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Show of the Month April 19 2014
Fried Fat Cooking
Parasites in humans influence each other via shared food sources
Anti-anxiety drugs, sleeping pills linked to risk of death-Natural or Supplemental Methods For Sleep and AntiAnxiety
Potassium Ascorbate– Scientifically shown homeostatic benefits ascorbate promotes or enhances
Researchers identify how zinc regulates key enzyme involved in cell death–
How zinc starves lethal bacteria to stop infection- Zinc discovery may shed light on Parkinson’s, Alzheimer’s–
Herbs and Foods with good levels of Accessible Zinc
Fried Fat Cooking
There are problems with deep fat fried food that affect our nutrition. These problems occur because of chemical alterations in the fat that happen as a consequence of deep fat frying food.
This frying process is as follows:
1. Food picks up oxygen from the air during frying that negatively alters the fat composition.
2. The foods fried in these fats pick up those altered fats.
3. These altered foods have a direct and negative influence on the nutritional value of the fat.
The changes in the fat are dependent on at least four factors:
1. The length of time it was exposed to heat—in commercial operations, the length of time a food is fried leads to how much fat is absorbed on the “cooked” food item; [F1]
2. The temperature of the fat; [F2]
3. The exact composition of the fat used, such as corn oil, cottonseed oil, soybean oil, beef tallow, or hydrogenated fat, and [F3]
4. What is being fried, e.g., chicken or fish.
The longer the frying fat is heated, the greater the changes in that fat. Feeding animals fats fried at varying lengths of time led to very different outcomes in the health of those animals.–Those animals fed the fats fried the shortest period of time were healthier than those fed the fats fried for the longest times. Those fed fats heated at higher temperatures were not as healthy as those fed on fat heated to lower temperatures.–Also it was interesting that animals fed on heated margarine did not grow as well as those on fresh margarine and that their plasma cholesterol level increased[F4]. Those fed on heated butter oil grew as well as those on fresh butter oil.–Oil from commercial fat fryers was used in a set of experiments that clearly showed that poor nutrition resulted. This is important because used fat from commercial operations is typically collected and fed to animals, such as pigs, to provide energy for rapid growth. –When we conducted experiments feeding the commercially used fat for frying to rats, they did not do well. When we added protein to their diets, the effect of the “bad” heated fat was countered because the added protein provided more adequate nutrition. [F5]–We tried to fortify the diets with adequate vitamins, but that could not counter the growth-depressing effect of the heated oil. A few vitamins, such as riboflavin, helped a bit.–Fish already contain high amounts of polyunsaturated fat that are not present in the fat of chicken or beef. Thus, when fish are fried, the polyunsaturated fat in them can leak into the frying fat causing the fat to be changed more radically into a less healthy version. Chicken and hamburger have less of this polyunsaturated fat and thus are healthier choices to fry.
Eating excessive amounts of fried food also slows down digestion. People may get stomachaches as a result. As early as 1946, a link was shown between heated fats and cancer. What we don’t know yet is whether heated fats by themselves lead to cancer or whether the heated fat combined with specific foods cause cancer.–Animals fed heated fat combined with a known carcinogen developed cancer, whereas those fed fresh fat combined with a known carcinogen, did not. Thus the heated fat was a co-carcinogen.–Commercial frying of food has increased worldwide since our studies on heated fats. In Germany, fat fryers are required by law to test their frying fat for its freshness by a method approved by the German government. In the U.S. a test is also available but its use is not mandatory.[F6]
Free Radicals
Free radicals are produced from oxidized linoleic (n-6) and linolenic acid (n-3); they are fragments of unsaturated fatty acids. This is especially likely to happen when the essential fatty acids are heated, especially the n-3 variety. All oils change structures when they are heated, but those high in n-3 fatty acids have more problems than those high in n-6.-Free radicals provide another reason to avoid fried food. The first sign of fat becoming free radicals is that they are rancid, and they begin to smell “off” and their taste becomes bitter. –Roasted peanuts, for example, can become rancid and then shouldn’t be eaten. Free radicals are “bad” since they destroy vitamins A, D, C, and E, thus preventing these vitamins from doing positive things in the body. –Free radicals also destroy both the essential fatty acids and the essential amino acids. They oxidize the LDL into something called oxidized low density lipoproteins (oxLDL). These oxLDL are very powerful components in the blood that have been considered since about 1990 as involved in the development of heart disease. -The best way to avoid free radicals is simply not eating fried food nor any foods with oil that smells “off.”
Parasites in humans influence each other via shared food sources
March 12, 2014
University of Zurich
Over 1,400 species of parasites — viruses, bacteria, fungi, intestinal worms and protozoa — are able to infect humans. In most cases, the right medicine against a parasite cures the patient. If he or she suffers from an infection by two or more species of parasite at the same time, however, it soon becomes more difficult to diagnose and treat. Medication can even exacerbate the medical condition if one pathogen is killed off but the second flourishes. One reason is the little-understood interactions between the parasites that reside in the same host.[F7]–In a study published in Proceedings of Royal Society B, an international team of researchers including Professor Owen Petchey from the Institute of Evolutionary Biology and Environmental Studies at the University of Zurich presents a network that explains how different pathogens and parasite groups mutually influence each other in the human body. Surprisingly, the biologists discovered that the parasites are most likely to interact via the food source they share — not the immune response or directly through contact with other parasites.
