author of “Electromagnetic Man”, retired from Electronic and Electrical Engineering, University of Salford, UK
• Morando Soffritti, MD, Scientific Director of the European Foundation for Oncology and Environmental Sciences “B. Ramazzini” in Bologna, Italy
• Antoinette “Toni” Stein, PhD, Collaborative on Health and the Environment (CHE-EMF Working Group), Co-Coordinator, Berkeley, CA, USA
• Stanislaw Szmigielski, MD, PhD Professor of Pathophysiology, Consulting Expert, former director of Microwave Safety, Military Institute of Hygiene and Epidemiology, Warsaw, Poland
• Bradford S. Weeks, MD, Director, The Weeks Clinic, Clinton, WA, USA
• Stelios A. Zinelis, MD, Vice-President, Hellenic Cancer Society, Cefallonia, Greece
How Malnutrition Leads to Inflamed Intestines
Malnutrition–ScienceDaily (July 24, 2012) — More than one billion people in poor countries are starving, and malnutrition remains a major problem even in rich countries, making it a leading cause of death in the world. For over a hundred years, doctors have known that a lack of protein in the diet or low levels of amino acids, the building blocks of proteins, can lead to symptoms like diarrhoea, inflamed intestines and other immune system disorders, which weaken the body and can be fatal. However, the molecular mechanism which explains how malnutrition causes such severe symptoms has been largely unexplored.–Now a research group led by Josef Penninger, the director of the Institute of Molecular Biotechnology (IMBA) in Vienna, Austria, in cooperation with Philip Rosenstiel, University of Kiel, Germany, has found a molecular explanation for the increased susceptibility to intestinal inflammation in malnutrition. The researchers were studying an enzyme which helps to control blood pressure, kidney failure in diabetes, heart failure and lung injury, called the Angiotensin Converting Enzyme 2, or ACE2. This enzyme was identified as the key receptor for SARS virus infections, but the researchers also discovered an entirely new function. ACE2 controls the way our intestines take in amino acids from our food, via amino acid transporters, and in particular the uptake of the essential amino acid tryptophan.—-Too little tryptophan alters our natural immune system, which changes the types of bacteria which can live in our bowels and guts, leading to higher sensitivity and eventually diarrhoea and inflamed intestines. Increasing the intake of tryptophan in their diet provided relief for mice suffering from intestinal inflammation. The mixture of bacteria returned to normal, the inflammation died down, and the mice also became less susceptible to new attacks.–“The research shows how the food we eat can directly change the good bacteria in our intestines to bad bacteria and so influence our health”, says Thomas Perlot, the first author of the study. “Our results might also explain nutritional effects that have been known for centuries and provide a molecular link between malnutrition and the bacteria living in our intestines. This discovery could be used in the future to treat patients with a simple regulated diet or by taking tryptophan as a food supplement. And there is hardly any risk of side effects from artificially increasing an amino acid found in the normal diet.”—Josef Penninger, the lead author, says “I have studied ACE2 for more than 10 years and was completely stunned by this novel link between ACE2 and amino acid balance in the gut. Biology continues to surprise me. Up to a billion people in the world are malnourished, especially the poor and disadvantaged. In Austria alone, around 80,000 people suffer from a chronic inflammatory bowel disease like ulcerative colitis or Crohn’s disease. I hope that our findings have opened a door to a better molecular understanding how malnutrition affects human health. Whether simple tryptophan diets can indeed cure the effects of malnutrition in humans now needs to be carefully tested in clinical trials.”
Story Source-The above story is reprinted from materials provided by Institute of Molecular Biotechnology, via AlphaGalileo.
Journal Reference-Tatsuo Hashimoto, Thomas Perlot, Ateequr Rehman, Jean Trichereau, Hiroaki Ishiguro, Magdalena Paolino, Verena Sigl, Toshikatsu Hanada, Reiko Hanada, Simone Lipinski, Birgit Wild, Simone M. R. Camargo, Dustin Singer, Andreas Richter, Keiji Kuba, Akiyoshi Fukamizu, Stefan Schreiber, Hans Clevers, Francois Verrey, Philip Rosenstiel, Josef M. Penninger. ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature, 2012; 487 (7408): 477 DOI: 10.1038/nature11228
[U1]A combination of Bio effects—lets just say Chemtrail Particulates loaded with 23 components—then add mercury leaking lights from cfl’s and what do you have—a combination of radiation and metals toxic to human life
[U2]Again between Individual and combination of toxic agents—this is a wholesale set up to sell us technology to increase a causative effect on deblaitating people and inflctions of radiation and metal poisonings that can effect the brain