Complex overview with clear patterns—Co-infections are very common: Simultaneous infestations by different intestinal worms, for instance, affect around 800 million people worldwide. In order to develop effective treatment approaches for co-infections, says Owen Petchey, we need to understand the structures of the parasite communities in a host — in this case individual humans — and the interactions between the parasites better. The ecologists from Zurich, Liverpool, Sheffield and Edinburgh compiled a list of 305 parasite species, 124 resources in the host and 98 immune system components in a meta-study — then analyzed over 2,900 combinations of all these factors in an unprecedented manner.
The network displays clear patterns: The infected part of the body and the same food resource are the most common contact points that can lead to an interaction between the different parasites. “We found twice as many parasites fighting for the same energy source as parasites that elicit the same immune response and are able to interact in that way,” explains Petchey. The manner in which the immune system responds to the individual pathogens seems to be of secondary importance, despite the fact that other studies pointed towards precisely this. The direct influence from one parasite to the next is also rarer, with the exception of HIV, Staphilococcus aureus and the Hepatitis C virus, which are known to interact directly with other pathogens.
Personalized medicine in the spotlight
The network-like overview of the various interactions of parasites that can harm humans goes beyond the usual consideration of parasite pairs. “These results can serve as a basis for the development of new, personalized treatment schemes for infected patients,” Petchey hopes. The biologist is currently testing his hypotheses of this synthesis study with different organisms.
Story Source-The above story is based on materials provided by University of Zurich. Note: Materials may be edited for content and length.—Journal Reference-E. C. Griffiths, A. B. Pedersen, A. Fenton, O. L. Petchey. Analysis of a summary network of co-infection in humans reveals that parasites interact most via shared resources. Proceedings of the Royal Society B: Biological Sciences, 2014; 281 (1782): 20132286 DOI: 10.1098/rspb.2013.2286
Remedy—One Simple way to treat this is to take a turpentine remedy either mixed with honey or oil to remove these past—depending on the severity you may want to start of with a tsp increment and if necessay to go up to a 1 oz intake—there have been reports of tapeworms of huge proportions have exited a persons insides
Anti-anxiety drugs, sleeping pills linked to risk of death
March 31, 2014
University of Warwick
The large study, published in BMJ, shows that several anxiolytic (anti-anxiety) drugs or hypnotic drugs (sleeping pills) are associated with a doubling in the risk of mortality.–Anti-anxiety drugs and sleeping pills have been linked to an increased risk of death, according to new research from the University of Warwick.–The large study, published in BMJ, shows that several anxiolytic (anti-anxiety) drugs or hypnotic drugs (sleeping pills) are associated with a doubling in the risk of mortality. Although these findings are based on routine data and need to be interpreted cautiously, the researchers recommended that a greater understanding of their impact is essential.–Professor Scott Weich, Professor of Psychiatry at the University of Warwick, explained “The key message here is that we really do have to use these drugs more carefully. This builds on a growing body of evidence suggesting that their side effects are significant and dangerous. We have to do everything possible to minimise over reliance on anxiolytics and sleeping pills.”–“That’s not to say that they cannot be effective. But particularly due to their addictive potential we need to make sure that we help patients to spend as little time on them as possible and that we consider other options, such as cognitive behavioural therapy, to help them to overcome anxiety or sleep problems.”–The study accounted, where possible, for other factors such as age, smoking and alcohol use, other prescriptions and socioeconomic status. Crucially, the team controlled for contributing risk factors such as sleep disorders, anxiety disorders and other psychiatric illness in all participants.–34,727 people were tracked for seven and a half years on average from the time that they first received prescriptions for either an anxiolytic or hypnotic drug.–Benzodiazepines were the most commonly prescribed drug class, including diazepam and temazepam. The study also examined the effects of two other groups of drugs; the so-called ‘Z-drugs’ and all other anxiolytic and hypnotic drugs. Many patients received more than one drug over the course of the study, and 5% received prescriptions for drugs from all three groups.-Story Source-The above story is based on materials provided by University of Warwick. Note: Materials may be edited for content and length.-Journal Reference-S. Weich, H. L. Pearce, P. Croft, S. Singh, I. Crome, J. Bashford, M. Frisher. Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study. BMJ, 2014; 348 (mar19 5): g1996 DOI: 10.1136/bmj.g1996
Natural or Supplemental Methods For Sleep and AntiAnxiety
Taurine 500mgs + Inositol 500mgs taken 3-5 times a day
Niacinamide 500mgs + Gaba 500mgs before bed for sleep
Niacinamide 500mgs + Glycine 500 3-5times a day
Trytophan 500 mgs+ Nicainamide 500 mgs before Bed
Melatonin 3 mgs + Nicainamide 500 mgs before bed
Taurine 500mgs + Magnesium Citrate 100mgs+ Potassium Citrate 100mgs-daytime
Taurine 500mgs + Inositol 500mgs—during day
Pregnenolone 10-30 mgs + B5 500—early morning
Iodine 1-2 drops + Tyrosine 500mgs early morning mid day
Chamomile tea + Motherwort equal portions in water as a tea-evening hours
St Johns Wort + Passion flower equal portions in water as a tea-evening Hours
Ginger + Cinnamon Tea –first thing in the morning mid day
Coffee Black + Peppermint leaf –First thing in morning midday
Essential Oils of Rosemary-Lavender-Neroli-Orange-Lemon—just sniffing them or inhaling strongly can relax a person
Cocoa + Vanilla mixed in Honey can have a relaxing effect
Vanilla + Black Pepper mixed in Honey
Potassium Ascorbate
Potassium Ascorbate is a salt derived from Ascorbic Acid (Vitamin C), obtained by making a solution in cold water using two compounds (Ascorbic Acid and Potassium Bicarbonate) in an extremely pure crystalline form (not less than 97% purity). This compound has extremely powerful anti-oxidant properties. Since this salt possesses extraordinary efficacy against degenerative pathologies, its use in regular doses, including at a preventive level, stimulates the body’s immune defenses. It acts by restoring (or maintaining) correct intra-cellular Potassium levels, thus promoting healthy cell metabolism while reversing degenerative processes (if applicable) in that ascorbic acid acts as the Potassium carrier inside the body’s cells and the compound offers protective qualities thanks to its highly anti-oxidant properties.
Potassium ascorbate is a mineral salt of ascorbic acid. It is a non-acidic pH neutral form of Vitamin C that provides the great benefits of Vitamin C without upsetting the stomach and digestive system. Mineral ascorbates are especially helpful for those who do not tolerate regular Vitamin C formulas well. Potassium acorbate delivers a high-potency source of vitamin C in the form of high-bioavailability potassium. Potassium ascorbate offers the potent antioxident protection of Vitamin C along with the health benefits of potassium. It is a natural chelator that binds with minerals and carries the mineral throughout the body. Because of this, mineral ascorbates are easily absorbed and retained by the body.—Potassium Ascorbate would seem to exert an anti-angiogenetic [F8]influence. All cells have an affinity for potassium. Since cancer cells “steal” minerals from healthy cells, cancer cells effectively “steal” potassium ascorbate. In fact, a foundation in Italy has studied the effects that potassium ascorbate can contribute toward potential cancer aid and prevention, helping to defeat and prevent degenerative disease by working on the immune system, making degenerative disease cells essentially “die of hunger”. (Dr Pantellini.–It is worth bearing in mind that since the compound also has a balancing effect on the body’s hormone levels, Potassium Ascorbate may help to increase fertility. It also may have a tendency to regulate blood pressure.
Scientifically shown homeostatic benefits ascorbate promotes or enhances:
* Scurvy resistance: improved blood vessel and cardiovascular integrity
* Enhances hormone healthy and reduces hormone unhealthy actions
* Enhances neurotransmitter functions healthy and reduces unhealthy actions
* Promotes immune system healthy and reduces unhealthy actions
* Enhances nitrous oxide (NO) functions
* Enhances and repairs detoxification functions
* Enhances ATP energy compound production
* Enhances healthy bone formation
* Enhances and rebuilds glutathione functions
* Promotes iron balance [uptake and release]
* Reduces bio-accumulation of toxins
* Improves transit time
* Protects DNA from oxidative damage
* Reduces toxic minerals in body
* Enhances natural anti-cancer surveillance
* Direct tumor cytolytic effects
Scientifically disproven ef fects that as corbate promotes or enhances:
* Immortality
* Fenton reactions in vivo
* B-12 remains active in vivo
* DNA replication error theory not confirmed in vivo
l-Ascorbate: Its scientific significance for human health
Vitamin C (ascorbic acid or l-ascorbate) is nature’s most potent, safer antioxidant cofactor. Ascorbate has gotten a fair amount of attention from the media in the last few years, including whether it is helpful, neutral, or harmful in limiting the number of colds, their symptoms, and their duration.
1. Ascorbate aids in the maintenance of cellular membranes, cellular respiration, the peroxidase cleansing system, the restoration of vitamin E /selenomethionine complexes, and sulfhydryl enzymes such as glutathionesynthetase, thereby helping to detoxify various drugs and chemicals.
2. Ascorbate is also involved in hormone biosynthesis and maintaining the integrity of connective tissue, cartilage, capillaries, bones, and teeth. Vitamin C is , therefore, important in wound repair and tissue healing.
3. Ascorbate has been shown to increase cellular resistance to many common viral infections (most probably due to its interferon-like activity) and enhance specific parameters of immune function.
All of these actions of ascorbate are related to its antioxidant or reducing or electron donating abilities. The use of ascorbate in health and disease is complex and sometimes misunderstood, although much less so when one considers the following facts and supportive background information. While almost all animals and plants synthesize their own vitamin C, exceptions are guinea pigs, monkeys, and humans. The first two of those eat mostly fresh vitamin C-rich foods: fruits and vegetation. Non-human animals, when adjusted for size and weight, make the equivalent of 5 to 15 grams of vitamin C a day, mostly in their livers and when stress free. Production can more than double when the animal is distressed. Our genetic ancestors once had the ability to synthesize vitamin C but appear to have lost it years ago. One enzyme is missing in a 6-enzyme process converting glucose to vitamin C. Scientists estimate that without this mutation, when healthy we would be making 10-30 grams of vitamin C a day throughout our lives and more when we are unwell or distressed
Researchers identify how zinc regulates key enzyme involved in cell death
April 2, 2014
Virginia Commonwealth University
The molecular details of how zinc, an essential trace element of human metabolism, interacts with the enzyme caspase[F9]-3, which is central to apoptosis or cell death, have been elucidated in a new study led by researchers at Virginia Commonwealth University. The study is featured on the cover of the April issue of the journal Angewandte Chemie’s International Edition.–Dysregulation of apoptosis is implicated in cancer and neurodegenerative disease such as Alzheimer’s disease. Zinc is known to affect the process by inhibiting the activity of caspases, which are important drug targets for the treatment of the above conditions. The findings may help researchers design therapeutic agents that target zinc-caspase interaction to specifically control the activity of caspases, and hence, apoptosis.–“The work is unique in helping to open up a broad new area of research which we call the bioinorganic chemistry of apoptosis — understanding the role of essential metal ions in one of life’s fundamental processes,” said corresponding author Nicholas P. Farrell, Ph.D., member of the Developmental Therapeutics program at VCU Massey Cancer Center and professor of chemistry in the VCU College of Humanities and Sciences.–“Indeed, the zinc inhibition of apoptosis in fact contrasts with the role of its closely related neighbor copper, which is understood to enhance apoptosis,” he said.–In the study, Farrell and his research team, A. Gerard Daniel, Ph.D., and Erica J. Peterson, used conventional enzymology and biophysical techniques combined with state-of-the-art computational methods, to show evidence for a hitherto unrecognized interaction site with caspase-3.–According to Farrell, caspases were discovered in the mid-1990s. There are 11 caspases known humans, and seven of these are involved in cell death. The study suggests a regulatory zinc site that may be common to all caspases. Previous findings have shown other zinc binding sites in caspase-6 and -9. Now, Farrell said, the generality of the team’s observations must be extended and verified in other caspases.–“The [journal] cover epitomizes the contrasting but interdependent roles of the metal ions copper/zinc in the regulation of apoptosis and perfectly captures the duality of this most fundamental of biological processes,” Farrell said.–Story Source-The above story is based on materials provided by Virginia Commonwealth University. The original article was written by Sathya Achia Abraham. Note: Materials may be edited for content and length.-Journal Reference-A. Gerard Daniel, Erica J. Peterson, Nicholas P. Farrell. The Bioinorganic Chemistry of Apoptosis: Potential Inhibitory Zinc Binding Sites in Caspase-3. Angewandte Chemie International Edition, 2014; DOI: 10.1002/anie.201401105
How zinc starves lethal bacteria to stop infection
November 11, 2013
University of Adelaide
Australian researchers have found that zinc can ‘starve’ one of the world’s most deadly bacteria by preventing its uptake of an essential metal.–The finding, by infectious disease researchers at the University of Adelaide and The University of Queensland, opens the way for further work to design antibacterial agents in the fight against Streptococcus pneumoniae.–Streptococcus pneumoniae is responsible for more than one million deaths a year, killing children, the elderly and other vulnerable people by causing pneumonia, meningitis, and other serious infectious diseases.–Published today in the journal Nature Chemical Biology, the researchers describe how zinc “jams shut” a protein transporter in the bacteria so that it cannot take up manganese, an essential metal that Streptococcus pneumoniae needs to be able to invade and cause disease in humans.–“It’s long been known that zinc plays an important role in the body’s ability to protect against bacterial infection, but this is the first time anyone has been able to show how zinc actually blocks an essential pathway causing the bacteria to starve,” says project leader Dr Christopher McDevitt, Research Fellow in the University of Adelaide’s Research Centre for Infectious Diseases.–“This work spans fields from chemistry and biochemistry to microbiology and immunology to see, at an atomic level of detail, how this transport protein is responsible for keeping the bacteria alive by scavenging one essential metal (manganese), but at the same time also makes the bacteria vulnerable to being killed by another metal (zinc),” says Professor Bostjan Kobe, Professor of Structural Biology at The University of Queensland.–The study reveals that the bacterial transporter (PsaBCA) uses a ‘spring-hammer’ mechanism to bind the metals. The difference in size between the two metals, manganese and zinc, causes the transporter to bind them in different ways. The smaller size of zinc means that when it binds to the transporter, the mechanism closes too tightly around the zinc, causing an essential spring in the protein to unwind too far, jamming it shut and blocking the transporter from being able to take up manganese.–“Without manganese, these bacteria can easily be cleared by the immune system,” says Dr McDevitt. “For the first time, we understand how these types of transporters function. With this new information we can start to design the next generation of antibacterial agents to target and block these essential transporters.”–Story Source-The above story is based on materials provided by University of Adelaide.-Journal Reference-Rafael M Couñago, Miranda P Ween, Stephanie L Begg, Megha Bajaj, Johannes Zuegg, Megan L O’Mara, Matthew A Cooper, Alastair G McEwan, James C Paton, Bostjan Kobe, Christopher A McDevitt. Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 2013; DOI: 10.1038/nchembio.1382
Zinc discovery may shed light on Parkinson’s, Alzheimer’s
September 30, 2013
University of Wisconsin-Madison
Scientists at the University of Wisconsin-Madison have made a discovery that, if replicated in humans, suggests a shortage of zinc may contribute to diseases like Alzheimer’s and Parkinson’s, which have been linked to defective proteins clumping together in the brain.–With proteins, shape is everything. The correct shape allows some proteins to ferry atoms or molecules about a cell, others to provide essential cellular scaffolding or identify invading bacteria for attack. When proteins lose their shape due to high temperature or chemical damage, they stop working and can clump together — a hallmark of Parkinson’s and Alzheimer’s.–The UW researchers have discovered another stress that decreases protein stability and causes clumping: a shortage of zinc, an essential metal nutrient.–Zinc ions play a key role in creating and holding proteins in the correct shape. In a study just published in the online Journal of Biological Chemistry, Colin MacDiarmid and David Eide show that the gene Tsa1 creates “protein chaperones” that prevent clumping of proteins in cells with a zinc shortage. By holding proteins in solution, Tsa1 prevents damage that can otherwise lead to cell death.–For simplicity, the researchers studied the system in yeast — a single-celled fungus. Yeast can adapt to both shortages and excesses of zinc, says MacDiarmid, an associate scientist. “Zinc is an essential nutrient but if there’s too much, it’s toxic. The issue for the cell is to find enough zinc to grow and support all its functions, while at the same time not accumulating so much that it kills the cell.”–Cells that are low in zinc also produce proteins that counter the resulting stress, including one called Tsa1.–The researchers already knew that Tsa1 could reduce the level of harmful oxidants in cells that are short of zinc. Tsa1, MacDiarmid says, “is really a two-part protein. It can get rid of dangerous reactive oxygen species that damage proteins, but it also has this totally distinct chaperone function that protects proteins from aggregating. We found that the chaperone function was the more important of the two.”–“In yeast, if a cell is deficient in zinc, the proteins can mis-fold, and Tsa1 is needed to keep the proteins intact so they can function,” says Eide, a professor of nutritional science. “If you don’t have zinc, and you don’t have Tsa1, the proteins will glom together into big aggregations that are either toxic by themselves, or toxic because the proteins are not doing what they are supposed to do. Either way, you end up killing the cell.”–While the medical implications remain to be explored, there are clear similarities between yeast and human cells. “Zinc is needed by all cells, all organisms, it’s not just for steel roofs, nails and trashcans,” Eide says. “The global extent of zinc deficiency is debated, but diets that are high in whole grains and low in meat could lead to deficiency.”–If low zinc supply has the same effect on human cells as on yeast, zinc deficiency might contribute to human diseases that are associated with a build-up of “junked” proteins, such as Parkinson’s and Alzheimer’s. Eide says a similar protective system to Tsa1 also exists in animals, and the research group plans to move ahead by studying that system in human cell culture.–Story Source-The above story is based on materials provided by University of Wisconsin-Madison. Note: Materials may be edited for content and length.-Journal Reference-C. W. MacDiarmid, J. Taggart, K. Kerdsomboon, M. Kubisiak, S. Panascharoen, K. Schelble, D. J. Eide. Peroxiredoxin chaperone activity is critical for protein homeostasis in zinc-deficient yeast. Journal of Biological Chemistry, 2013; DOI: 10.1074/jbc.M113.512384
Herbs and Foods with good levels of Accessible Zinc
Burdock Chamomile
Chickweed Dandelion
Echinacea Equisetum
Eyebright Feverfew
Ginger 6.8 Goldenseal
Hawthorn Pau D’Arco
Peppermint Ribwort
Sarsaparilla Stevia
Suma Parsley
Animal Proteins
Chicken 2.5
Beef (steak) 5.5 Lamb (chops) 5.5
Pork 0.5
Nuts and Seeds
Almonds 3.0 Cashew Nuts
Chestnuts 0.5 Hazel Nut 2.4
Macadamia 1.7 Peanuts 3.3
Pecan Nuts 5.0 Pine Nuts 4.3
Pistachio Nuts 1.3 Walnuts 3.0
Almond 3.1
Pumpkin Seeds Sunflower Seeds 5.1
Olive Oil 0.5
Garlic 0.6
Turnip 1.1 Potato 0.9
Carrot 0.5 Cauliflower 0.5
Spinach 0.2 Cabbage 0.2
Cucumber 0.1
[F1]In fast food places all they are doing these days is filtering the fat in the fryer and putting it right back in with some added carcinogenic fat and these burn 15-18 hours a day so all the French fries and fish batter and chicken batter will all accumulate in this fat as well as the acylamide from the potato
[F2]In fast food places 235+ fahr—110 + cel
[F3]Soy and Canola are usually the ones used and canola has high levels of omega 3 which when heated above 104 fahr –becomes a lethal carcinogen
[F4]In other words those fed on plastic had an increase in cholesterol levels—and margarine is made in heat—and they suggest to consume this knowing full well this will cause an increase in health issues
[F5]Anyone want a Chicken fried in fat at a high temp??or fish—or possibly meat?
[F6]And you know every fast food place is going to do these costly test —and when people see what is actually done to the fat in the fryers —you would not ever go back to these places
[F7]This is the case with Morgellon Sufferers—more then one pathology is affecting the immune system in this case a Biopolymer/biofilm which may carry a host of combinations of parasitical and polymers in the system which interact and can be replicating and reproducing at the same time
[F8]Anti-angiogenic therapy is the method of cutting off blood supply to the cancer
[F9]Caspase – any of a group of proteases that mediate apoptosis peptidase, protease, proteinase, proteolytic enzyme – any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis
Show of the Month April 26 2014
Peaches inhibit breast cancer metastasis in mice, study says
Misleading Information on the Properties of Vitamin C
Study reveals new role of vitamin C in skin protection
The prevention of vaccine reactions
Statins = Diabetes Increase
Peaches inhibit breast cancer metastasis in mice, study says
March 25th, 2014 in Cancer /
These are peach trees in research plots at Texas A&M AgriLife Research. Credit: Texas A&M AgriLife Research
Lab tests at Texas A&M AgriLife Research have shown that treatments with peach extract inhibit breast cancer metastasis in mice.
AgriLife Research scientists say that the mixture of phenolic compounds present in the peach extract are responsible for the inhibition of metastasis, according to the study, which was this month published in the Journal of Nutritional Biochemistry.–“Cancer cells were implanted under the skin of mice with an aggressive type of breast cancer cells, the MDA-MB-435, and what we saw was an inhibition of a marker gene in the lungs after a few weeks indicating an inhibition of metastasis when the mice were consuming the peach extract,” said Dr. Luis Cisneros-Zevallos, a food scientist for AgriLife Research in College Station. “Furthermore, after determining the dose necessary to see the effects in mice, it was calculated that for humans it would be equivalent to consuming two to three peaches per day.”–This is very important because it can be translated into something that is also beneficial for people, he added.–This work builds upon previous work at AgriLife Research released a few years ago, which showed that peach and plum polyphenols selectively killed aggressive breast cancer cells and not the normal ones, Cisneros-Zavallos said.–The previous work as well as the present one was conducted by Cisneros-Zevallos, Dr. David Byrne, both with AgriLife Research; Dr. Weston Porter, Texas A&M University department of veterinary physiology and pharmacology; and then-graduate student Giuliana Noratto, who is now on the faculty at Washington State University.–In the western hemisphere, breast cancer is the most common malignant disease for women, he said. In the U.S. last year, the American Cancer Society estimated about 232,340 new cases of invasive breast cancer among women.–Most of the complications and high mortality associated with breast cancer are due to metastasis, Cisneros-Zevallos pointed out.–“The importance of our findings are very relevant, because it shows in vivo the effect that natural compounds, in this case the phenolic compounds in peach, have against breast cancer and metastasis. It gives opportunity to include in the diet an additional tool to prevent and fight this terrible disease that affects so many people,” he said.–The study was conducted using the peach variety Rich Lady. However, according to Cisneros-Zevallos, most peach fruit share similar polyphenolic compounds but might differ in content. The study also determined that the underlying mechanism by which peach polyphenols are inhibiting metastasis would be by targeting and modulating the gene expression of metalloproteinases.[F1]–“In general, peach fruit has chemical compounds that are responsible for killing cancer cells while not affecting normal cells as we reported previously, and now we are seeing that this mixture of compounds can inhibit metastasis,” said Cisneros-Zevallos. “We are enthusiastic about the idea that perhaps by consuming only two to three peaches a day we can obtain similar effects in humans. However, this will have to be the next step in the study for its confirmation.”–Cisneros-Zevallos continues testing these extracts and compounds in different types of cancer as well as in diabetes studies in vitro and in vivo to understand the molecular mechanisms involved.Provided by Texas A&M University—“Peaches inhibit breast cancer metastasis in mice, study says.” March 25th, 2014.
Misleading Information on the Properties of Vitamin C
The Cochrane review by Douglas et al. [1], which is referenced in the Best Practice article by Douglas and Hemilä [2], covers 60 years of research into vitamin C and the common cold. However, the review omits pharmacokinetic data that invalidate the conclusion that vitamin C is ineffective. This conclusion is not derivable from the data presented.
The dual-phase pharmacokinetics of vitamin C are described by the dynamic flow model [3,4]. Low gram-level intakes of ascorbate, leading to blood plasma levels below 70 μM/l, have a half-life of 8–40 days. Higher gram-level intakes have a plasma half-life of 30 minutes [3]. A large oral dose raises blood plasma levels briefly: they reach a peak after two to three hours, before decaying back to baseline. Frequent repeated doses allow sustained high plasma levels of about 250 μM/l [4,5].
Douglas and Hemilä reviewed intakes that transiently raise plasma ascorbate levels above 70 μM/l. A single dose does not raise the median level [6,7]. Daily supplements would, thus, not increase disease resistance to any great degree [3,4]. Single or double doses daily will not increase background plasma levels, regardless of the magnitude of the dose [6,7]. Since plasma ascorbate is at background level for the majority of the day, effects will be minimal.–There is widespread confusion about nutritional and pharmacological levels of supplementation [3]. Linus Pauling, typically, described nutritional gram-level doses able to provide a degree of disease prevention [8]. By contrast, pharmacological doses used for treatment are, at minimum, an order of magnitude larger and involve frequent doses. The doses should be at intervals of three hours or less [3]. Treatment doses are described by Cathcart’s paper on titration to bowel tolerance [9]. To treat the onset of a cold, the therapy is perhaps a minimum of 10 g of oral ascorbic acid, followed by at least 2 g each hour [3,4].–Douglas and Hemilä give a misleading impression by not making it clear that the doses they consider are not pharmacological. They claim that the results of one study, giving an 8-g dose at the start of symptoms, are tantalising and deserve further assessment. However, once this single dose has been excreted, the protective effects will be lost. During illness, ascorbate is depleted rapidly and higher oral intakes are tolerated—up to 200 g per day [9]. It would be surprising if this 8-g dose had a large effect.–Studies on ascorbate require appropriate doses. Douglas and Hemilä have only confirmed that 60 years of vitamin C research has largely been wasted because of confusion between nutritional and pharmacological intakes, and because of a misunderstanding of the pharmacokinetics. It is essential that high-dose studies take into account ascorbate’s dual-phase pharmacokinetics. The dosing regime should allow sustained high plasma levels to be achieved. The claim that vitamin C cannot prevent or cure the common cold is both premature and unwarranted.
1. Douglas RM, Hemilä H, D’Souza R, Chalker EB, Treacy B (2004) Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 4: CD000980. pub2.
2. Douglas RM, Hemilä H (2005) Vitamin C for preventing and treating the common cold. PLoS Med 2: e168. doi: 10.1371/journal.pmed.0020168.
3. Hickey S, Roberts HJ (2004) Ascorbate: The science of vitamin C. Napa (California): Lulu Press. 264 p.
4. Hickey S, Roberts HJ, Cathcart RF (2005) Dynamic flow: A new model for ascorbate. J Orthomol Med. In press.
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5. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, et al. (2004) Vitamin C pharmacokinetics: Implications for oral and intravenous use. Ann Intern Med 140: 533–537.
6. Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, et al. (1996) Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A 93: 3704–3709.
7. Levine M, Wang Y, Padayatty SJ, Morrow J (2001) A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci U S A 98: 9842–9846.
8. Pauling L (1970) Vitamin C and the common cold. New York: W. H. Freeman. 122 p.
9. Cathcart RF (1981) Vitamin C, titrating to bowel tolerance, anascoremia, and acute induced scurvy. Med Hypotheses 7: 1359–1376.
Study reveals new role of vitamin C in skin protection
Published: Wednesday, September 9, 2009 – 08:38 in Health & Medicine
Scientists have uncovered a new role played by Vitamin C in protecting the skin. Researchers at the University of Leicester and Institute for Molecular and Cellular Biology in Portugal studied new protective properties of vitamin C in cells from the human skin, which could lead to better skin regeneration.–The work, by Tiago Duarte, Marcus S. Cooke and G. Don Jones, found that a form of Vitamin C helped to promote wound healing and also helped protect the DNA damage of skin cells. Their findings have been published in the journal Free Radical Biology and Medicine. This report is the latest in a long line of publications from these researchers, at the University of Leicester, concerning vitamin C. Previously, the group has published evidence that DNA repair is upregulated in people consuming vitamin C supplements. The researchers have now provided some mechanistic evidence for this, in cell culture, using techniques such as Affymetrix microarray, for looking at gene expression, and the ‘Comet’ assay to study DNA damage and repair.–Tiago Duarte, formerly of the University of Leicester, and now at the Institute for Molecular and Cellular Biology in Portugal, said: “The exposure to solar ultraviolet radiation increases in summer, often resulting in a higher incidence of skin lesions. Ultraviolet radiation is also a genotoxic agent responsible for skin cancer, through the formation of free radicals and DNA damage. –“Our study analysed the effect of sustained exposure to a vitamin C derivative, ascorbic acid 2-phosphate (AA2P), in human dermal fibroblasts[F2]. We investigated which genes are activated by vitamin C in these cells, which are responsible for skin regeneration. –“The results demonstrated that vitamin C may improve wound healing by stimulating quiescent fibroblasts to divide and by promoting their migration into the wounded area. Vitamin C could also protect the skin by increasing the capacity of fibroblasts to repair potentially mutagenic DNA lesions.”– Dr Marcus S. Cooke from the Department of Cancer Studies and Molecular Medicine and Department of Genetics, at the University of Leicester, added: “The study indicates a mechanism by which vitamin C could contribute to the maintenance of a healthy skin by promoting wound healing and by protecting cellular DNA against damage caused by oxidation”. “These findings are particular importance to our photobiology interests, and we will certainly be looking into this further”.–These results will be of great relevance to the cosmetics industry. Free radicals are associated with premature skin aging, and antioxidants, such as vitamin C, are known to counter these highly damaging compounds. This new evidence suggest that, in addition to ‘mopping up’ free radicals, vitamin C can help remove the DNA damage they form, if they get past the cell’s defences. –The study has the potential to lead to advances in the prevention and treatment of skin lesions specifically, as well as contributing to the fight against cancer.–Source: University of Leicester
The prevention of vaccine reactions
15 November 2004
We know that reports of severe reactions following infant vaccinations, though rare, are causing widespread anxiety among the population. Moreover, physicians are discussing the question as to how many days after vaccination an infant death should be considered as attributable to a vaccine (1). –A review of the World literature on vitamin C and vaccine reactions in animals has revealed that supplementary vitamin C (ascorbic acid) has a potent and highly significant protective effect (2). Ascorbic acid reduces both the morbidity and the mortality following the injection of all bacterial and viral toxins tested in guinea pigs, and even in rats and mice, which make their own ascorbic acid from simple sugars in the liver. Clearly, even the ascorbic acid-producing animals do not always make enough ascorbic acid for all their needs. The highly protective effect of vitamin C has also been reported in children by Kalokerinos (3) in his studies of aborigines in Australia. –One therefore cannot help wondering why the various national centers for disease control have not yet recommended vitamin C to be given before all vaccinations. It would surely be most beneficial, not only in reducing severe vaccine reactions and deaths, but also in reducing or preventing the residual disabilities which can occur following minor cerebral or subdural haemorrhages. –We now know that the bleeding of severe vitamin C deficiency (or scurvy) is due to capillary fragility arising from the accumulation of excessive levels of histamine in the blood (4), causing widening and separation of the tight-junctions between the endothelial cells of the capillaries and venules, from which the bleeding arises (5). The histamine accumulation in scurvy is due to the fact that ascorbic acid is essential for the body’s progressive removal of histamine by converting it to hydantoin-5-acetic-acid and on to aspartic acid in vivo (6). Nowadays, with so many vaccines being given simultaneously to infants, one has to consider that the histamine arising from the injection of these foreign proteins and the histamine arising from any childhood infection will be added to the already elevated blood histamine level due to ascorbic acid depletion, so leading to a toxic blood histamine level which can be fatal. Perhaps this severe condition should not be called Infantile Scurvy or Barlow’s Disease, but rather Toxic Histaminaemia or a Barlow’s Disease Variant. –No doubt Health Departments will soon conduct studies of plasma ascorbic acid and whole blood histamine levels on soldiers before and at various intervals after single and multiple vaccinations for overseas duty. Such studies will certainly confirm that outwardly normal people with somewhat low ascorbate levels have markedly elevated blood histamine levels, and that their blood histamine concentrations increase even more following vaccinations. A more useful estimation of the time range of vulnerability for each vaccine might then be made.
Until then, we can hope
1) That vaccinations will be postponed when an infant is premature or is ailing in any way, even with the common cold.
2) That consideration will be given to reducing the number of vaccines to be given at one time.
3) That 500 mg of vitamin C powder in fruit juice will be given to infants to drink before their vaccinations. (More vitamin C can be given by intramuscular injection, if the infant develops a high-pitched cry, a febrile illness, or has a convulsion.)
C.A.B. Clemetson, M.D., Professor Emeritus, Tulane University School of Medicine, New Orleans, Louisiana, Tele: 504-866-1525, Email: [email protected]
1) Buttram H. Shaken baby syndrome, or vaccine-induced encephalitis? Med Sentinel 2001; 6:83-89.
2) Clemetson CAB. Vaccinations, inoculations, and ascorbic acid. J Orthomolecular Med 1999; 14:137-142.
3) Kalokerinos A. Medical Pioneer of the 20th Century. Melbourne, Victoria, Australia: Biological Therapies Publishing Pty Ltd; 2000.
4) Clemetson CAB. Histamine and ascorbic acid in human blood. J Nutr 1980; 110:662-668.
5) Clemetson CAB. Is it “shaken baby,” or Barlow’s disease variant? J Amer Phys Surg 2004; 9:78-80.
6) Chatterjee IB, Majumder AK, Nandi BK, Subramanian N. Synthesis and some major functions of vitamin C in animals. Ann NY Acad Sci 1975; 258:24 -47.
Statins = Diabetes Increase
Because while more and more studies are showing us just how dangerous statins are, the vultures are circling more than ever. –Big Pharma’s latest plans for selling statins is very targeted — with just about every single person is in the crosshairs.-You know that old high cholesterol myth — the one that’s been drummed into us for years. Well, it didn’t seem to be selling enough statins to satisfy the profit-hungry drug makers. So their buddies at the American Heart Association and the American College of Cardiology put a “calculator” together to fix that problem.–That did away with the spin-the-wheel game of ‘cholesterol target numbers’ and replaced it with a simple seven-question quiz. –The numbers — just published in the New England Journal of Medicine — show that practically all men over 60 and just about 50 percent of everyone else over 40 meet the new standards for a regular dose of Lipitor.–This is the first “independent” look at the impact of these new guidelines. –And it boils down to this — an immediate increase of over 13 million who will now “need” statins. –When the AHA and ACC “calculator” was first unveiled last year, experts from Harvard said it had “serious flaws” that could overestimate a person’s risk of heart disease by up to 150 percent. And they warned the heart groups about that over a year before this deadly ‘recalculation’ was released, saying it just didn’t work. –And the Harvard folks weren’t the only ones asking them to put the brakes on it. The top heart doc at the Cleveland Clinic also said it needed further evaluation before being “implemented on a widespread basis.”—And that’s probably because when statin sales go up, cases of diabetes go up with them. –In fact, a new study found that among statin users, one in every five new cases of diabetes was linked to the drug.— one in five! And women appear to be much more prone to this diabetes risk than men. If they did a study using only women, The numbers may reflect a different stat..But that’s not the only known side effect. Others include impotence, cataracts, muscle pains, mental impairment, fatigue, and liver dysfunction. -But over in the U.K. they’ve been sounding the alarm — The deputy chairman of the British Medical Association has said that plans to increase statin use would “only benefit drug companies.” Others said they will urge their government to “reconsider its move” before it puts millions more Brits at risk. –One even likened it to keeping “people from dying from heart disease by pushing them off a cliff.”
“‘Eye-opening’ new report about statin eligibility” AP, March 19, 2014,
“Health chief slams statins: millions face terrible side effects as prescription escalates” Lucy Johnston, March 2, 2014, Express,
“Some doctors challenge new statin guidelines” Dennis Thompson, November 18, 2013, Health Day,
– See more at:
[F1]Metalloproteinases-are metals that prduce a estrogenic effect and can over load the receptor sites where estrogen bind and mutate to something they should not
[F2]Ascorbic Acid and Phosphorus

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